{"id":6411,"date":"2026-10-01T11:16:06","date_gmt":"2026-10-01T03:16:06","guid":{"rendered":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/?p=6411"},"modified":"2026-10-01T11:16:08","modified_gmt":"2026-10-01T03:16:08","slug":"%e8%95%81%e9%ba%bb%e7%96%b9%ef%bc%8c%e7%99%a2%e7%99%a2%e7%99%a2%ef%bc%81btk%e6%b2%bb%e7%99%82%e6%96%b0%e6%9b%99%e5%85%89%ef%bc%81","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/?p=6411","title":{"rendered":"\u8541\u9ebb\u75b9\uff0c\u7662\u7662\u7662\uff01BTK\u6cbb\u7642\u65b0\u66d9\u5149\uff01"},"content":{"rendered":"\n

\u6587\/\u76ae\u819a\u79d1 \u856d\u7389\u5c4f\u6559\u6388<\/p>\n\n\n

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\"\"<\/figure><\/div>\n\n\n

\u3000\u3000\u8541\u9ebb\u75b9\u662f\u4e00\u7a2e\u5e38\u898b\u7684\u76ae\u819a\u75be\u75c5\uff0c\u5e38\u5e38\u662f\u7a81\u7136\u5f88\u7662\uff0c\u63a5\u8457\u51fa\u73fe\u50cf\u868a\u5b50\u54ac\u4e00\u6a23\uff0c\u4e00\u584a\u4e00\u584a\u816b\u8d77\u4f86\u7684\u98a8\u75b9 (\u53c8\u7a31\u70ba\u81a8\u75b9wheals)\uff0c\u53ef\u80fd\u5168\u8eab\u5230\u8655\u8dd1\uff0c\u7279\u8272\u300c\u4f86\u5f97\u5feb\u3001\u6d88\u5f97\u4e5f\u5feb\u300d\uff0c\u540c\u4e00\u8655\u901a\u5e38\u5728 24 \u5c0f\u6642\u5167\u5c31\u6703\u6d88\u9000\u4e14\u4e0d\u7559\u75d5\u8de1\u3002\u82e5\u53cd\u8986\u767c\u4f5c\u8d85\u904e\uff16\u9031\uff0c\u5c31\u7a31\u70ba\u6162\u6027\u8541\u9ebb\u75b9\u3002<\/p>\n\n\n\n

\u3000\u3000\u6162\u6027\u8541\u9ebb\u75b9\u53ef\u4f9d\u6709\u7121\u660e\u78ba\u5916\u5728\u8a98\u56e0\u5206\u70ba\u5169\u5927\u985e\u3002\u82e5\u767c\u4f5c\u8207\u51b7\u3001\u71b1\u3001\u58d3\u529b\u3001\u65e5\u66ec\u6216\u904b\u52d5\u7b49\u7279\u5b9a\u523a\u6fc0\u6709\u95dc\uff0c\u5247\u7a31\u70ba\u6162\u6027\u8a98\u767c\u6027\u8541\u9ebb\u75b9\uff08CindU : chronic inducible urticaria ) \uff1b\u82e5\u6c92\u6709\u660e\u78ba\u5916\u5728\u539f\u56e0\uff0c\u75c7\u72c0\u537b\u53cd\u8986\u81ea\u884c\u767c\u4f5c\uff0c\u5c31\u7a31\u70ba\u6162\u6027\u81ea\u767c\u6027\u8541\u9ebb\u75b9(CSU\uff1achronicspontaneous urticaria)\u3002\u904e\u53bb\u9762\u5c0d\u6162\u6027\u81ea\u767c\u6027\u8541\u9ebb\u75b9\uff0c\u60a3\u8005\u6700\u5e38\u554f\uff1a\u300c\u70ba\u4ec0\u9ebc\u6211\u6703\u5f97\u8541\u9ebb\u75b9\uff1f\u8541\u9ebb\u75b9\u662f\u4ec0\u9ebc\u539f\u56e0\uff1f\uff08\u6c92\u6709\u539f\u56e0\uff0c\u81ea\u767c\u6027\uff0c\u83ab\u540d\u5176\u5999\u767c\u4f5c\uff09\uff1f\u300d\u300c\u70ba\u4ec0\u9ebc\u4ee5\u524d\u6211\u90fd\u4e0d\u6703\u8541\u9ebb\u75b9\uff1f\u6211\u7684\u8541\u9ebb\u75b9\u662f\u4e0d\u662f\u4e00\u8f29\u5b50\u90fd\u4e0d\u6703\u597d\u4e86\uff1f\u300d\u4ee5\u524d\u9019\u4e9b\u554f\u984c\u7684\u78ba\u4e0d\u597d\u56de\u7b54\uff0c\u4f46\u73fe\u5728\u6211\u5011\u5df2\u6709\u66f4\u6df1\u5165\u7684\u77ad\u89e3\uff0c\u6162\u6027\u8541\u9ebb\u75b9\u4e26\u4e0d\u53ea\u662f\u55ae\u7d14\u7684\u300c\u904e\u654f\u300d\uff0c\u800c\u662f\u4e00\u7a2e\u80a5\u5927\u7d30\u80de\u9a45\u52d5\u75be\u75c5(mast cell-driven disease )\u3002\u7576\u80a5\u5927\u7d30\u80de\u8207\u55dc\u9e7c\u6027\u7403\u88ab\u6d3b\u5316\u4e26\u53bb\u9846\u7c92\uff0c\u91cb\u653ehistamine\u3001tryptase\u3001leukotrienes\u3001prostaglandins\u53ca\u591a\u7a2e\u7d30\u80de\u6fc0\u7d20\uff0c\u9032\u800c\u9020\u6210\u6414\u7662\u3001\u98a8\u75b9\u584a\u8207\u8840\u7ba1\u6027\u6c34\u816b\u3002\u50b3\u7d71\u6cbb\u7642\u4e3b\u8981\u963b\u65b7\u6297\u7d44\u7e54\u80fa\u6240\u9020\u6210\u7684\u75c7\u72c0\uff1b\u73fe\u5728\u5247\u9010\u6f38\u671d\u5411\u66f4\u4e0a\u6e38\u7684\u95dc\u9375\u514d\u75ab\u8def\u5f91\u767c\u5c55\uff0c\u6291\u5236\u80a5\u5927\u7d30\u80de\u6d3b\u5316\u95dc\u9375\u514d\u75ab\u53cd\u61c9(\u5716\u4e00)\u3002<\/p>\n\n\n

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\"\"
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\u6162\u6027\u8541\u9ebb\u75b9\uff1a\u5f9e\u50b3\u7d71\u75c7\u72c0\u63a7\u5236\uff0c\u8d70\u5411\u8f03\u7cbe\u6e96\u85e5\u7269\u6cbb\u7642<\/strong><\/p>\n\n\n\n

\u3000\u3000\u4ecb\u7d39\u6162\u6027\u81ea\u767c\u6027\u8541\u9ebb\u75b9\u7684\u4e09\u7a2e\u9032\u968e\u6cbb\u7642\u85e5\u7269\u3002Omalizumab \u70ba\u6297 IgE \u55ae\u682a\u6297\u9ad4\uff0c\u53ef\u964d\u4f4e IgE\u2013Fc\u03b5RI \u76f8\u95dc\u7684\u80a5\u5927\u7d30\u80de\u6d3b\u5316\u3002\u675c\u907f\u708e Dupilumab \u5247\u4f5c\u7528\u65bcIL-4R\u03b1\uff0c\u963b\u65b7IL-4\u8207IL-13\u7b2c\u4e8c\u578b\u767c\u708e\u53cd\u61c9\u3002Remibrutinib \u5247\u662f\u53e3\u670d BTK \u6291\u5236\u5291\uff0c\u53ef\u6291\u5236\u7d30\u80de\u5167BTK\u8a0a\u865f\uff0c\u964d\u4f4e\u80a5\u5927\u7d30\u80de\u8207\u55dc\u9e7c\u6027\u7403\u6d3b\u5316\uff0cRemibrutinib\u7684\u7279\u8272\u5728\u65bc\u53e3\u670d\u7d66\u85e5\u8207\u5feb\u901f\u8d77\u6548\u3002REMIX-1\u8207REMIX-2\u7b2c\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u986f\u793a\uff0c\u6297\u7d44\u7e54\u80fa\u6cbb\u7642\u5f8c\u4ecd\u6709\u75c7\u72c0\u7684\u60a3\u8005\uff0c\u5728\u6cbb\u7642\u65e9\u671f\u5373\u53ef\u89c0\u5bdf\u5230\u6539\u5584\uff0c\u4e26\u96a8\u6301\u7e8c\u6cbb\u7642\u9032\u4e00\u6b65\u63d0\u5347\u75be\u75c5\u63a7\u5236\u7a0b\u5ea6\uff08\u8acb\u898b\u8868\u4e00\uff09\u3002<\/p>\n\n\n

\n
\"\"
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\u7d50\u8a9e\uff1a<\/strong><\/p>\n\n\n\n

\u3000\u3000\u6211\u5011\u5c0d\u6162\u6027\u81ea\u767c\u6027\u8541\u9ebb\u75b9\u5df2\u7d93\u6bd4\u4ee5\u5f80\u77ad\u89e3\u4e86\u66f4\u591a\uff0c\u6cbb\u7642\u4e5f\u4e0d\u518d\u55ae\u55ae\u53ea\u300c\u628a\u7662\u58d3\u4e0b\u4f86\u300d\u3002\u96a8\u8457 IgE\u3001IL-4\/IL-13\u3001BTK \u7814\u7a76\u3001\u4ee5\u53ca\u672a\u4f86anti-c-KIT\u3001anti-TSLP\u7b49\u65b0\u6cbb\u7642\u6301\u7e8c\u767c\u5c55\uff0c\u6211\u5011\u5c07\u6709\u66f4\u591a\u4e0d\u540c\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u76f8\u4fe1\u61c9\u53ef\u4ee5\u4f9d\u7167\u6bcf\u4f4d\u60a3\u8005\u7684\u72c0\u6cc1\u627e\u5230\u66f4\u9069\u5408\u7684\u6cbb\u7642\u65b9\u5f0f\u3002<\/p>\n\n\n\n

References<\/p>\n\n\n\n

    \n
  1. JAMA. 2024 Nov 5;332(17):1464-1477.<\/li>\n\n\n\n
  2. J Allergy Clin Immunol. 2016 Feb;137(2):474-81.<\/li>\n\n\n\n
  3. N Engl J Med. 2022 Sep 1;387(9):824-831.<\/li>\n\n\n\n
  4. N Engl J Med. 2013 Mar 7;368(10):924-35.<\/li>\n\n\n\n
  5. JAMA Dermatol. 2026 Apr 1;162(4):350-358.<\/li>\n\n\n\n
  6. Food and Drug Administration. Updated date: 2026-04-22.<\/li>\n\n\n\n
  7. J Allergy Clin Immunol. 2026 Jan;157(1):143-154.<\/li>\n\n\n\n
  8. N Engl J Med. 2025 Mar 6;392(10):984-994.<\/li>\n\n\n\n
  9. Food and Drug Administration. Updated date: 2026-03-23.<\/li>\n\n\n\n
  10. Presented at the European Academy of Dermatology & Venereology(EADV) Conference, Amsterdam, The Netherlands, September 25, 2024 .<\/li>\n\n\n\n
  11. J Allergy Clin Immunol. 2024 Jul;154(1):184-194.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u6587\/\u76ae\u819a\u79d1 \u856d\u7389\u5c4f\u6559\u6388 \u3000\u3000\u8541\u9ebb\u75b9\u662f\u4e00\u7a2e\u5e38\u898b\u7684\u76ae\u819a\u75be\u75c5\uff0c\u5e38\u5e38\u662f\u7a81\u7136\u5f88\u7662\uff0c\u63a5\u8457\u51fa\u73fe\u50cf\u868a\u5b50\u54ac\u4e00\u6a23\uff0c\u4e00\u584a\u4e00\u584a\u816b\u8d77\u4f86\u7684 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[385,852,519,602,255],"class_list":["post-6411","post","type-post","status-publish","format-standard","hentry","category-19","tag-385","tag-852","tag-519","tag-602","tag-255"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts\/6411"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6411"}],"version-history":[{"count":1,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts\/6411\/revisions"}],"predecessor-version":[{"id":6415,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts\/6411\/revisions\/6415"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6411"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6411"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6411"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}