論文名稱
英文：Low-Dose Aspirin Reduces Breast Cancer Risk in Women with Diabetes: A Nationwide Retrospective Cohort Study in Taiwan.
作者：內科 楊宜瑱
| 本篇論文發表於 Journal of Womens Health 期刊 2017 May 24 online全文下載 |
研究目的：
本基礎研究發現高糖誘導下易導致乳癌細胞增生及轉移，進而利用藥物試圖抑制作用 目前結果還再研究中，嫌利用大型數據的資料探討藥物研究，以利選擇細胞研究的藥物抑制
Our findings suggest that a cumulative aspirin dosage of more than 88,900 mg daily was associated with a reduced risk of breast cancer in women with diabetes. However, additional studies are necessary to confirm these findings.
研究結果：
RESULTS:
We analyzed 148,739 patients with diabetes. Their mean age (standard deviation) was 63.3 (12.8) years. A total of 27,378 patients were taking aspirin. Overall, the use of aspirin in patients with diabetes reduced the risk of breast cancer by 18% (hazard ratio [HR], 0.82; 95% confidence interval [CI], 0.71-0.94) after adjustment for potential confounders, namely age and comorbidities. Specifically, a cumulative dose of aspirinexceeding 88,900 mg was observed to reduce the risk of breast cancer by 47% (HR, 0.53, 95% CI, 0.43-0.67); however, low (<8,600 mg) and medium (8,600-88,900 mg) cumulative doses of aspirin did not reduce the risk ofbreast cancer.
研究貢獻與臨床應用：
CONCLUSIONS:
Our findings suggest that a cumulative aspirin dosage of more than 88,900 mg daily was associated with a reduced risk of breast cancer in women with diabetes. However, additional studies are necessary to confirm these findings.
