【公告】本院小兒血液腫瘤科新進醫師－巫康熙醫師

最新公告
Chung Shan Medical University Hospital

巫康熙醫師 (於4月份於本院服務)1090309

 

現任

  1. 中山醫學大學附設醫院 副院長
  2. 中山醫學大學醫學系 教授
  3. 台灣血液及骨髓移植學會 指導醫師
  4. 中華民國血液病學會 指導醫師
  5. 台灣兒科醫學會 兒童血液腫瘤學 委員
  6. 中華民國兒童癌症基金會 學術小組委員會 委員
  7. 中華民國兒童癌症基金會 台灣兒童癌症研究群 顧問醫師
  8. 台灣血液及骨髓移植學會 專科醫師甄審委員會/編輯委員會 委員
  9. 臺灣中西整合醫學會 理事
  10. 台灣海洋性貧血協會 顧問醫師
  11. 台灣兒科醫學會 學術節目委員會 委員
  12. 台灣兒科醫學會 兒科最前線雜誌 執行主編

專長

  1. 兒童惡性及良性腫瘤 (包括不明腫塊/腫瘤、血管瘤)
  2. 血液疾病 (包括貧血、紫斑症、白血球過高/過低)
  3. 小兒疾病 (包括不明原因發燒)
  4. 骨髓移植 (包括臍帶血移植、周邊造血幹細胞移植骨髓移植)
  5. 幹細胞轉譯醫學

專科醫師

  1. 台灣兒科醫學會兒科專科醫師
  2. 中華民國血液及骨髓移植專科醫師
  3. 中華民國血液病專科醫師

學歷

中國醫藥大學 醫學士

教職

教育部審定合格教授(教字第141601號；2014年8月迄今)
教育部審定合格副教授(副字第040201號；2010年8月-2014年7月)
教育部審定合格助理教授(助理字第020163號；2007年1月-2010年7月)
教育部審定合格講師(講字第077537號；2004年1月-2006年12月)

榮譽(Honor)

  1. 2008年商業周刊百大良醫推薦好醫師
  2. 2012 & 2018年中國醫藥大學附設醫院傑出醫師
  3. 2003 & 2004年中國醫藥大學附設醫院優良醫師
  4. 韓國、越南、亞美尼亞等多國醫師台向巫醫師學習
  5. 2008~2012年國際會議Pan Pacific Symposium on Stem Cells and Cancer Research組織委員會委員
  6. 多次國際大會應邀演講及主持人
  7. 為國際知名SCI醫學期刊論文審稿學者(reviewer)
  8. 發表上百篇論文於國際知名SCI醫學期刊
  9. 12th International Conference on Oral Chelation in the Treatment of Thalassaemia and Other Diseases (2002) 優良論文發表獎
  10. 台灣血液病學會2006年青年優秀論文獎
  11. 2019年中華民國私立教育事業會 資深暨優良教師獎
  12. 指導多位碩士和博士畢業，並擔任多位碩士和博士口試委員
  13. 科技部(國科會) 2014、2015、2018、2019年複審會委員

經歷

  1. 中山醫學大學附設醫院 兒童血液腫瘤科主任
  2. 台大醫院兒科部 小兒血液腫瘤科研究醫師
  3. 中國醫藥大學兒童醫院 兒童血液腫瘤科主任
  4. 中國醫藥大學兒童醫院 兒童腫瘤委員會 主任委員
  5. 中國醫藥大學附設醫院 檢驗醫學部血庫主任
  6. 中國醫藥大學兒童醫院 血液腫瘤病房 病房主任
  7. 中國醫藥大學附設醫院 組織庫暨血液幹細胞研究室顧問醫師
  8. 中國醫藥大學附設醫院 移植委員會/輸血委員會/組織庫委員會/病房管理委員會/安寧療護委員會 委員
  9. 中國醫藥大學 學士後中醫學系 系主任
  10. 中華民國關懷腦瘤兒童協會 顧問醫師
  11. 中華民國喜願協會 顧問醫師
  12. 台灣兒科醫學會 專科醫師甄選委員會 委員

醫學重要成就

(一)兒童癌症: 對各種兒童癌症有先進的治療和深入的研究
1. 曾刊於世界頂尖期刊Journal of Clinical Oncology (發表於2002impact factor: 32.956)
2. 發現麩醯胺酸(Glutamine)可顯著降低白血病病童，在使用高劑量化療藥MTX，所造成的嚴重口腔潰瘍
3. 多篇血癌相關研究，用第二代標靶藥，成功治痊費城染色體急性淋巴性白血病骨髓移植後復發 (發表於Pediatr Blood Cancer 2013)
4. 發現世界第一位陰莖淋巴癌病童，也成功治療，沒有後遺症 (發表於J Pediatr Hematol Oncol 2006)
5. 和多家醫學中心合作，發現許多血癌的相關基因，對精準醫療很有助益
6. 對個種兒童癌症，血癌、淋巴癌、，神經母細胞癌、生殖細胞癌、骨癌、蘭格罕氏組織細胞增多症、威爾姆氏瘤….等都有SCI國際期刊發表

(二)骨髓移植: 不但有高的成功率，發表多篇造血幹細胞移植相關研究
1. 如何加速臍帶血移植造血功能的恢復 (發表於Transplantation 2013)
2. 自體臍帶血移植(發表於Bone Marrow Transplant 2013)
3. 移植後排斥的治療 (發表於Transplantation 2011; Medicine 2017)
4. 移植後BK病毒引起出血性膀胱炎的治療 (發表於Pediatr Infect Dis J 2014)，且被知名感染科教科書”熱病”引用
5. 黴菌感染的處理 (發表於PediatrTransplant 2012; Ital J Pediatr 2016
6. 國際醫療，成功骨髓移植救治蘇丹和印尼病童

(三)血液疾病 (海洋性貧血、再生不良性貧血、血小板低下紫斑症、輸血醫學)
1. 海洋性貧血: 發表數十篇海洋性貧血相關研究，不但臨床幫助台灣病患，也幫助相同疾病的國際病人。合併使用排鐵劑，成功救治重度海洋性貧血病患的嚴重心臟併發症，不但幫助這死亡率極高的問題，也獲世界很大回響 (發表於Ann Hematol 2004; Ann Hematol 2020)
2. 再生不良性貧血: 從基礎到治療，發表多篇再生不良性貧血的深入研究。並深入研究間質幹細胞在再生不良性貧血的角色，不但是這方面的pioneer，也獲世界肯定 (發表於AnnHematol 2010; Pediatr Blood Cancer 2018)
3. 血小板低下紫斑症: 發現兒童免疫血小板低下紫斑症和基因有關，發表於世界知名的期刊 (發表於Br J Haematol 2005)
4. 輸血醫學: 發現台灣特有的紅血球抗體，anti-Mia會造成嚴重新生兒黃疸 (世界第二例，發表於TransfusMed 2002)

(四) 幹細胞: 為間質幹細胞研究的pioneer
1. 世界第一位將臍帶間質幹細胞應用到人體上，證明其安全有效 (發表於Transplantation2011)
2. 從基礎到動物，應用到人體，發表數十篇間質幹細胞相關研究，不但對間質幹細胞研究十分深入，也為將來轉譯醫學的應用，立下很好的基礎。
3. 發現黃耆萃取物(PG2)可加速間質幹細胞的生長，並加強免疫抑制效果 (發表於J Ethnopharmacol 2017)

(五) 小兒科學: 和小兒科醫生合作，發表許多兒科相關的研究，如感染，免疫力低下，急重症..等

醫學著作

  1. 海洋性貧血是什麼？(出版社: 合記書局有限公司)
  2. 關於地中海型貧血 (出版社: 藝軒圖書出版社)

兒童血液腫瘤疾病專業網頁

提供最專業、正確、親民、完整且充實的兒童癌症和血液疾病資訊，至今(2020年9月，已有593,165觀看人次)
http://www.onped.com/hema/index.php

兒童血液腫瘤疾病相關YouTube

  1. 兒童癌症介紹首部曲 (中山醫學大學附設醫院)
  2. 兒童貧血和血小板低下介紹 (中山醫學大學附設醫院)
  3. 兒童血管瘤和骨髓移植介紹 (中山醫學大學附設醫院)
  4. 全民健康保健378 (唯心電視台)
  5. 全民健康保健379 (唯心電視台)
  6. 全民健康保健380 (唯心電視台)

相關媒體報導: (2007-2020)

  1. 中山附醫成立血液病中心 患者以歌聲和吉他演奏祝賀 (2020)
  2. 兒童安寧！哈韓少女印手模留父母含笑離世 (2020)
  3. 印傭幼女罹血癌台灣老闆這麼做暖哭眾人 (2020)
  4. 海洋性貧血長期輸血鐵質易過量累積 醫學突破免侵入偵測心臟、肝臟鐵質沈積量 (2020)
  5. 幫五月大嬰兒洗澡摸到腫塊 竟是肝母細胞癌 (2016)
  6. 國三女戰勝惡性淋巴癌 榮獲總統教育獎 (2016)
  7. 抗血癌小鬥士變白衣天使 她立志守護癌童 (2015)
  8. 「光頭甭吹髮」童樂觀抗癌 (2014)
  9. 賣餅罕見血液病童出院 好想上學 (2014)
  10. 捐幹細胞救人　新捐髓技術無後遺症 (2013)
  11. 全球首例 臍帶間質幹細胞-救血液病患 移植7天就能造血 (2011)
  12. 921災民救血癌女 難扛醫費 (2010)
  13. 該為寶寶存臍帶血嗎？ (2008)
  14. 來台換骨髓 蘇丹男童開心返家 (2008)
  15. 慈母捐隨救重病愛女 配對僅6成吻合 國內首例成功 (2005)
  16. 臍帶間質幹細胞 人體試驗成功
  17. 全國首例 罹惡性神經母細胞癌靠臍帶血自救
  18. 非親屬臍帶血移植 重度海洋性貧血童獲重生 (2007)
  19. 全台首例 自存臍帶血 義捐救命 (2007)
  20. 抗癌少女 病史編成舞 (2007)
  21. 臍帶血配對 機率高於骨髓 (2007)
  22. 醫師：臍帶血量不足 治療瓶頸 (2007)
  23. 母吃泡麵省錢籌血癌兒醫費 (2007)

國際會議邀請演講(invited speaker)

  1. Thalassemia and Aplastic Anemia: From Past to Present (Cross-Strait Hematology Conference, 2017)
  2. Clinical application mesenchymal stem cells derived from umbilical cord in hematopoietic stem cell transplantation. (Perinatal Stem Cell Society Conference, USA, 2016)
  3. Clinical application of mesenchymal stem cells derived from umbilical cord in hematopoietic stem cell transplantion (AsiaCORD Conference, Japan, 2013)
  4. Mesenchymal stem cells in hematopoietic stem cell transplantation (Japan-Korea-Taiwan Symposium on Maternal-Fetal Medicine, 2012)
  5. Comparisons of suppressive effects between human fetal-type mesenchymal stem cells (MSCs) and bone marrow-derived MSCs (Cross-Strait Hematology Conference, 2011)
  6. Cotransplantation of hematopoietic stem cells and mesenchymal stem cells (Pan Pacific Symposium on Stem Cells and Cancer Research, 2008)

研究計劃

(1).科技部計劃：
主持人:
1. 從臍帶血及臍帶間質幹細胞共同培養大量人類血紅素(2007-2008)
2. 人類不同來源間質幹細胞在移植抗宿主疾病的比較和機轉研究 (2011-2012)
3.兒童重度再生不良性貧血病患骨髓間質幹細胞免疫調整功能和基因表現的研究(2013-1016)
4.胚胎到成體不同階段之細胞上清液免疫調整功能的比較與機轉研究(2017-2018)
5.研究人類各種胎兒組織外泌體的免疫調整功能及其機轉(2018-2021)
協同主持人:
1. 三階段支持性護理對接受幹細胞移植病童照顧者之困擾及生活品質成效：跨機構縱貫性研究(2016)
2. 比較來自不同胎兒組織之培養清液與間質幹細胞對於敗血症動物的免疫調節潛力與機轉 (2016-2017)
3. 分析兒童嚴重再生不良性貧血之骨髓間質幹細胞及其培養清液 (2018-2019)
4. 評估兒童嚴重再生不良性貧血之間質幹細胞的改變及黃耆對幹細胞的影響 (2019-2021)

(2).國衛院計劃主持人
104年兒科重難症醫療照護團隊獎勵方案計畫(兒童癌症)
105年兒科重難症醫療照護團隊獎勵方案計畫(兒童癌症)

(3).衛生福利部
整合台灣兒童癌症臨床治療及分子診斷: 兒童急性白血病之醫療經濟學分析(2018-2022)

(4).産學合作計劃主持人
1. 訊聯生物科技股份有限公司: 臍帶血和臍帶間質幹細胞共同移植(2007-2009) (獲經濟部工業局千萬經費補助)
2. 大展生命科技股份有限公司: 缺血及缺氧性高危險妊之娠臍帶血主動留存相關醫療輔助研究 (2009/01/01-2009-12/31)
3. 輝瑞大藥廠股份有限公司: 一個前瞻性、開放性標示之研究：評估anidulafungin於 治療侵入性念珠菌感染(包括念珠菌血症)之兒童之藥物動力學、安全性及療效 (2011-2013)
4. 生寶生物科技股份有限公司: 臍帶間質幹細胞治療敗血症動物的實驗和機轉分析 (2012-2013)
5. 台灣尖端先進生技醫藥股份有限公司: TAT-HOXB4蛋白對臍帶血增生後移植效果 (2013-2016)

(5).醫學中心研究計劃
主持人:
1. 福善美錠(fosamaxtablets)在乙型重度海洋性貧血病患骨質疏鬆的治療(2005)
2. 由週邊造血幹細胞在體外培養成人類紅血球(2007)
3. 從人類胚胎幹細胞和臍帶間質幹細胞共同培養人類造血幹細胞(2007)
4. 骨髓和臍帶間質幹細胞在不同代數對T淋巴細胞抑制作用的比較(2009)
5. 人類不同來源間質幹細胞在移植抗宿主疾病和免疫調整功能在體內的比較及機轉研究(2010)
6. 隨機-雙盲試驗-評估靜脈左旋麩醯胺酸（L-Glutamine）對診斷為急性淋巴性白血病（ALL）之兒童病患接受化療藥物（MTX）後引起之口腔黏膜炎、營養及生活品質的改善情形(2011)
7. 以人類臍帶間質幹細胞上清液治療敗血症老鼠(2013)
8. 以時間序列探討和比較Toll-like受體在骨髓和臍帶間質幹細胞治療敗血症動物時的機轉(2014)
9. 黃耆對臍帶間質幹細胞的影響及其機轉的探討(2015)
10.以時間序列探討Toll-like受體在人類絨毛細胞上清液治療敗血症動物時的機轉(2017)
11. 探討兒童嚴重再生不良性貧血幹細胞之缺陷(2019)

國際SCI雜誌發表(2002-2020，按年代順序):

  1. Wu KH, Chang JG, Lin M, Shih MC, Lin HC, Lee CC, Peng CT, Tsai CH. Hydrops foetalis caused by anti-mur in first pregnancy–a case report. Transfus Med. 2002;12:325-7.
  2. Wu KH, Chu SL, Chang JG, Shih MC, Peng CT. Haemolytic disease of the newborn due to maternal irregular antibodies in Chinese population in Taiwan. Transfus Med. 2003;13:311-4.
  3. Wu KH, Tsai FJ, Peng CT. Growth hormone (GH) deficiency in patients with b-thalassemia major and the efficacy of recombinant GH treatment. Ann Hematol. 2003;82:637-40.
  4. Wu KH, Chang JS, Tsai CH, Peng CT. Combined therapy with deferiprone and desferrioxamine successfully regresses severe heart failure in patients with beta-thalassemia major. Ann Hematol. 2004;83:471-3. (Times Cited: 57 from Web of Science in 2020)
  5. Wu KH, Chang JS, Su BH, Peng CT. Tricuspid regurgitation in patients with beta-thalassemia major. Ann Hematol. 2004; 83:779-83. 
  6. Shih MC, Wu KH, Liu SC, Chang JG. Hb Tak: a beta chain elongation at the end of the beta chain, in a Taiwanese. Hemoglobin. 2005; 29:65-7.  
  7. Wu KH, Peng CT, Li TC, Wan L, Tsai CH, Lan SJ, Chang MC, Tsai FJ . Interleukin 4, interleukin 6 and interleukin 10 polymorphisms in children with acute and chronic immune thrombocytopenic purpura. Br J Haematol. 2005; 128:849-52. 
  8. Peng CT, Wu KH, Lan SJ, Tsai JJ, Tsai FJ, Tsai CH. Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy. Eur J Cancer. 2005; 41:1158-63.
  9. Peng CT, Wu KH*, Wu SF, Liang DC, Yang CP, Jang RC, Wang LY, Hsiao CC. Deferiprone or deferoxamine vs. combination therapy in patients with beta-thalassemia major: a case study in Taiwan. Hemoglobin. 2006;30:125-30. (*corresponding author)
  10. Kuo HT, Tsai MY, Peng CT, Wu KH. Pilot Study on “Quality of Life” as reflected by psychosocial adjustment of children with thalassemia major undergoing iron-chelating treatment in west Taiwan. Hemoglobin.2006;30:291-9.
  11. Wang CH, Wu KH, Tsai FJ, Peng CT. Comparison of oral and subcutaneous iron chelation therapy in prevention of major endocrinopathies in b-thalassemia major patients. Hemoglobin.2006;30:257-62.
  12. Wu KH, Chang JG, Ho YJ, Wu SF, Peng CT. Glutathione S-transferase M1 gene polymorphisms are associated with cardiac iron deposition in patients with b-thalassemia major.Hemoglobin.2006;30:251-6.
  13. Huang YC, Chang JS, Wu KH, Peng CT. Regression of myocardial dysfunction after switching from deferoxamine to deferiprone in b-thalassemia major patients. Hemoglobin. 2006; 30:229-38.
  14. Wu SF, Peng CT, Wu KH, Tsai CH.Liver fibrosis and iron levels during long-term treatment of thalassemia major patients with deferiprone. Hemoglobin. 2006; 30:215-8.
  15. Chen AC, Peng CT, Wu SF, Wu KH, Chiang IP, C-H Tsai CH.Effect of deferiprone on liver iron overload and fibrosis in hepatitis C virus infected thalassemia. Hemoglobin. 2006; 30:209-14.
  16. Wei CC, Peng CT, Chiang IP, Wu KH*. Primary B cell non-Hodgkin’s lymphoma of the penis in a child. J Pediatr Hematol Oncol. 2006; 28:479-80. (*corresponding author)
  17. Wu KH, Peng CT, Li TC, Wan L, Tsai CH, Tsai FJ. Interleukin 1β Exon 5 and interleukin 1 receptor antagonist in children with acute and chronic immune thrombocytopenic purpura. J Pediatr Hematol Oncol. 2007; 29:305-8.
  18. Peng CT, Tsai CH, Wu KH. Effects of chelation therapy on cardiac function improvement in thalassemia patients: literature review and the Taiwanese experience. Hemoglobin. 2008;32:49-62.
  19. Wu SF, Chen AC, Peng CT, Wu KH*. Octreotide therapy in asparaginase-associated pancreatitis in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2008;51:824-5. (*corresponding author)
  20. Peng CT, Chang JS, Wu KH, Tsai CH, Lin SH. Mechanisms of and obstacles to iron cardiomyopathy in thalassemia. Front Biosci. 2008; 13:5975-87.
  21. Lin CH, Wu KH, Lin WC, Tsai JD, Peng CT, Chen AC. Granulocytic sarcoma of the colon in a child with acute myeloid leukemia presenting as hematochezia. J Pediatr Hematol Oncol. 2008; 30:981-3.
  22. Chang YH, Shaw CF, Wu KH, Hsieh KH, Su YN, Lu PJ. Treatment with deferiprone for iron overload alleviates bone marrow failure in a Fanconi anemia patient. Hemoglobin. 2009; 33: 346-51.
  23. Peng CT, Chang JS, Wang LY, Chiou SS, Hsiao CC, Wang SC, Hung GY, Wu KH*. Update on thalassemia treatment in Taiwan, including bone marrow transplantation, chelation therapy, and cardiomyopathy treatment effects. Hemoglobin. 2009; 33:304-11. (*corresponding author)
  24. Wu KH, Wang CH, Yang YL, Peng, CT, Lin WD, Tsai FJ, Lin DT, Bau DT. Significant association of XRCC4 single nucleotide polymorphisms with child leukemia in Taiwan. Anticancer Res. 2010; 30:529-34.
  25. Liang DC, Yang CP, Lin DT, Hung IJ, Lin KH, Chen JS, Hsiao CC, Chang TT, Peng CT, Lin MT, Chang TK, Jaing TH, Liu HC, Wang LY, Yeh TC, Jou ST, Lu MY, Cheng CN, Sheen JM, Chiou SS, Wu KH, Hung GY, Chen RL, Chen SH, Cheng SN, Chang YH, Chen BW, Ho WL, Wang JL, Lin ST, Hsieh YL, Wang SC, Chang HH, Yang YL, Huang FL, Chang CY, Chang WH, Lin KS. Long-term results of Taiwan pediatric oncology group studies 1997 and 2002 for childhood acute lymphoblastic leukemia. Leukemia. 2010;24:397-405.
  26. Lin CH, Lin WC, Chiang IP, Ho YJ, Peng CT, Wu KH*. Langerhans cell histiocytosis with thyroid and lung involvement in a child: a case report. J Pediatr Hematol Oncol. 2010;32:309-11. (*corresponding author)
  27. Lin CH, Lin WC, Wang CH, Ho YJ, Chiang IP , Peng CT, Wu KH*. Child with ataxia telangiectasia developing acute myeloid leukemia. J Clin Oncol. 2010; 28:213-4. (SCI: 32.956 in 2020) (*corresponding author)
  28. Lee WI, Huang JL, Jaing TH, Wu KH, Chien YH, Chang KW. Clinical aspects and genetic analysis of Taiwanese patients with Wiskott-Aldrich syndrome protein mutation: the first identification of x-linked thrombocytopenia in the Chinese with novel mutations. J Clin Immunol. 2010; 30:593-601.
  29. Chao YH, Peng CT, Harn HJ, Chan CK, Wu KH*. Poor potential of proliferation and differentiation in bone marrow mesenchymal stem cells derived from children with severe aplastic anemia. Ann Hematol. 2010; 89:715-23. (*corresponding author)
  30. Wang CH, Wu KH*, Yang YL, Peng CT, Wang RF, Tsai CW, Tsai RY, Lin DT, Tsai FJ, Bau DT. Association study of cyclooxygenase 2 single nucleotide polymorphisms and childhood acute lymphoblastic leukemia in Taiwan. Anticancer Res. 2010; 30:3649-3653. (*equal contribution author)
  31. Yang YL, Lin SR, Chen JS, Hsiao CC, Lin KH, Sheen JM, Cheng CN, Wu KH, Lin SW, Yu SL, Chen HY, Lu MY, Chang HH, Yen CT, Lin JF, Su YH, Li YP, Lin CY, Jou ST, Lin DT. Multiplex reverse transcription-polymerase chain reaction as diagnostic molecular screening of 4 common fusion chimeric genes in Taiwanese children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2010; 32:323-30.   
  32. Chao YH, Tsai C, Peng CT, Wu HP, Chan CK, Weng TF, Wu KH*. Cotransplantation of umbilical cord mesenchymal stem cells to enhance engraftment of hematopoietic stem cells in patients with severe aplastic anemia. Bone Marrow Transplant. 2010; 46:1391-2 (*corresponding author)
  33. Su BH, Wu KH＃, Lin HY, Lin MH, Peng CT, Tsai C. Umbilical cord-derived mesenchymal stem cells for severe bronchpulmonary dysplasia. Pediatrics. 2011; 26:1127-33. (＃equally author)
  34. Wu KH, Chan CK, Tsai C, Chang YH, Sieber Martin, Chiu TH, Ho M, Peng CT, Wu HP, Huang JL. Effective treatment of severe steroid-resistant acute graft-versus-host disease with umbilical cord-derived mesenchymal stem cells. Transplantation. 2011; 91:1412-6. (Times Cited: 78 from Web of Science in 2020 )
  35. Yang WC, Chen JY, Wu KH, Wu HP. Acute onset of dizziness caused by a cavernous malformation lateral to the fourth ventricle: a case report. Pediatr Neonatol. 2011; 52:113-6.
  36. Chao YH, Wu HP, Chiang IP, Peng CT, Yang YL, Wu KH*. Rhabdomyomatous differentiation in primary Wilms tumor and hepatic metastases after chemotherapy and all-trans-retinoic acid in combination with interferon-α. Pediatr Blood Cancer. 2011; 57:698-9. (*corresponding author)
  37. Yang YL, Hung CC, Chen JS, Lin KH, Jou ST, Hsiao CC, Sheen JM, Cheng CN, Wu KH, Lin SR, Yu SL, Chen HY, Lu MY, Wang SC, Chang HH, Lin SW, Su YN, Lin DT. IKZF1 deletions predict a poor prognosis in children with B-cell progenitor acute lymphoblastic leukemia: a multicenter analysis in Taiwan. Cancer Sci. 2011; 102:1874-81.
  38. Lee WI*, Huang JL*, Jaing TH, Shyur SD, Yang KD, Chien YH, Chiang BL, Soong WJ, Chiou SS, Shieh CC, Lin SJ, Yeh KW, Chen LC, Ou LS, Yao TC, Lin TY, Chiu CH, Huang YC, Wu KH, Lin CY, Yu HH, Yang YH, Yu HR, Yen HJ, Hsieh MY, Kuo ML, Hwu WL, Tsai YC, Kuo HC, Lin YL, Shih YF, Chang KW. Distribution, clinical features and treatment in Taiwanese patients with symptomatic primary immunodeficiency diseases (PIDs) in a nationwide population-based study during 1985-2010. Immunobiology. 2011; 216:1286-94. (*corresponding author)
  39. Li YC, Chen CY, Huang MY, Wu KH, Yang WC, Wu HP. Significant change between primary and repeated serum laboratory tests at different time points in pediatric appendicitis. Eur J Emerg Med. 2011; 19:395-9.
  40. Yin-Yi Chang C, Wu KH, Lin TY, Chang WC, Lin WC, Hung YC, Yeh LS. Vulvar yolk sac tumor mixed with embryonal carcinoma in a peri-pubertal girl: A case report. Taiwan J Obstet Gynecol. 2011; 50:503-5.
  41. Wang CH, Wu KH, Yang YL, Peng CT, Tsai FJ, Lin DT, Chiu CF, Lin CC, Bau DT. Association between ataxia telangiectasia mutated gene polymorphisms and childhood leukemia in Taiwan. Chin J Physiol. 2011; 54:413-8.
  42. Chan CK, Wu KH＃, Lee SH, Hwang SM, Lee MS, Liao SK, Cheng EH, See LC, Tsai CN, Kuo ML, Huang JL. The comparison of interleukin-6 associated immunosuppressive effects of human ESCs, fetal-type MSCs, and adult-Type MSCs. Transplantion. 2012;94:132-8 (＃equally author)
  43. Weng TF, Ho MW, Lin HC, Lu MY, Peng CT, Wu KH*. Successful treatment of disseminated mixed invasive fungal infection after hematopoietic stem cell transplantation for severe aplastic anemia. Pediatr Transplant. 2012;16:35-8. (*corresponding author)
  44. Wu HP, Yang WC,Wu KH, Chen CY, Fu YC. Diagnosing appendicitis at different time points in children with right lower quadrant pain: comparison between pediatric appendicitis score and the alvarado score. World J Surg. 2012; 36:216-21.
  45. Chen CY, Yang WC, Wu KH, Wu HP. Clinical judgment of children with first-attack seizures admitted to the ED. Am J Emerg Med. 2012 Sep;30(7):1080-8.
  46. Yang YL, Hsiao CC, Chen HY, Lin KH, Jou ST, Chen JS, Chang TK, Sheen JM, Yu SL, Lu MY, Cheng CN, Wu KH, Wang SC, Wang JD, Chang HH, Lin SR, Lin SW, Lin DT. Absence of biallelic TCRγ deletion predicts introduction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia. Pediatr Blood Cancer. 2012;58:846-51.
  47. Chao YH, Wu HP, Chan CK, Tsai C, Peng CT, Wu KH*. Umbilical Cord-Derived Mesenchymal Stem Cells for Hematopoietic StemCell Transplantation. J Biomed Biotechnol. 2012; 2012:759503. (*corresponding author)
  48. Chao YH, Wu KH, Lu JJ, Shih MC, Peng CT, Chang CW. RBC alloimmunization among Chinese patients with β-thalassemia major in Taiwan. Blood Transfus. 2013;11:71-74.
  49. Wu KH, Tasi C, Wu HP, Sieber M, Chao YH, Peng CT. Human Application of Ex-Vivo Expanded Umbilical Cord-Derived Mesenchymal Stem Cells: Enhance Hematopoiesis after Cord Blood Transplantation. Cell Transplant. 2013;22:2041-51.
  50. Liu CH, Wu KH, Lin TY, Wei CC, Lin CY, Chen XX, Lee WI. Wiskott-Aldrich syndrome with IgA nephropathy: a case report and literature review. Int Urol Nephrol. 2013; 45:1495-500.
  51. Wu KH, Wang SM, Wu HP, Weng T, Peng CT, Chao YH. Autologous cord blood transplantation in a child with stage 4 neuroblastoma. Bone Marrow Transplant. 2013;48:317-8.
  52. Lin WC, Lin CH, Wu HP, Lin HC, Wu KH*. Simultaneous Pulmonary and Inferior Vena Cava Thromboembolism Secondary to Pelvic Osteosarcoma. J Pediatr Hematol Oncol. 2013;35:e320-2 (*corresponding author)
  53. Tamamyan G, Chao YH, Wang CH, Wu HP, Weng T, Peng CT, Wu KH*. Dasatinib Plus Chemotherapy to Achieve Full Donor Chimerism and Complete Molecular Remission in a Child with Relapsed Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 2013;60:1727-1728 (*corresponding author)
  54. Chen CY, Zhao LL, Lin YR, Wu KH, Wu HP*. Different urinalysis appearances in children with simple and perforated appendicitis. Am J Emerg Med. 2013; 31:1560-1563.
  55. Chao YH, Sheu JN, Chen SM, Wu KH*. Diagnostic Paracentesis in an Acute Lymphoblastic Leukemia Child without Characteristic Symptoms of Pancreatitis. Journal of Pediatric Hematology/Oncology. 2013; 35:e47-e47. (*corresponding author)
  56. WC Yang, YR Lin, LL Zhao, YK Wu, YJ Chang, CY Chen, KH Wu, HP Wu*. Epidemiology of Pediatric Critically-ill Patients Presenting to the Pediatric Emergency Department. Klinische Pediatrie. 2013;225:18-23.
  57. Sheu JN, Wu KH, Chen SM, Tsai JD, Chao YH, Lue KH*. Acute 99mTc DMSA Scan Predicts Dilating Vesicoureteral Reflux in Young Children With a First Febrile Urinary Tract Infection: A Population-Based Cohort Study. Clinical Nuclear Medicine. 2013; 38:163-168.
  58. Wu KH, Sheu JN, Wu HP, Tsai C, Sieber M, Peng CT, Chao YH*. Cotransplantation of Umbilical Cord-Derived Mesenchymal Stem Cells Promote Hematopoietic Engraftment in Cord Blood Transplantation: A Pilot Study. Transplantation. 2013; 95:773-7.
  59. Wang CH, Lai YL, Chang WS, Wu KH, Lane HY, Chiu CF, Tsai FJ, Lin CC, Bau DT. Significant Association of Caveolin-1 Single Nucleotide Polymorphisms with Childhood Leukemia in Taiwan. Cancer Genomics Proteomics. 2013;10:75-79.
  60. Wu KH, Wu HP, Chan CK, Hwang SM, Peng CT, Chao YH.The Role of Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation: from Bench to Bedsides. Cell Transplant. 2013;22:723-729.  
  61. Chen CY, Lin YR, Zhao LL, Wu YK, Chang YJ, Yang WC, Wu KH, Wu HP. Epidemiology and outcome analysis of children with traumatic out-of-hospital cardiac arrest compared to nontraumatic cardiac arrest. Pediatr Surg Int. 2013; 29:471-477.
  62. Sun HL, Wu KH, Chen SM, Chao YH, Ku MS, Hung TW, Liao PF, Lue KH, Sheu JN. Role of Procalcitonin in Predicting Dilating Vesicoureteral Reflux in Young Children Hospitalized. Pediatr Infect Dis J. 2013; 32:e348-e354.
  63. Chen CY, Lin YR, Zhao LL, Yang WC, Chang YJ, Wu KH, Wu HP. Clinical spectrum of rhabdomyolysis presented to pediatric emergency department. BMC Pediatrics. 2013; 13:1-6.
  64. Lin WC, Lin CH, Chao YH, Lin HC, Chen PY, Wu HP, Wu KH*. Simultaneous Pulmonary and Inferior Vena Cava Thromboembolism Secondary to Pelvic Osteosarcoma. J Pediatr Hematol Oncol. 2013; 35:e320-e322. (*corresponding author)
  65. Chao YH, Wu KH, Lin CY, Tsai MH, Peng CT, Wu HP, Lin CD. Audiologic and Vestibular Assessment in Patients With β-Thalassemia Major Receiving Long-Term Transfusion Therapy. Pediatr Blood Cancer. 2013;60:1963-6.  
  66. Wu KH, Chan CK, Chao YH, Peng CT, Huang JL. Clinical Consideration for Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation. Transplantation. 2013; 96:e86-e87.  
  67. Lin CY, Li MJ, Chang JG, Liu SC, Weng T, Wu KH, Yang SF, Huang FK, Lo WY, Peng CT. High-resolution melting analyses for genetic variants in ARID5B and IKZF1 with childhood acute lymphoblastic leukemia susceptibility loci in Taiwan. Blood Cells Mol Dis. 2014; 2014:140-145.
  68. Chao YH, Wu HP, Wu KH#, Tsai YG, Peng CT, Lin KC, Chao WR, Lee MS, Fu YC. An increase in CD3+CD4+CD25+ regulatory T cells after administration of umbilical cord-derived mesenchymal stem cells during sepsis. PLoS One. 2014; 9:e110338 (#equal contribution)
  69. Wu KH, Weng T, Wu HP, Peng CT, Sheu JN, Chao YH. Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: a pilot study. Pediatr Infect Dis J. 2014; 33:1193-5.
  70. Chao YH, Wu KH#, Wu HP, Liu SC, Peng CT, Lee MS. Clinical features and molecular analysis of Hb H disease in Taiwan. Biomed Res Int. 2014:271070. (#equal contribution)
  71. Cho FN, Chang TH, Shu CW, Ko MC, Liao SK, Wu KH, Yu MS, Lin SJ, Hong YC, Chen CH, Hung CH, Chang YH. Enhanced cytotoxicity of natural killer cells following the acquisition of chimeric antigen receptors through trogocytosis. PLoS One. 2014;9:e109352.
  72. Chao YH, Wu KH#, Chiou SH, Chiang SF, Huang CY, Yang HC, Chan CK, Peng CT, Wu HP, Chow KC, Lee MS. Downregulated CXCL12 expression in mesenchymal stem cells associated with severe aplastic anemia in children. Ann Hematol. 2015;94:13-22. (#equal contribution)
  73. Wu KH, Wu HP, Weng T, Peng CT, Chao YH. Dasatinib for a child with Philadelphia chromosome-positive acute lymphoblastic leukemia and persistently elevated minimal residual disease during imatinib therapy. Curr Oncol. 2015; 22:303-306.
  74. Li YC, Chen CY, Wu KH, Kuo HT, Wu HP. Recurrent Streptococcus Pneumoniae 23 F meningitis due to cerebrospinal fluid leakage from the ear cannel: a case report. BMC Pediatr. 2015;15:195.
  75. Lin CH, Lin WC, Lai IH, Wu SF, Wu KH, Chen AC. Pediatric gastric cancer presenting with massive ascites. World J Gastroenterol. 2015;21:3409-13.
  76. Wu KH, Chao WR, Lo WY, Tseng PC, Lee CJ, Peng CT, Lee MS, Wu HP, Chao YH. Time-Series Expression of Toll-Like Receptor 4 Signaling in Septic Mice Treated With Mesenchymal Stem Cells. Shock. 2016;45:634-40.
  77. Yen HJ, Chang WH, Liu HC, Yeh TC, Hung GY, Wu KH, Peng CT, Chang YH, Chang TK, Hsiao CC, Sheen JM, Chao YH, Chang TT, Chiou SS, Lin PC, Wang SC, Lin MT, Ho WL, Chen YC, Liang DC. Outcomes Following Discontinuation of E. coli l-Asparaginase Upon Severe Allergic Reactions in Children With Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 2016;63:665-70.
  78. Weng TF, Wu KH#, Wu HP, Peng CT, Chao YH. Changes of serum aspergillus galactomannan during hematopoietic stem cell transplantation in children with prior invasive aspergillosis. Ital J Pediatr. 2016;42:30. (#equal contribution)
  79. Chen CY, Kuo HT, Chang YJ, Wu KH, Yang WC, Wu HP. Clinical assessment of children with renal abscesses presenting to the pediatric emergency department. BMC Pediatr. 2016;16:189.
  80. Wu KH, Wu HP, Lin HJ, Wang CH, Chen HY, Weng T, Peng CT, Chao YH. Concurrent hypopituitarism and leukemic retinopathy in a child with B-precursor acute lymphoblastic leukemia and isolated central nervous system relapse. Curr Oncol. 2016;23:e431-4.
  81. Chuncharunee S, Wong R, Rojnuckarin P, Chang CS, Chang KM, Lu MY, Hwang WL, Koh LP, Chen TY, Leung AY, Norasetthada L, Wang SC, Chang MC, Wu KH, Issaragrisil S. Efficacy of rabbit antithymocyte globulin as first-line treatment of severe aplastic anemia: an Asian multicenter retrospective study. Int J Hematol. 2016;104:454-61.
  82. Lin HC, Chao YH, Wu KH, Yen TY, Hsu YL, Hsieh TH, Wei HM, Wu JL, Muo CH, Hwang KP, Peng CT, Lin CC, Li TC. Increased risk of herpes zoster in children with cancer: A nationwide population-based cohort study. Medicine (Baltimore). 2016; 95:e4037.
  83. Chan CK, Lin TC, Huang YA, Chen YS, Wu CL, Lo HY, Kuo ML, Wu KH*, Huang JL. The modulation of Th2 immune pathway in the immunosuppressive effect of human umbilical cord mesenchymal stem cells in a murine asthmatic model. Inflamm Res. 2016;65:795-801. (*corresponding author)
  84. Yang CA, Lin JA, Chang CW, Wu KH, Yeh SP, Ho CM, Chang JG. Selection of GP. Mur antigen-negative RBC for blood recipients with anti-‘Mia ‘ records decreases transfusion reaction rates in Taiwan. Transfus Med. 2016;26:349-354.
  85. Huang MY, Chen CY, Chien JH, Wu KH, Chang Y, Wu KH, Wu HP. Serum Procalcitonin and Procalcitonin Clearance as a Prognostic Biomarker in Patients with Severe Sepsis and Septic Shock. Biomed Res Int. 2016;2016:1758501.
  86. Lin CH, Chao YH, Wu KH, Lin WC. Primary mucoepidermoid carcinoma at the carina of trachea presenting with wheezing in an asthmatic child mimicking an attack of asthma: A case report. Medicine (Baltimore). 2016;95:e5292.
  87. Yang WC, Kuo HT, Lin CH, Wu KH, Chang YJ, Chen CY, Wu HP. Tympanic temperature versus temporal temperature in patients with pyrexia and chills. Medicine (Baltimore). 2016;95:e5267.
  88. Wu HP, Lin CL, Chang YC, Wu KH, Lei RL, Peng CT, Weng T, Tai YM, Chao YH. Survival and complication rates in patients with thalassemia major in Taiwan. Pediatr Blood Cancer. 2017;64:135-8.
  89. Li MJ, Liu HC, Yen HJ, Jaing TH, Lin DT, Yang CP, Lin KH, Hung IJ, Jou ST, Lu MY, Hsiao CC, Peng CT, Chang TT, Wang SC, Lin MT, Chen JS, Chang TK, Hung GY, Wu KH, Yang YL, Chang HH, Chen SH, Yeh TC, Cheng CN, Lin PC, Chiou SS, Sheen JM, Cheng SN, Chen SH, Chang YH, Ho WL, Chao YH, Chen RL, Chen BW, Wang JL, Hsieh YL, Liao YM, Yang SH, Chang WH, Chao YY, Liang DC. Treatment for childhood acute lymphoblastic leukemia in Taiwan: Taiwan Pediatric Oncology Group ALL-2002 study emphasizing optimal reinduction therapy and central nervous system preventive therapy without cranial radiation. Pediatr Blood Cancer. 2017;64:234-241.
  90. Sun KT, Huang YN, Palanisamy K, Chang SS, Wang IK, Wu KH, Chen P, Peng CT, Li CY. Reciprocal regulation of γ-globin expression by exo-miRNAs: Relevance to γ-globin silencing in β-thalassemia major. Sci Rep. 2017;7:202.
  91. Wu HP, Lin MJ, Yang WC, Wu KH, Chen CY. Predictors of Extracorporeal Membrane Oxygenation Support for Children with Acute Myocarditis. Biomed Res Int. 2017:2510695.
  92. Chang YH, Yu MS, Wu KH, Hsu MC, Chiou YH, Wu HP, Peng CT, Chao YH. Effectiveness of Parenteral Glutamine on Methotrexate-induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia. Nutr Cancer. 2017l;69:746-51.
  93. Yen HJ, Chen SH, Chang TY, Yang CP, Lin DT, Hung IJ, Lin KH, Chen JS, Hsiao CC, Chang TT, Chang TK, Peng CT, Lin MT, Jaing TH, Liu HC, Jou ST, Lu MY, Cheng CN, Sheen JM, Chiou SS, Hung GY, Wu KH, Yeh TC, Wang SC, Chen RL, Chang HH, Yang YL, Chen SH, Cheng SN, Chang YH, Chen BW, Hsieh YL, Huang FL, Ho WL, Wang JL, Chang CY, Chao YH, Lin PC, Chen YC, Liao YM, Lin TH, Shih LY, Liang DC. Pediatric acute lymphoblastic leukemia with t(1;19)/TCF3-PBX1 in Taiwan. Pediatr Blood Cancer. 2017;64:e26557.
  94. Chao YH, Wu KH, Lin CW, Yang SF, Chao WR, Peng CT, Wu HP. PG2, a botanically derived drug extracted from Astragalus membranaceus, promotes proliferation and immunosuppression of umbilical cord-derived mesenchymal stem cells. J Ethnopharmacol. 2017;207:184-91.
  95. Chao YH, Chang YC, Wu HP, Peng CT, Weng TF, Wu KH*. Everolimus for pediatric patients with acute graft-versus-host disease after hematopoietic stem cell transplantation: A pilot study. Medicine (Baltimore). 2017;96:e8464. (*corresponding author)
  96. Chao YH, Lin CW, Pan HH, Yang SF, Weng TF, Peng CT, Wu KH*. Increased apoptosis and peripheral blood mononuclear cell suppression of bone marrow mesenchymal stem cells in severe aplastic anemia. Pediatr Blood Cancer. 2018; e27247. (*corresponding author)
  97. Yeh TC, Liang DC, Hou JY, Jaing TH, Lin DT, Yang CP, Peng CT, Hung IJ, Lin KH, Hsiao CC, Jou ST, Chiou SS, Chen JS, Wang SC, Chang TK, Wu KH, Sheen JM, Yen HJ, Chen SH, Lu MY, Li MJ, Chang TT, Huang TH, Chang YH, Chen SH, Yang YL, Chang HH, Chen BW, Lin PC, Cheng CN, Chao YH, Yang SH, Chao YY, Liu HC. Treatment of childhood acute lymphoblastic leukemia with delayed first intrathecal therapy and omission of prophylactic cranial irradiation: Results of the TPOG-ALL-2002 study. Cancer. 2018;124:4538-4547.
  98. Lin CH, Chen X, Wu CC, Wu KH, Song TS, Weng TF, Hsieh YW, Peng CT. Therapeutic mechanism of combined oral chelation therapy to maximize efficacy of iron removal in transfusion-dependent thalassemia major – a pilot study. Expert Rev Hematol. 2019;12:265-272.
  99. Wang HH, Liao LN, Chang CW, Chang YC, Wu KH, Ko JL. The alteration of ferritin and transferrin saturation under body mass index and blood pressure in first-time and regular male blood donors in Taiwan. Medicine (Baltimore). 2019;98:e15854.
  100. Chen SH, Chen JS, Jou ST, Wu KH, Hung IJ, Sheen JM, Lu MY, Chen BW, Jaing TH, Wang SC, Lin MT, Chang TK, Liu HC, Yang CP. Outcome and prognosis of anaplastic large cell lymphoma in children: a report from the Taiwan Pediatric Oncology Group. Leuk Lymphoma. 2019;60:1942-1949.
  101. Chen CH, Wu KH, Chao YH, Weng DF, Chang JS, Lin CH. Clinical manifestation of pediatric mediastinal tumors, a single center experience. Medicine (Baltimore). 2019;98:e16732.
  102. Chao YH, Wu KH. Transfusion-related immunomodulation in pediatric patients. Pediatr Neonatol. 2019;60:483-484.
  103. Yu CH, Chang WT, Jou ST, Lin TK, Chang YH, Lin CY, Lin KH, Lu MY, Chen SH, Wu KH, Wang SC, Chang HH, Su YN, Hung CC, Lin DT, Chen HY, Yang YL. TP53 alterations in relapsed childhood acute lymphoblastic leukemia. Cancer Sci. 2020;111:229-238.
  104. Wu KH, Cheng CC, Li JP, Weng TF, Yang SF, Pan HH, Chao YH. Toll-like receptor signalling associated with immunomodulation of umbilical cord–derived mesenchymal stem cells in mice with systemic lupus erythematosus. Lupus. 2020;29:165-175.
  105. Hsia NY, Lin CJ, Lin HJ, Wu KH. Foveal photoreceptors loss and then recovery after treatment in a chronic myelogenous leukemia patient. Pediatr Hematol Oncol. 2020;37:545-548.
  106. Yu CH, Lin TK, Jou ST, Lin CY, Lin KH, Lu MY, Chen SH, Cheng CN, Wu KH, Wang SC, Chang HH, Li MJ, Ni YL, Su YN, Lin DT, Chen HY, Harrison CJ, Hung CC, Lin SW, Yang YL. MLPA and DNA index improve the molecular diagnosis of childhood B-cell acute lymphoblastic leukemia. Sci Rep. 2020;10:11501.
  107. Yu SL, Zhang H, Ho BC, Yu CH, Chang CC, Hsu YC, Ni YL, Lin KH, Jou ST, Lu MY, Chen SH, Wu KH, Wang SC, Chang HH, Pui CH, Yang JJ, Zhang J, Lin DT, Lin SW, Ma X, Yang YL. FPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia. Sci Rep. 2020;10:12074.
  108. Chuang TY, Li JP, Weng TF, Wu KH, Chao YH. Combined chelation with high-dose deferiprone and deferoxamine to improve survival and restore cardiac function effectively in patients with transfusion-dependent thalassemia presenting severe cardiac complications. Ann Hematol. 2020 Jul 31. in press

國際知名SCI醫學期刊論文審稿學者(reviewer):

  1. Pediatrics
  2. Cell transplantation
  3. Transplantation
  4. Annals of Hematology
  5. Stem Cells International, Acta Haematologica
  6. Cell Biochemistry and Biophysics
  7. Journal of the Chinese Medical Association
  8. Mycopathologia
  9. Journal of the Formosan Medical Association
  10. Pediatrics and Neonatology.
Chung Shan Medical University Hospital

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