Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1α-Sirt1 Pathway

1.研究結果：

內容為原著研究, 探討NaIO3引起大鼠視網膜損傷,經由氧化及自噬作用下,再投與Quercetin後看其氧化壓力與自噬作用下的變化,我們的研究發現indicated that the effects of quercetin on regulating the generation of mtROS were dependent on increased levels of deacetyl-SOD2 through the
Nrf2-PGC-1α-Sirt1 signaling pathway. These results demonstrated that quercetin may have potential therapeutic efficacy for the treatment of AMD through the regulation of mtROS homeostasis.

2.研究貢獻與臨床應用：

粒線體自嗜作用對於視網膜氧化壓力影響很多,若有抗氧化物能減緩其氧化壓力,對於疾病預防及治療可能有其幫助