英文：Association between depression and enterovirus infection: A nationwide population-based cohort study
作者：精神科 廖尹鐸 主治醫師
|本篇論文發表於 Medicine (Baltimore) 期刊 2017 Feb;96(5):e5983. doi: 10.1097 全文下載
explores association between EV infection and subsequent depression in children and adolescents and assesses the risk of depression after EV infection with central nervous system involvement in a nationwide population-based retrospective cohort.
Children and adolescents with EV infection had no elevated risk of depression compared to healthy controls (adjusted hazard ratio, aHR = 1.00, 95% CI: 0.83-1.21). However, CNS EV infection was associated with increased risk of depression (aHR = 1.62, 95% CI: 1.02-2.58) in the fully adjusted Cox regression model.
We found CNS EV infection was associated with increased risk of depression in children and adolescents in a nationwide population-based cohort study. Future biological research may provide the mechanism or pathophysiology of depression associated with EV infection. In clinical practice, we suggest that children with CNS EV infection should receive proper psychological assessment and monitoring for emerging depression with the rationale of these children being a susceptible group for depressive disorder.