{"id":5652,"date":"2024-06-04T10:41:42","date_gmt":"2024-06-04T02:41:42","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/cshmagazine\/?p=5652"},"modified":"2024-06-04T10:41:44","modified_gmt":"2024-06-04T02:41:44","slug":"%e3%80%8e%e7%97%9b%e9%a2%a8%e8%88%87%e5%b0%bf%e9%85%b8%e3%80%8f%e8%97%a5%e7%89%a9%e6%b2%bb%e7%99%82%e6%96%b0%e9%80%b2%e5%b1%95","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/?p=5652","title":{"rendered":"\u300e\u75db\u98a8\u8207\u5c3f\u9178\u300f\u85e5\u7269\u6cbb\u7642\u65b0\u9032\u5c55"},"content":{"rendered":"\n<p style=\"text-align:right\">\u6587\/\u904e\u654f\u514d\u75ab\u98a8\u8a3a\u6fd5\u79d1\u3000\u9b4f\u6b63\u5b97 \u526f\u9662\u9577<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/web.csh.org.tw\/web\/cshmagazine\/wp-content\/uploads\/2024\/06\/11306-03.jpg\" alt=\"\" class=\"wp-image-5653\" width=\"268\" height=\"358\"\/><\/figure><\/div>\n\n\n\n<p>\u3000\u3000\u75db\u98a8\u662f\u4e00\u7a2e\u56e0\u5c3f\u9178\u9e7d\u7d50\u6676\u6c89\u7a4d\u5728\u95dc\u7bc0\u548c\u5176\u4ed6\u7d44\u7e54\u4e2d\u800c\u5f15\u8d77\u7684\u95dc\u7bc0\u708e\u75be\u75c5\uff0c\u8868\u73fe\u70ba\u7a81\u767c\u6027\u95dc\u7bc0\u708e\u75c7\uff0c\u4f34\u96a8\u8457\u5287\u70c8\u75bc\u75db\u3002\u8fd1\u5e74\u4f86\uff0c\u5c0d\u65bc\u75db\u98a8\u548c\u9ad8\u5c3f\u9178\u8840\u75c7\u7684\u6cbb\u7642\u7814\u7a76\u53d6\u5f97\u4e86\u65b0\u7684\u9032\u5c55\uff0c\u65b0\u7684\u6cbb\u7642\u7b56\u7565\u548c\u85e5\u7269\u6301\u7e8c\u88ab\u958b\u767c\u548c\u8a55\u4f30\uff0c\u4ee5\u6539\u5584\u75db\u98a8\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u91cf\u4e26\u6e1b\u5c11\u75be\u75c5\u5fa9\u767c\u3002<\/p>\n\n\n\n<p><strong>\u5408\u7406\u7684\u98f2\u98df\u8abf\u6574<\/strong><\/p>\n\n\n\n<p>\u3000\u3000\u98df\u7269\u8207\u5c3f\u9178\u6c34\u5e73\u4e4b\u9593\u7684\u95dc\u4fc2\u662f\u75db\u98a8\u548c\u9ad8\u5c3f\u9178\u8840\u75c7\u7ba1\u7406\u7684\u91cd\u8981\u8003\u616e\u56e0\u7d20\u3002\u5c3f\u9178\u662f\u560c\u5464\u4ee3\u8b1d\u7684\u6700\u7d42\u7522\u7269\uff0c\u5728\u67d0\u4e9b\u98df\u7269\u4e2d\u560c\u5464\u542b\u91cf\u8f03\u9ad8\uff0c\u651d\u53d6\u904e\u91cf\u53ef\u80fd\u5c0e\u81f4\u8840\u5c3f\u9178\u6c34\u5e73\u5347\u9ad8\uff0c\u589e\u52a0\u75db\u98a8\u767c\u4f5c\u7684\u98a8\u96aa\u3002<\/p>\n\n\n\n<p><strong>\u61c9\u8a72\u907f\u514d\u7684\u98df\u7269<\/strong><\/p>\n\n\n\n<p>\u3000\u3000\u4e00\u4e9b\u98df\u7269\u56e0\u9ad8\u560c\u5464\u542b\u91cf\u800c\u88ab\u8a8d\u70ba\u53ef\u80fd\u589e\u52a0\u8840\u5c3f\u9178\u6c34\u5e73\u548c\u75db\u98a8\u767c\u4f5c\u98a8\u96aa\uff0c\u5305\u62ec\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>\u5167\u81df\u548c\u8089\u985e\uff1a\u5982\u725b\u8089\u3001\u7f8a\u8089\u548c\u52a0\u5de5\u8089\u985e\u3002<\/li><li>\u6d77\u9bae\uff1a\u7279\u5225\u662f\u9ad8\u560c\u5464\u6d77\u9bae\uff0c\u5982\u8766\u3001\u87f9\u548c\u67d0\u4e9b\u9b5a\u985e\uff08\u6c99\u4e01\u9b5a\u548c\u9be1\u9b5a\uff09\u3002<\/li><li>\u9152\u7cbe\uff1a\u5c24\u5176\u5564\u9152\u548c\u70c8\u9152\uff0c\u53ef\u986f\u8457\u589e\u52a0\u5c3f\u9178\u6c34\u5e73\u4e26\u8a98\u767c\u75db\u98a8\u767c\u4f5c\u3002<\/li><li>\u542b\u7cd6\u98f2\u6599\u548c\u679c\u6c41\uff1a\u5bcc\u542b\u679c\u7cd6\u7684\u98f2\u6599\u53ef\u80fd\u589e\u52a0\u5c3f\u9178\u751f\u6210\u3002<\/li><\/ul>\n\n\n\n<p><strong>\u53ef\u4ee5\u591a\u5403\u7684\u98df\u7269<\/strong><\/p>\n\n\n\n<p>\u3000\u3000\u5efa\u8b70\u75db\u98a8\u60a3\u8005\u548c\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u63a1\u7528\u4f4e\u560c\u5464\u98f2\u98df\uff0c\u5305\u62ec\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>\u6c34\u679c\u548c\u852c\u83dc\uff1a\u5927\u90e8\u5206\u6c34\u679c\u3001\u852c\u83dc\u548c\u5168\u7a40\u7269\u7684\u560c\u5464\u542b\u91cf\u4f4e\uff0c\u53ef\u4f5c\u70ba\u98f2\u98df\u7684\u4e3b\u8981\u90e8\u5206\u3002<\/li><li>\u4e73\u88fd\u54c1\uff1a\u4f4e\u8102\u4e73\u88fd\u54c1\u88ab\u8a8d\u70ba\u6709\u52a9\u65bc\u964d\u4f4e\u5c3f\u9178\u6c34\u5e73\u3002<\/li><li>\u98f2\u6c34\uff1a\u589e\u52a0\u6c34\u651d\u5165\u6709\u52a9\u65bc\u4fc3\u9032\u5c3f\u9178\u6392\u6cc4\u3002<\/li><\/ul>\n\n\n\n<p><strong>\u6a19\u6e96\u85e5\u7269\u6cbb\u7642\u56de\u9867<\/strong><\/p>\n\n\n\n<p>\u3000\u3000\u75db\u98a8\u6cbb\u7642\u6a19\u6e96\u7b56\u7565\u4e3b\u8981\u96c6\u4e2d\u5169\u500b\u65b9\u9762\uff1a\u7de9\u89e3\u6025\u6027\u767c\u4f5c\u75bc\u75db\u548c\u708e\u75c7\u53ca\u9577\u671f\u7ba1\u7406\u964d\u4f4e\u5c3f\u9178\u6c34\u5e73\uff0c\u9632\u6b62\u7d50\u6676\u6c89\u7a4d\u548c\u75be\u75c5\u5fa9\u767c\u3002\u975e\u985e\u56fa\u9187\u6297\u708e\u85e5\uff08NSAIDs\uff09\u3001\u79cb\u6c34\u4ed9\u7d20\uff08C o l c h i c i n e\uff09\u548c\u7cd6\u76ae\u8cea\u6fc0\u7d20\ufe59Glucocorticoid\ufe5a\u63a7\u5236\u6025\u6027\u75db\u98a8\u767c\u4f5c\u5e38\u7528\u85e5\u7269\u3002\u964d\u5c3f\u9178\u85e5\u7269\uff0c \u5982\u5225\u560c\u5464\u9187\ufe59Allopurinol\ufe5a\uff0cBenzbromarone\uff08\u674f\u5b9a\u75db\uff09\u548cFebuxostat\uff08\u798f\u907f\u75db\uff09\uff0c\u7528\u65bc\u9577\u671f\u7ba1\u7406\uff0c\u7dad\u6301\u8840\u6db2\u4e2d\u5c3f\u9178\u6c34\u5e73\u5728\u6b63\u5e38\u7bc4\u570d\u5167\u3002\u9019\u4e9b\u85e5\u7269\u53ef\u4ee5\u5e6b\u52a9\u6211\u5011\u4fdd\u6301\u8840\u4e2d\u5c3f\u9178\u6fc3\u5ea6\u5728\u7406\u60f3\u7bc4\u570d\uff0c\u5927\u6982\u662f\u6bcf\u5206\u53474\u52306\u6beb\u514b\u3002<\/p>\n\n\n\n<p><strong>\u65b0\u6cbb\u7642\u9032\u5c55<\/strong><\/p>\n\n\n\n<p>\u3000\u3000\u8fd1\u5e74\u4f86\uff0c\u95dc\u65bc\u75db\u98a8\u6cbb\u7642\u7684\u7814\u7a76\u4e3b\u8981\u805a\u7126\u65bc\u958b\u767c\u65b0\u7684\u85e5\u7269\u548c\u6cbb\u7642\u7b56\u7565\uff0c\u4ee5\u89e3\u6c7a\u6a19\u6e96\u6cbb\u7642\u7684\u4e0d\u8db3\u548c\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7642\u9ad4\u9a57\u3002<\/p>\n\n\n\n<p><strong>Febuxostat\n<\/strong><strong>\ufe59\u798f\u907f\u75db\ufe5a<\/strong><\/p>\n\n\n\n<p>\u3000\u3000\u7528\u65bc\u6cbb\u7642\u9ad8\u5c3f\u9178\u8840\u75c7\u548c\u75db\u98a8\u7684\u85e5\u7269\uff0c\u5176\u4f5c\u7528\u6a5f\u5236\u662f\u4f5c\u70ba\u4e00\u7a2e\u9078\u64c7\u6027\u9ec3\u560c\u5464\u6c27\u5316\u9176\uff08XO\uff09\u6291\u5236\u5291\u3002\u9ec3\u560c\u5464\u6c27\u5316\u9176\u662f\u560c\u5464\u4ee3\u8b1d\u8def\u5f91\u4e2d\u7684\u95dc\u9375\u9176\uff0c\u8ca0\u8cac\u5c07\u560c\u5464\u8f49\u5316\u70ba\u5c3f\u9178\u3002Febuxostat\n\u901a\u904e\u6291\u5236\u6b64\u9176\uff0c\u5f9e\u800c\u6e1b\u5c11\u5c3f\u9178\u751f\u6210\uff0c\u6709\u52a9\u65bc\u964d\u4f4e\u8840\u6db2\u4e2d\u5c3f\u9178\u6c34\u5e73\uff0c\u4e26\u6e1b\u5c11\u8207\u75db\u98a8\u76f8\u95dc\u7684\u75db\u98a8\u77f3\u548c\u6025\u6027\u75db\u98a8\u767c\u4f5c\u7684\u98a8\u96aa\u3002<\/p>\n\n\n\n<p>\u3000\u3000Febuxostat\u5728\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\u4e2d\u986f\u793a\u51fa\u826f\u597d\u7684\u7642\u6548\uff0c\u80fd\u5920\u6709\u6548\u5730\u964d\u4f4e\u60a3\u8005\u8840\u5c3f\u9178\u6c34\u5e73\u81f3\u76ee\u6a19\u7bc4\u570d\u3002\u4f8b\u5982\uff0c\u5728\u4e00\u500b\u88ab\u7a31\u70baFACT\u8a66\u9a57\u7684\u7814\u7a76\u4e2d\uff0c\u8207\u6cbb\u7642\u6a19\u6e96\u7684\u5225\u560c\u5464\u9187\u76f8\u6bd4\uff0c\u66f4\u591a\u670d\u7528Febuxostat\u7684\u60a3\u8005\u80fd\u5c07\u4ed6\u5011\u7684\u8840\u5c3f\u9178\u6c34\u5e73\u964d\u81f36.0\u4ee5\u4e0b\u3002\u9019\u9805\u7814\u7a76\u767c\u8868\u5728\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u671f\u520a\u4e0a\u3002Febuxostat\u4e00\u822c\u4f86\u8aaa\u662f\u5b89\u5168\u7684\u3002\u4f46\u5c31\u50cf\u8a31\u591a\u85e5\u7269\u4e00\u6a23\uff0c\u5b83\u53ef\u80fd\u6703\u6709\u526f\u4f5c\u7528\u3002\u6709\u4e9b\u7814\u7a76\u6307\u51fa\uff0c\u670d\u7528Febuxostat\u7684\u75db\u98a8\u60a3\u8005\u53ef\u80fd\u6703\u6709\u8f03\u9ad8\u7684\u5fc3\u81df\u554f\u984c\u98a8\u96aa\uff0c\u7279\u5225\u662f\u5c0d\u90a3\u4e9b\u5df2\u7d93\u6709\u5fc3\u81df\u75be\u75c5\u7684\u4eba\u4f86\u8aaa\u3002\u8209\u4f8b\u4f86\u8aaa\uff0c\u6709\u4e00\u9805\u53eb\u505aCARES\u7684\u7814\u7a76\u5c08\u9580\u6bd4\u8f03\u4e86\u5fc3\u81df\u75c5\u60a3\u8005\u670d\u7528Febuxostat\u548c\u53e6\u4e00\u7a2e\u85e5\u7269\u5225\u560c\u5464\u9187\u7684\u5b89\u5168\u6027\uff0c\u767c\u73feFebuxostat\u7684\u7528\u6236\u6b7b\u65bc\u5fc3\u81df\u75c5\u7684\u6a5f\u7387\u4f3c\u4e4e\u7a0d\u9ad8\u4e00\u4e9b\u3002\u91ab\u751f\u6703\u5728\u958bFebuxostat\u4e4b\u524d\u5148\u7d9c\u5408\u8003\u616e\u75c5\u4eba\u7684\u6574\u9ad4\u5065\u5eb7\u60c5\u6cc1\u548c\u5fc3\u81df\u75c5\u98a8\u96aa\uff0c\u4e26\u4e14\u6703\u8ddf\u75c5\u4eba\u8a0e\u8ad6\u9019\u7a2e\u85e5\u7269\u53ef\u80fd\u5e36\u4f86\u7684\u98a8\u96aa\u548c\u9810\u671f\u7684\u597d\u8655\u3002\u5982\u679c\u75c5\u4eba\u6709\u5fc3\u81df\u75be\u75c5\u7684\u75c5\u53f2\uff0c\u91ab\u751f\u53ef\u80fd\u6703\u8003\u616e\u7528\u5225\u7684\u85e5\u7269\u6cbb\u7642\uff0c\u6216\u8005\u66f4\u5bc6\u5207\u5730\u76e3\u63a7\u75c5\u4eba\u7684\u5065\u5eb7\u72c0\u6cc1\u3002<\/p>\n\n\n\n<p><strong>Tigulixostat\n<\/strong><strong>\ufe59UR-1102\ufe5a<\/strong><\/p>\n\n\n\n<p>\u3000\u3000\u4e5f\u7a31\u70baUR-1102\uff0c\u662f\u4e00\u7a2e\u65b0\u578b\u9078\u64c7\u6027\u5c3f\u9178\u751f\u6210\u6291\u5236\u5291\uff0c\u985e\u4f3c\u65bc\u5225\u560c\u5464\u9187\u548c\u8cbb\u5e03\u7d22\u5766\u3002\u5b83\u901a\u904e\u6291\u5236\u9ec3\u560c\u5464\u6c27\u5316\u9176\uff08XO\uff09\uff0c\u9019\u662f\u5c3f\u9178\u751f\u6210\u904e\u7a0b\u4e2d\u7684\u95dc\u9375\u9176\u3002Tigulixostat\u53ef\u80fd\u5177\u6709\u6539\u9032\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u6027\u548c\u66f4\u512a\u7684\u5b89\u5168\u6027\u5256\u9762\uff0c\u5c24\u5176\u662f\u5728\u6709\u814e\u529f\u80fd\u4e0d\u5168\u7684\u75db\u98a8\u60a3\u8005\u4e2d\u3002\u9019\u7a2e\u85e5\u7269\u53ef\u80fd\u5c0d\u65bc\u90a3\u4e9b\u4e0d\u80fd\u8010\u53d7\u6216\u5c0d\u5176\u4ed6\u6cbb\u7642\u7121\u53cd\u61c9\u7684\u60a3\u8005\u7279\u5225\u6709\u7528\u3002\u76ee\u524d\uff0c\u9019\u500b\u65b0\u85e5\u6b63\u5728\u9032\u884c\u8de8\u570b\u7b2c\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u7576\u4e2d\uff0c\u4e2d\u5c71\u91ab\u5b78\u5927\u5b78\u9644\u8a2d\u91ab\u9662\u4e5f\u53c3\u8207\u9019\u9805\u7814\u7a76\u3002<\/p>\n\n\n\n<p>\u3000\u3000\u91dd\u5c0d\u5c3f\u9178\u8f49\u904b\u86cb\u767d1\uff08URAT1\uff09\u65b0\u85e5\u7269\u958b\u767c\u662f\u75db\u98a8\u6cbb\u7642\u7814\u7a76\u4e2d\u4e00\u500b\u91cd\u8981\u65b9\u5411\u3002URAT1\u662f\u814e\u81df\u4e2d\u8ca0\u8cac\u5c3f\u9178\u91cd\u5438\u6536\u4e3b\u8981\u8f49\u904b\u86cb\u767d\uff0c\u6291\u5236URAT1\u53ef\u4ee5\u589e\u52a0\u5c3f\u9178\u7684\u6392\u6cc4\uff0c\u964d\u4f4e\u8840\u5c3f\u9178\u6c34\u5e73\uff0c\u5c0d\u75db\u98a8\u6cbb\u7642\u5177\u6709\u91cd\u8981\u610f\u7fa9\u3002\u8fd1\u5e74\u4f86\uff0c\u5e7e\u7a2e\u65b0URAT1\u6291\u5236\u5291\u5df2\u7d93\u88ab\u7814\u767c\u548c\u8a55\u4f30\uff0c\u986f\u793a\u51fa\u6cbb\u7642\u75db\u98a8\u7684\u6f5b\u529b\u3002<\/p>\n\n\n\n<p><strong>Dotinurad<\/strong><\/p>\n\n\n\n<p>\u3000\u3000\u9019\u662f\u65e5\u672c\u5df2\u7d93\u4e0a\u5e02\u7684\u85e5\u7269\uff0c\u4f46\u53f0\u7063\u76ee\u524d\u9084\u6c92\u6709\u5f15\u9032\u3002\u5728\u7814\u7a76\u4e2d\uff0c300\u540d\u75db\u98a8\u75c5\u4eba\u53c3\u8207\u4e86\u4e00\u500b\u7279\u5225\u7684\u8a66\u9a57\uff0c 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