英文：Risk of bipolar disorder in patients with COPD: a population-based cohort study
作者：精神科 廖尹鐸 主治醫師
|本篇論文發表於 Gen Hosp Psychiatry 期刊 2016 Jul-Aug;41:6-12. doi: 10.1016/j.genhosppsych.2016.04.004 全文下載|
Few studies have investigated the relationship between Chronic Obstructive Pulmonary Disease (COPD) and bipolar outcomes in the world. We sought to investigate the association between COPD and risk of bipolar disorder in a large national sample.
Of the total 71,116 subjects, 202 were newly diagnosed with bipolar disorder during the study period. The mean follow-up time was 6.0 (SD=2.2) years. COPD, younger age, lower economic status, lower dose of prednisone use, higher hospital admission days and higher outpatient visits were independent predictors of bipolar disorder.
COPD was associated with increased risk of bipolar disorder independent of a number of potential confounding factors in this study.
Our findings from a national health insurance dataset are consistent with a link between COPD and bipolar disorder. Given the high and potentially rising prevalence of COPD, clinicians may need to consider the risk of bipolar disorder in particular. Identifying change in mood status and the past history of bipolar disorder in high risk groups such as younger age, lower economic status, lower dose of prednisone use, longer hospitalization and higher outpatient visits for timely specialist referral or intervention are important. Further research is needed to explore the underlying mechanisms and pathophysiological linkage between COPD and bipolar disorder.