巫康熙主治醫師
| 現職 | 中山醫學大學附設醫院兒童血液腫瘤科主任 |
| 專長 | 骨髓移植，幹細胞 |
| 執行臨床試驗案件數(近五年) | 3件 |
| 聯繫方式 | 聯繫電話：04-24739595#21755 聯繫信箱：cshy1903@gmail.com |
| 近五年論文著作 |
| 《2020》 1. Yu CH, Chang WT, Jou ST, Lin TK, Chang YH, Lin CY, Lin KH, Lu MY, Chen SH, Wu KH, Wang SC, Chang HH, Su YN, Hung CC, Lin DT, Chen HY, Yang YL. TP53 alterations in relapsed childhood acute lymphoblastic leukemia. Cancer Sci. 2020;111:229-238. 2. Wu KH, Cheng CC, Li JP, Weng TF, Yang SF, Pan HH, Chao YH. Toll-like receptor signalling associated with immunomodulation of umbilical cord–derived mesenchymal stem cells in mice with systemic lupus erythematosus. Lupus. 2020;29:165-175. 3. Hsia NY, Lin CJ, Lin HJ, Wu KH. Foveal photoreceptors loss and then recovery after treatment in a chronic myelogenous leukemia patient. Pediatr Hematol Oncol. 2020;37:545-548. 4. Yu CH, Lin TK, Jou ST, Lin CY, Lin KH, Lu MY, Chen SH, Cheng CN, Wu KH, Wang SC, Chang HH, Li MJ, Ni YL, Su YN, Lin DT, Chen HY, Harrison CJ, Hung CC, Lin SW, Yang YL. MLPA and DNA index improve the molecular diagnosis of childhood B-cell acute lymphoblastic leukemia. Sci Rep. 2020;10:11501. 5. Yu SL, Zhang H, Ho BC, Yu CH, Chang CC, Hsu YC, Ni YL, Lin KH, Jou ST, Lu MY, Chen SH, Wu KH, Wang SC, Chang HH, Pui CH, Yang JJ, Zhang J, Lin DT, Lin SW, Ma X, Yang YL. FPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia. Sci Rep. 2020;10:12074. 6. Chuang TY, Li JP, Weng TF, Wu KH, Chao YH. Combined chelation with high-dose deferiprone and deferoxamine to improve survival and restore cardiac function effectively in patients with transfusion-dependent thalassemia presenting severe cardiac complications. Ann Hematol. 2020;99:2289-2294. 7. Yu CH, Lin TK, Jou ST, Lin CY, Lin KH, Lu MY, Chen SH, Cheng CN, Wu KH, Wang SC, Chang HH, Li MJ, Ni YL, Su YN, Lin DT, Chen HY, Harrison CJ, Hung CC, Lin SW, Yang YL. MLPA and DNA index improve the molecular diagnosis of childhood B-cell acute lymphoblastic leukemia. Sci Rep. 2020;10:11501. 8. Yu CH, Chang YH, Wang DS, Jou ST, Lin CY, Lin KH, Lu MY, Raghav L, Chang HH, Wu KH, Chou SW, Ni YL, Lin DT, Lin SW, Chen HY, Yang YL. Determination of NUDT15 variants by targeted sequencing can identify compound heterozygosity in pediatric acute lymphoblastic leukemia patients. Sci Rep. 2020;10:14400. 《2021》 9. Yang KL, Wu KH, Lin PY. HLA-A*11:77, a variant of HLA-A*11, detected in a Taiwanese patient. HLA. 2021;97:445-446. 10. Chang YH, Yu CH, Jou ST, Lin CY, Lin KH, Lu MY, Wu KH, Chang HH, Lin DT, Lin SW, Chen HY, Yang YL. Targeted sequencing to identify genetic alterations and prognostic markers in pediatric T-cell acute lymphoblastic leukemia. Sci Rep. 2021;11:769. 11. Hsu YC, Yu CH, Chen YM, Roberts KG, Ni YL, Lin KH, Jou ST, Lu MY, Chen SH, Wu KH, Chang HH, Lin DT, Lin SW, Lin ZS, Chiu WT, Chang CC, Ho BC, Mullighan CG, Yu SL, Yang YL. Philadelphia chromosome-negative B-cell acute lymphoblastic leukaemia with kinase fusions in Taiwan. Sci Rep. 2021;11:5802. 12. Yang YL, Jaing TH, Chen SH, Liu HC, Hung IJ, Lin DT, Yang CP, Peng CT, Lin KH, Hsiao CC, Jou ST, Chen JS, Lin MT, Wang SC, Chang TK, Huang FL, Cheng CN, Wu KH, Sheen JM, Chen SH, Lu MY, Hung GY, Yen HJ, Hsieh YL, Wang JL, Chang YH, Chang HH, Yeh TC, Weng TF, Hou JY, Chen BW, Chen RL, Wang LY, Ho WL, Chen YC, Cheng SN, Chao YH, Yang SH, Huang TH, Chou SW, Lin CY, Chen HY, Chao YY, Liang DC, Chang TT. Treatment outcomes of pediatric acute myeloid leukemia: a retrospective analysis from 1996 to 2019 in Taiwan. Sci Rep. 2021;11:5893. 13. Lee CC, Hsu TC, Kuo CC, Liu MA, Abdelfattah AM, Chang CN, Yao M, Li CC, Wu KH, Chen TC, Gau JP, Wang PN, Liu YC, Chiou LW, Lee MY, Li SS, Chao TY, Jou ST, Chang HH. Validation of a Post-Transplant Lymphoproliferative Disorder Risk Prediction Score and Derivation of a New Prediction Score Using a National Bone Marrow Transplant Registry Database. Oncologist. 2021;26:e2034-e2041. 14. Huang YJ, Liu HC, Jaing TH, Wu KH, Wang SC, Yen HJ, Hsiao CC, Chen SH, Lin PC, Yeh TC, Sheen JM, Chen YC, Chang TK, Huang FL, Chao YH, Hou JY, Yang CP, Lin TH, Shih LY. RAS pathway mutation is an added-value biomarker in pediatric Philadelphia-negative B-cell acute lymphoblastic leukemia with IKZF1 deletions. Pediatr Blood Cancer. 2021;68:e28899. 15. Ho WL, Hung GY, Yen HJ, Yang YL, Chang HH, Lu MY, Lin KH, Chen JS, Cheng CN, Hung IJ, Yang CP, Chen SH, Liu HC, Yeh TC, Hou JY, Hsiao CC, Sheen JM, Chang TT, Wong TT, Miser JS, Liu YL, Chen RL, Chen BW, Peng CT, Chang TK, Wu KH, Chang YH, Wang JL, Wang SC, Lin MT, Hu FC, Jou ST, Lin DT. Characteristics and outcomes of second cancers in patients with childhood cancer: A report from the Taiwan Pediatric Oncology Group. J Formos Med Assoc. 2021;S0929-6646:00227-8. 16. Huang YJ, Kuo MC, Jaing TH, Liu HC, Yeh TC, Chen SH, Lin TL, Yang CP, Wang PN, Sheen JM, Chang TK, Chang CH, Hu SF, Huang TY, Wang SC, Wu KH, Chiou SS, Hsiao CC, Shih LY. Comparison of Two Quantitative PCR-Based Assays for Detection of Minimal Residual Disease in B-Precursor Acute Lymphoblastic Leukemia Harboring Three Major Fusion Transcripts. J Mol Diagn. 2021;23:1373-1379. 《2022》 17. Weng TF, Wu KH. Haploidentical peripheral blood stem cell transplantation with posttransplant cyclophosphamide in a child with neuroblastoma relapse after autologous peripheral blood stem cell transplantation. Pediatr Blood Cancer. 2022 ; 69: e29439. 18. Wu KH, Chao YH, Weng TF, Li JP. Clinical Consideration for Mesenchymal Stem Cells in Treatment of COVID-19. Curr Pharm Des. 2022; 28: 2991-2994. 19. Yu CH, Wu G, Chang CC, Jou ST, Lu MY, Lin KH, Chen SH, Wu KH, Huang FL, Cheng CN, Chang HH, Dale Hedges, Wang HL, Yen HJ, Li MJ, Chou SW, Hung CT, Lin ZS, Lin CY, Chen HY, Ni YZ, Hsu YC, Lin DT, Lin SW, Yang JJ, Pui CH, Yu SL, Yang YL. Sequential approach to improve the molecular classification of childhood acute lymphoblastic leukemia. J Mol Diagn. 2022; 10; S1525-1578. 20. Li JP, Wu KH, Chao WR, Lee YJ, Yang SF, Chao YH. Immunomodulation of Mesenchymal Stem Cells in Acute Lung Injury: From Preclinical Animal Models to Treatment of Severe COVID-19. Int J Mol Sci. 2022; 23: 8196. 21. Lee WL, Wu KH, Wei CC. Evaluating Accuracy of Medical Information Distribution Regarding Risk of COVID-19 Infections and Childhood Cancer Survivors. J Clin Oncol. 2022; 40: 3225-3226. 22. Yu CH, Wu G, Chang CC, Jou ST, Lu MY, Lin KH, Chen SH, Wu KH, Huang FL, Cheng CN, Chang HH, Dale Hedges, Wang JL, Yen HJ, Li MJ, Chou SW, Hung CT, Lin ZS, Lin CY, Chen HU, Ni YL, Hsu YC, Lin DT, Lin SW, Yang JJ, Pui CH, Yu SL, Yang YL. Sequential Approach to Improve the Molecular Classification of Childhood Acute Lymphoblastic Leukemia. J Mol Diagn. 2022 ; 24: 1195-1206. 23. Huang TH, Hung GY, Weng TF, Wang FM, Lee CY, Lin DT, Chen BW, Lin KH, Wu KH, Liu HC, Chen JS, Jou ST, Hou JY, Yang YL, Chen SH, Chang HH, Chiou SS, Lin PC, Chen RL, Hsiao CC, Yen HJ, Yang CP, Chang TK, Lu MY, Cheng CN, Sheen JM, Liao YM, Su MY, Yeh TC. Surgical treatment confers prognostic significance in pediatric malignant mediastinal germ cell tumors. Cancer. 2022; 128: 4139-4149. 24. Wu KH, Li JP, Chao WR, Lee YJ, Yang SF, Cheng CC, Chao YH. Immunomodulation via MyD88-NFκB incidence and predictors Pathway from Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury. Int J Mol Sci. 2022 ; 23: 5295. 25. Wu KH, Weng TF, Li JP, Chao YH. Antithymocyte Globulin Plus Post-Transplant Cyclophosphamide Combination as an Effective Strategy for Graft-versus-Host Disease Prevention in Haploidentical Peripheral Blood Stem Cell Transplantation for Children with High-Risk Malignancies. Pharmaceuticals 2022; 15: 1423. 26. Liu MA, Lee CC, Phung Q, Dao QL, Tehrani B, Yao M, Li CC, Wu KH, Chen TC, Gau JP, Li SS, Wang PN, Liu YC, Wang TF, Chiou LW, Lee MY, Yu MS, Wang CC, Lin SC, Chen YC, Chao TY, Ma MC, Chen CC, Chang HH. Incidence and predictors of idiopathic pneumonia syndrome in hematopoietic stem cell transplant patients: a nationwide registry study. Int J Hematol 2022; 116: 770-777 27. Ho WL, Hung GY, Yen HJ, Yang YL, Chang HH, Lu MY, Lin KH, Chen JS, Cheng CN, Hung IJ, Yang CP, Chen SH, Liu HC, Yeh TC, Hou JY, Hsiao CC, Sheen JM, Chang TT, Wong TT, James S Miser, Liu YL, Chen RL, Chen BW, Peng CT, Chang TK, Wu KH, Chang YH, Wang JL, Wang SC, Lin MT, Hu FC, Jou ST, Lin DT. Characteristics and outcomes of second cancers in patients with childhood cancer: A report from the Taiwan Pediatric Oncology Group. J Formos Med Assoc 2022; 121: 350-359. 《2023》 28. Yu CH, Jou ST, Su YH, Elane CS, Wu G, Cheng CN, Lu MY, Lin KH, Wu KH, Chen SH, Huang FL, Chang HH, Wang JL, Yen HJ, Li MJ, Chou SW, Ho WL, Liu YL, Chang CC, Lin ZS, Lin CY, Chen HY, Ni YL, Lin DT, Lin SW, Yang JJ, Ni YH, Pui CH, Yu SL, Yang YL. Clinical impact of minimal residual disease and genetic subtypes on the prognosis of childhood acute lymphoblastic leukemia. Cancer. 2023 ; 129: 790-802. 29. Li JP, Wu KH, Chao WR, Lee YJ, Yang SF, Chao YH. Alterations of mesenchymal stem cells on regulating Th17 and Treg differentiation in severe aplastic anemia. Aging (Albany NY). 2023; 15: 553-566. 30. Wang XA, Li JP, Wu KH, Yang SF, Chao YH. Mesenchymal Stem Cells in Acquired Aplastic Anemia: The Spectrum from Basic to Clinical Utility. Int J Mol Sci. 2023 ; 24: 4464. 31. Liu HC, Kuo MC, Wu KH, Chen TY, Chen JS, Wang MC, Lin TL, Yang YS, Ma MC, Wang PN, Sheen JM, Wang SC, Chen SH, Jaing TH, Cheng CN, Yeh TC, Lin TH, Shih LY. Children with chronic myeloid leukaemia treated with front-line imatinib have a slower molecular response and comparable survival compared with adults: a multicenter experience in Taiwan. Br J Cancer. 2023; 128: 1294-1300. 32. Yu CH, Chang YH, Wang DS, Jou ST, Lin CY, Lin KH, Lu MY, Wu KH, Cheng CN, Chang HH, Chou SW, Su MY, Ni YL, Xu PY, Lin DT, Lin SW, Chen HY, Yang YL. Allele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia. Sci Rep. 2023 ; 13: 490. 33. Lin WY, Wu KH, Chen CY, Guo BC, Chang YJ, Lee TA, Lin MJ, Wu HP. Stem Cell Therapy in Children with Traumatic Brain Injury. Int J Mol Sci. 2023; 24: 14706. 34. Guo BC, Wu KH, Chen CY, Lin WY, Chang YJ, Lee TA, Lin MJ, Wu HP. Mesenchymal Stem Cells in the Treatment of COVID-19. Int J Mol Sci. 2023; 24: 14800. 《2024》 35. Guo BC, Wu KH, Chen CY, Lin WY, Chang YJ, Lin MJ, Wu HP. Advancements in Allergen Immunotherapy for the Treatment of Atopic Dermatitis. Int J Mol Sci. 2024 Jan 21;25(2):1316. 36. Liu HC, Huang YJ, Jaing TH, Wu KH, Chen SH, Wang SC, Yeh TC, Hsiao CC, Chang TK, Yen HJ, Huang FL, Lin PC, Hou JY, Sheen JM, Liao YM, Chang TY, Chen YC, Chiou SS, Yang CP, Pui CH, Liang DC, Shih LY. Refining risk stratification in paediatric B-acute lymphoblastic leukaemia: Combining IKZF1plus and Day 15 MRD positivity. Br J Haematol. 2024 Apr;204(4):1344-1353. 37. Lin WY, Wu KH, Chen CY, Guo BC, Chang YJ, Lin MJ, Wu HP. Treatment of Undifferentiated Embryonal Sarcoma of the Liver in Children. Cancers (Basel). 2024 Feb 23;16(5):897. 38. Wu CH, Weng TF, Li JP, Wu KH. Biology and Therapeutic Properties of Mesenchymal Stem Cells in Leukemia. Int J Mol Sci. 2024 Feb 21;25(5):2527. 39. Chen YH, Wu KH, Wu HP. Unraveling the Complexities of Toll-like Receptors: From Molecular Mechanisms to Clinical Applications. Int J Mol Sci. 2024 May 5;25(9):5037. |