論文名稱
英文：Risk of bipolar disorder in patients with COPD: a population-based cohort study
作者：精神科 廖尹鐸 主治醫師
| 本篇論文發表於 Gen Hosp Psychiatry 期刊 2016 Jul-Aug;41:6-12. doi: 10.1016/j.genhosppsych.2016.04.004 全文下載 |
研究目的：
很少研究調查COPD和雙極性情感疾患之間的關連性，此研究以一個全國性採樣的大樣本來探查兩者之間的關聯性。
Few studies have investigated the relationship between Chronic Obstructive Pulmonary Disease (COPD) and bipolar outcomes in the world. We sought to investigate the association between COPD and risk of bipolar disorder in a large national sample.
研究結果：
71116個個案中，202個個案在追蹤期間有新診斷之雙極性情感疾患。平均追蹤時間為6年。COPD、較年輕、低社經地位、較少的類固醇使用，較多的住院天數及較多的門診追蹤與雙極性情感疾患有相關性。
Of the total 71,116 subjects, 202 were newly diagnosed with bipolar disorder during the study period. The mean follow-up time was 6.0 (SD=2.2) years. COPD, younger age, lower economic status, lower dose of prednisone use, higher hospital admission days and higher outpatient visits were independent predictors of bipolar disorder.
COPD was associated with increased risk of bipolar disorder independent of a number of potential confounding factors in this study.
研究貢獻與臨床應用：
應用全國性健保資料庫，我們發現COPD與雙極性情感疾患有關聯，臨床上可能需要注意共病的現象，情緒的變化可能在治療中需要被注意，更進一步的病生理相關性需要於前瞻性研究來探討。
Our findings from a national health insurance dataset are consistent with a link between COPD and bipolar disorder. Given the high and potentially rising prevalence of COPD, clinicians may need to consider the risk of bipolar disorder in particular. Identifying change in mood status and the past history of bipolar disorder in high risk groups such as younger age, lower economic status, lower dose of prednisone use, longer hospitalization and higher outpatient visits for timely specialist referral or intervention are important. Further research is needed to explore the underlying mechanisms and pathophysiological linkage between COPD and bipolar disorder.
