Association between depression and enterovirus infection: A nationwide population-based cohort study

研究焦點

論文名稱

英文:Association between depression and enterovirus infection: A nationwide population-based cohort study

作者:精神科 廖尹鐸 主治醫師

本篇論文發表於 Medicine (Baltimore) 期刊  2017 Feb;96(5):e5983. doi: 10.1097 全文下載

研究目的:

以全人口資料去探討EV感染以及之後發生憂鬱的風險,特別探討有CNS影響之EV感染。

explores association between EV infection and subsequent depression in children and adolescents and assesses the risk of depression after EV infection with central nervous system involvement in a nationwide population-based retrospective cohort.

研究結果:

有EV感染的小孩及青少年並沒有增加入日後得到憂鬱症的風險,調整後風險比為1.00。然而有CNS影響之EV感染則顯著增加憂鬱/風險,危險機率為1.62,調整過其他干擾因子後仍然達到統計顯著。

Children and adolescents with EV infection had no elevated risk of depression compared to healthy controls (adjusted hazard ratio, aHR = 1.00, 95% CI: 0.83-1.21). However, CNS EV infection was associated with increased risk of depression (aHR = 1.62, 95% CI: 1.02-2.58) in the fully adjusted Cox regression model.

研究貢獻與臨床應用:

我們的研究發現有CNS影響的EV感染會增加孩童日後得到憂鬱症的機率,病生理機轉及共同的生理致病機轉仍有待研究。臨床層面,嚴重的EV感染可能需要檢視憂鬱的症狀,避免併發症。

We found CNS EV infection was associated with increased risk of depression in children and adolescents in a nationwide population-based cohort study. Future biological research may provide the mechanism or pathophysiology of depression associated with EV infection. In clinical practice, we suggest that children with CNS EV infection should receive proper psychological assessment and monitoring for emerging depression with the rationale of these children being a susceptible group for depressive disorder.