| 現職： | – 中山醫學大學附設醫院骨科主治醫師 – 中山醫學大學運動醫學科主任 – 教育部部定教授 |
| 專長： | 關節鏡手術、人工關節置換手術、關節疾病、運動傷害、骨質疏鬆 |
| 近五年論文著作： | • Lu KH, Wang SI, Yang SF. Real-World Evidence Indicates Romosozumab Use Is Associated with a Greater Reduction in Osteoporotic Fractures Than PTH (1–34) Analogs in Women. Biol Sex Differ 2025 Dec (Accepted) (SCI, 2024 IF: 5.1; 12.8%) • Chou CH, Hsieh YH, Chen PN, Yang JS, Tang CH, Yang SF, Lu KH. Suppression of pentraxin 3 inhibits human osteosarcoma cell metastasis by repressing MAZ through STAT3 pathway. Cancer Cell Int 2025 Oct;25(1):359. doi: 10.1186/s12935-025-04008-1. (SCI, IF: 6.0; Ranking: 55/328: 16.6%). (2024) • Yang JS, Chou CH, Hsieh YH, Tang CH, Lu KH, Yang SF. Carbonic Anhydrase IX Induces Human Osteosarcoma Cell Metastasis by Activating HSPA6 Expression Through the AMPK Signalling Pathway. J Cell Mol Med 2025 Aug;29(15):e70763. doi: 10.1111/jcmm.70763. (SCI, IF: 4.2; Ranking: 85/204: 41.4%). (2024) • Lu KH, Hsieh YH, Lin RC, Tsai MY, Yang SF. Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms. J Pineal Res 2025 Jul;77(4):e70062. doi: 10.1111/jpi.70062. (SCI, IF: 6.3; Ranking: 24/193: 12.2%). (2024) • Lu KH, Wang SI, Yang SF. Denosumab withdrawal increases vertebral fracture and mortality risk compared with zoledronate. Eur J Endocrinol 2025 Mar 3;192(3):180-190. doi: 10.1093/ejendo/lvaf013. (SCI, IF: 5.3; Ranking: 27/186: 14.2%). (2023) • Lin YH, Yang JS, Chou CH, Huang TY, Yang SF, Lu KH. Curcumin Analog GO-Y030 Triggers JNK and p38 Signalling to Activate Apoptotic Cascades in Human Osteosarcoma Cells. J Cell Mol Med 2025 Feb;29(3):e70383. doi: 10.1111/jcmm.70383. (4.3; Ranking: 58/189: 30.4%). (2023) • Yang JS, Chou CH, Hsieh YH, Lu PW, Lin YC, Yang SF, Lu KH. Morin inhibits osteosarcoma migration and invasion by suppressing urokinase plasminogen activator through a signal transducer and an activator of transcription 3. Environ Toxicol 2024 Apr;39(4):2024-2031. doi: 10.1002/tox.24100. (SCI, IF: 4.4; Ranking: 18/106: 16.5%). (2023) • Hsieh MH, Hsieh YH, Chou CH, Yang JS, Lu PW, Huang TY, Yang SF, Lu KH. Apoptotic effect and cell arrest of deoxyshikonin in human osteosarcoma cells through the p38 pathway. J Cell Mol Med 2023 Jun;27(11):1592-1602. doi: 10.1111/jcmm.17764. (SCI, IF: 5.3; Ranking: 41/136: 34.2%). (2022) • Lu KH, Lu PW, Lin CW, Lu EW, Yang SF. Different molecular weights of hyaluronan research in knee osteoarthritis: A state-of-the-art review. Matrix Biol 2023 Mar;117:46-71. doi: 10.1016/j.matbio.2023.02.006. (SCI, IF: 10.45; Ranking: 29/297: 9.76%). (2021) • Lu KH, Lu PW, Lu EW, Lin CW, Yang SF. Curcumin and its Analogs and Carriers: Potential Therapeutic Strategies for Human Osteosarcoma. Int J Biol Sci 2023 Feb 13;19(4):1241-1265. doi: 10.7150/ijbs.80590. eCollection 2023. (SCI, IF: 10.75; Ranking: 28/297: 9.43%). (2021) • Lu KH, Lu PW, Lin CW, Yang SF. Curcumin in human osteosarcoma: From analogs to carriers. Drug Discov Today 2023 Feb;28(2):103437. doi: 10.1016/j.drudis.2022.103437. (SCI, IF: 8.369; Ranking: 20/279: 7.17%). (2021) • Lu PW, Chou CH, Yang JS, Hsieh YH, Tsai MY, Lu KH, Yang SF. HO-3867 Induces Apoptosis via the JNK Signaling Pathway in Human Osteosarcoma Cells. Pharmaceutics 2022 Jun 13;14(6):1257. doi: 10.3390/pharmaceutics14061257. (SCI, IF: 6.525; Ranking: 39/279: 14.0%). (2021) • Yeh LT, Lin CW, Lu KH, Hsieh YH, Yeh CB, Yang SF, Yang JS. Niclosamide Suppresses Migration and Invasion of Human Osteosarcoma Cells by Repressing TGFBI Expression via the ERK Signaling Pathway. Int J Mol Sci 2022 Jan 1;23(1):484. doi: 10.3390/ijms23010484. (SCI, IF: 10.45; Ranking: 29/297: 9.76%). (2021) • Lu KH, Lu PW, Lu EWH, Tang CH, Su SH, Lin CW, Yang SF. The potential remedy of melatonin on osteoarthritis. J Pineal Res 2021 Oct;71(3):e12762. doi: 10.1111/jpi.12762. Epub 2021 Sep 5. PMID: 34435392 (SCI, IF: 13.007; Ranking: 12/273: 5.21%). (2020) • Chou CH, Lu KH, Yang JS, Hsieh YH, Lin CW, Yang SF. Dihydromyricetin suppresses cell metastasis in human osteosarcoma through SP-1- and NF-kappaB-modulated urokinase plasminogen activator inhibition. Phytomedicine 2021 Sep:90:153642. doi: 10.1016/j.phymed.2021.153642. (SCI, IF: 5.340; Ranking: 3/28: 9.93%). (2020) • Lu KH, Yang JS, Hsieh YH, Chu HJ, Chou CH, Lu EW, Lin CW, Yang SF. Lipocalin-2 Inhibits Osteosarcoma Cell Metastasis by Suppressing MET Expression via the MEK-ERK Pathway. Cancers (Basel) 2021 Jun 25;13(13):3181. doi: 10.3390/cancers13133181. PMID: 34202288. (SCI, IF: 6.639; Ranking: 51/242: 20.87%). (2020) • Lu PW, Lin RC, Yang JS, Lu EW, Hsieh YH, Tsai MY, Lu KH, Yang SF. GO-Y078, a Curcumin Analog, Induces Both Apoptotic Pathways in Human Osteosarcoma Cells via Activation of JNK and p38 Signaling. Pharmaceuticals (Basel) 2021 May 24;14(6):497. doi: 10.3390/ph14060497. (SCI, IF: 5.863; Ranking: 38/276: 13.59%). (2020) • Hsieh YH, Hsu WH, Yang SF, Liu CJ, Lu KH, Wang PH, Lin RC*. Potential Antimetastatic Effect of Timosaponin AIII against Human Osteosarcoma Cells through Regulating the Integrin/FAK/Cofilin Axis. Pharmaceuticals (Basel) 2021 Mar 14;14(3):260. doi: 10.3390/ph14030260. (SCI, IF: 5.863; Ranking: 38/276: 13.59%). (2020) |