{"id":5367,"date":"2023-10-03T16:16:24","date_gmt":"2023-10-03T08:16:24","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/cshmagazine\/?p=5367"},"modified":"2023-10-03T16:16:26","modified_gmt":"2023-10-03T08:16:26","slug":"%e7%87%9f%e9%a4%8a%e8%88%87%e9%80%80%e5%8c%96%e6%80%a7%e9%97%9c%e7%af%80%e7%82%8e","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/?p=5367","title":{"rendered":"\u71df\u990a\u8207\u9000\u5316\u6027\u95dc\u7bc0\u708e"},"content":{"rendered":"\n
\"\"<\/figure><\/div>\n\n\n\n

\u6587\/\u71df\u990a\u79d1 \u5f90\u6b3d\u9d6c \u7d44\u9577<\/p>\n\n\n\n

\u3000\u3000\u9000\u5316\u6027\u95dc\u7bc0\u708e\u53c8\u7a31\u9aa8\u95dc\u7bc0\u708e(Osteoarthritis,OA)\uff0c\u70ba\u5168\u7403\u5e38\u898b\u7684\u95dc\u7bc0\u708e\u4e4b\u4e00\uff0c\u56b4\u91cd\u6642\u6703\u5f15\u8d77\u95dc\u7bc0\u75bc\u75db\u3001\u816b\u8139\u8207\u7dca\u7e43\u50f5\u786c\u7b49\u4e0d\u9069\u75c7\u72c0\u3002\u6839\u64da108\u5e74\u885b\u751f\u798f\u5229\u90e8\u7d71\u8a08\u81fa\u7063OA\u76db\u884c\u7387\u7d0415%\uff0c\u5176\u4e2d70\u6b72\u4ee5\u4e0a\u9577\u8005\u66f4\u903e70 %\u7f79\u6709OA\uff0c\u591a\u6578\u7814\u7a76\u767c\u73fe\u5973\u6027\u767c\u751f\u7387\u660e\u986f\u8f03\u7537\u6027\u70ba\u9ad8\uff0c\u800c\u8001\u5316\u3001\u80a5\u80d6\u3001\u95dc\u7bc0\u640d\u50b7\u8207\u9577\u671f\u53d7\u58d3\u3001\u907a\u50b3\u6216\u7cd6\u5c3f\u75c5\u7b49\u4ee3\u8b1d\u6027\u75be\u75c5\u7686\u70ba\u5f15\u8d77OA\u7684\u98a8\u96aa\u56e0\u5b50\uff0c\u4f46OA\u8fc4\u4eca\u50c5\u80fd\u63a1\u53d6\u75c7\u72c0\u7de9\u89e3\u3001\u4f7f\u7528\u8b77\u5177\u7b49\u4fdd\u5b88\u6cbb\u7642\uff0c\u82e5\u5c0d\u75c5\u4eba\u7684\u6d3b\u52d5\u5f71\u97ff\u751a\u9245\u6642\u751a\u81f3\u9700\u8003\u616e\u4eba\u5de5\u95dc\u7bc0\u7f6e\u63db\u8853\u3002<\/p>\n\n\n\n

\u3000\u3000\u9664\u4e86\u524d\u8ff0\u5e38\u898f\u6cbb\u7642\u5916\uff0c\u98f2\u98df\u8207\u751f\u6d3b\u4ea6\u88ab\u8a8d\u70ba\u80fd\u6539\u5584OA\u5f15\u8d77\u7684\u4e0d\u9069\u75c7\u72c0\uff0c\u4e00\u7bc7\u56de\u9867\u5f0f\u7814\u7a76\u6307\u51fa\u4ee5\u4e0b\u53ef\u80fd\u5f71\u97ffOA\u4e4b\u751f\u6d3b\u8207\u98f2\u98df\u578b\u614b[1]\uff1a<\/p>\n\n\n\n

  1. \u9ad4\u91cd\u7ba1\u7406\uff1a\u80a5\u80d6\u8005\u6709\u66f4\u9ad8\u63a5\u53d7\u95dc\u7bc0\u7f6e\u63db\u8853\u7684\u98a8\u96aa\uff0c\u800c\u80a5\u80d6\u5c07\u5c0e\u81f4\u9ad4\u5167\u6162\u6027\u767c\u708e\uff0c\u4e26\u900f\u904e\u767d\u8272\u8102\u80aa\u589e\u52a0\u7626\u7d20(Leptin)\u751f\u6210\uff0c\u80a5\u80d6\u8005\u9ad4\u5167\u7684\u9ad8\u7626\u7d20\u91cf\u88ab\u8a8d\u70ba\u5c07\u4fc3\u9032\u708e\u75c7\u9032\u800c\u640d\u50b7\u8edf\u9aa8\uff0c\u4e14\u80a5\u80d6\u4ea6\u6703\u4fc3\u9032\u4ee3\u8b1d\u75c7\u5019\u7fa4\u8207\u7f79\u60a3\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u98a8\u96aa\uff0c\u9ad8\u8840\u7cd6\u6240\u5f62\u6210\u7684\u7cd6\u5316\u7d42\u7522\u7269(advanced glycation end products, AGEs)\u6c89\u7a4d\u65bc\u95dc\u7bc0\u4ea6\u6703\u9020\u6210\u8edf\u9aa8\u50b7\u5bb3\uff0c\u5fb7\u570b\u7814\u7a76\u6307\u51fa\u9ad8\u8840\u7cd6\u53ef\u4ee5\u4f5c\u70ba\u9810\u6e2cOA\u75c5\u4eba\u672a\u4f86\u63a5\u53d7\u95dc\u7bc0\u7f6e\u63db\u8853\u7684\u7368\u7acb\u56e0\u5b50[2]\uff0c\u800c\u80a5\u80d6\u75c5\u4eba\u6e1b\u91cd\u81f3\u5c1110%\u53ef\u964d\u4f4e\u767c\u708e\u8207\u4ee3\u8b1d\u53cd\u61c9\u4e26\u6e1b\u7de9\u75bc\u75db\u3002<\/li>
  2. \u81b3\u98df\u8102\u80aa\uff1a\u8102\u80aa\u651d\u53d6\u5c0d\u65bc\u4eba\u9ad4\u5065\u5eb7\u7684\u5f71\u97ff\u5411\u4f86\u500d\u53d7\u95dc\u6ce8\u3002\u9ad4\u5167\u8f03\u9ad8\u7684\u03c9-6\u8102\u80aa\u9178\u5982\u82b1\u751f\u56db\u70ef\u9178(Arachidonic acid, AA)\u8207\u95dc\u7bc0\u767c\u751f\u6ed1\u819c\u708e(Synovitis)\u6709\u95dc\uff0c\u800c\u03c9-3\u8102\u80aa\u9178\u5247\u8207\u8edf\u9aa8\u8017\u640d\u5448\u8ca0\u76f8\u95dc\u3001\u4e26\u53ef\u964d\u4f4e\u767c\u708e\u53cd\u61c9[3]\u3002\u4f46\u90e8\u5206\u7814\u7a76\u767c\u73fe\u900f\u904e\u651d\u53d6\u9ad8\u5291\u91cf\u9b5a\u6cb9\u88dc\u5145\u03c9-3\u8102\u80aa\u9178\u5c0d\u6e1b\u7de9OA\u75c5\u4eba\u7684\u95dc\u7bc0\u75bc\u75db\u4f3c\u4e4e\u7121\u986f\u8457\u597d\u8655\uff0c\u5efa\u8b70\u5fc5\u8981\u6642\u9069\u5ea6\u88dc\u5145\u5373\u53ef\u3002\u65e5\u5e38\u70f9\u8abf\u53ef\u63a1\u7528\u5bcc\u542b\u03c9-9\u55ae\u5143\u4e0d\u98fd\u548c\u8102\u80aa\u9178\u7684\u6a44\u6b16\u6cb9\u3001\u83dc\u7c7d\u6cb9\u53d6\u4ee3\u03c9-6\u8102\u80aa\u9178\u542b\u91cf\u8f03\u9ad8\u7684\u5927\u8c46\u6cb9\u3001\u8475\u82b1\u6cb9\u7b49\uff0c\u4e26\u5145\u5206\u651d\u53d6\u5bcc\u542b\u8102\u80aa\u7684\u6cb9\u6027\u9b5a(oily fish)\uff0c\u5982\u9bd6\u9b5a\u3001\u9bad\u9b5a\u3001\u6c99\u4e01\u9b5a\u7b49\u4ee5\u88dc\u5145\u03c9-3\u8102\u80aa\u9178\u3002<\/li>
  3. \u81b3\u98df\u81bd\u56fa\u9187\uff1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u53ef\u80fd\u4fc3\u9032\u767c\u708e\u53cd\u61c9\u56e0\u800c\u589e\u52a0OA\u767c\u751f\u98a8\u96aa\uff0c\u4e14\u4fc3\u9032\u9ad4\u5167\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u5f62\u6210\uff0c\n\u53d7\u6c27\u5316\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d(Ox-LDL)\u53ef\u80fd\u53c3\u8207\u6ed1\u819c\u708e\u8207\u8edf\u9aa8\u7834\u58de\uff0c\u6545\u8840\u6e05\u81bd\u56fa\u9187\n> 200 mg\/dL\u6216\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d > 100mg\/dL\u8005\u5efa\u8b70\u5b9c\u63a7\u5236\u98fd\u548c\u8102\u80aa\u9178\u651d\u53d6\u91cf\u5c0f\u65bc\u6bcf\u65e5\u7e3d\u71b1\u91cf\u4e4b10%(\u7537\u6027\u7d0431g\/day\u3001\u5973\u6027\u7d0424g\/day)\u3001\u6bcf\u65e5\u81ea\u5404\u985e\u5929\u7136\u98df\u7269\u651d\u53d6\u690d\u7269\u56fa\u9187(Phytosterol)\u81f3\u5c112g\/day[4]\u3001\u651d\u53d6\u9ad8\u9ecf\u5ea6\u7e96\u7dad\u5982\u71d5\u9ea5\u3001\u4e9e\u9ebb\u7c7d\u7b49\u3001\u4e26\u9078\u7528\u5927\u8c46\u86cb\u767d\u8207\u5805\u679c\u985e\u98df\u7269\uff0c\u4e14\u4ecd\u5efa\u8b70\u80a5\u80d6\u8005\u61c9\u9069\u5ea6\u6e1b\u91cd\u3002<\/li>
  4. \u6297\u6c27\u5316\u7269\u8cea\uff1a\u90e8\u5206\u7814\u7a76\u767c\u73fe\uff0c\u6297\u6c27\u5316\u7dad\u751f\u7d20A\u3001C\u3001E\u6216\u8a31\u53ef\u964d\u4f4eOA\u5e36\u4f86\u7684\u75bc\u75db\uff0c\u6297\u6c27\u5316\u7269\u8cea\u53ef\u80fd\u53ef\u5ef6\u7de9\u9ad4\u5167\u81ea\u7531\u57fa\u5c0dOA\u7684\u5f71\u97ff\uff0c\u4e14\u7dad\u751f\u7d20C\u4ea6\u662f\u4fc3\u9032\u81a0\u539f\u86cb\u767d\u5f62\u6210\u7684\u95dc\u9375\uff0c\u96d6\u7136\u4ecd\u7121\u5145\u5206\u8b49\u64da\u8b49\u660e\u6297\u6c27\u5316\u7269\u8cea\u5c0d\u6539\u5584OA\u7684\u52a9\u76ca\uff0c\u4f46\u4ecd\u9f13\u52f5\u651d\u53d6\u8db3\u5920\u6297\u6c27\u5316\u7269\u8cea\u7dad\u6301\u5065\u5eb7\u3002<\/li>
  5. \u7dad\u751f\u7d20D\uff1a\u7dad\u751f\u7d20D\u53ef\u7dad\u6301\u9aa8\u4ee3\u8b1d\u3001\u9ad4\u5167\u9223\u6046\u5b9a\u8207\u6291\u5236\u767c\u708e\u53cd\u61c9\uff0c\u8fd1\u5e74\u66f4\u88ab\u8a8d\u70ba\u53ef\u7dad\u6301\u808c\u529b\uff0c\u5c0d\u6539\u5584OA\u75c7\u72c0\u5177\u6709\u6b63\u9762\u76ca\u8655\uff0c\u5efa\u8b70\u651d\u53d6\u5bcc\u542b\u7dad\u751f\u7d20D\u7684\u98df\u7269\u5982\u5404\u985e\u6cb9\u6027\u9b5a\u3001\u86cb\u9ec3\u3001\u725b\u5976\u8207\u83c7\u985e\uff0c\u6216\u5728\u672a\u64e6\u9632\u66ec\u4e73\u7684\u60c5\u6cc1\u4e0b\u6bcf\u65e5\u9069\u5ea6\u65e5\u66ec10~20\u5206\u9418\u4ee5\u4fc3\u9032\u9ad4\u5167\u5408\u6210\u7dad\u751f\u7d20D\u3002<\/li>
  6. \u7dad\u751f\u7d20K\uff1a\u7dad\u751f\u7d20K\u53ef\u5354\u540c\u9aa8\u9223\u7d20(Osteocalcin)\u5f37\u5316\u9aa8\u9abc\uff0c\u7814\u7a76\u767c\u73fe\u7f3a\u4e4f\u7dad\u751f\u7d20K\u8005\u53ef\u80fd\u6613\u5c0e\u81f4\u819d\u95dc\u7bc0\u534a\u6708\u8edf\u9aa8\u53d7\u640d\uff0c\u6545\u5efa\u8b70\u53ef\u589e\u52a0\u690d\u7269\u6027\u98df\u7269\uff0c\u5982\u7518\u85cd\u3001\u6df1\u7da0\u8272\u852c\u83dc\u6216\u690d\u7269\u6cb9\u7b49\u651d\u53d6\u7dad\u751f\u7d20K1\uff0c\u800c\u7dad\u751f\u7d20K2\u5247\u70ba\u8178\u9053\u7d30\u83cc\u5408\u6210\uff0c\u4ea6\u53ef\u900f\u904e\u52d5\u7269\u6027\u98df\u54c1\u5982\u96de\u86cb\u3001\u4e73\u88fd\u54c1\u3001\u8089\u985e\u8207\u767c\u9175\u98df\u54c1\u651d\u53d6\u3002<\/li><\/ol>\n\n\n\n

    \u3000\u3000\u96a8\u8457\u5e74\u9f61\u589e\u9577\uff0c\u8eab\u9ad4\u8001\u5316\u662f\u751f\u547d\u671f\u4e0d\u53ef\u907f\u514d\u7684\u6b77\u7a0b\uff0c\u4f46\u9020\u6210OA\u7684\u98a8\u96aa\u56e0\u5b50\u5982\u80a5\u80d6\u3001\u4e0d\u826f\u7684\u751f\u6d3b\u8207\u98f2\u98df\u7fd2\u6163\u7b49\u7686\u53ef\u900f\u904e\u65e5\u5e38\u7ba1\u7406\u4f86\u6539\u5584\uff0c\u5c24\u5176\u80a5\u80d6\u9020\u6210\u7684\u5065\u5eb7\u98a8\u96aa\u5df2\u70ba\u73fe\u4ee3\u4eba\u719f\u77e5\u3002\u96d6\u7136\u71df\u990a\u7d20\u5c0d\u65bcOA\u7684\u5f71\u97ff\u8207\u529f\u6548\u4ecd\u9700\u66f4\u591a\u7814\u7a76\u8b49\u5be6\uff0c\u4f46\u6bcf\u4e00\u7a2e\u98df\u7269\u90fd\u6709\u5176\u597d\u8655\uff0c\u5747\u8861\u651d\u53d6\u5404\u985e\u5929\u7136\u98df\u7269\u5373\u80fd\u5f9e\u4e2d\u7372\u5f97\u5404\u985e\u71df\u990a\uff0c\u4e0d\u61c9\u504f\u9817\u6392\u65a5\u7279\u5b9a\u98df\u7269\uff0c\u4ea6\u4e0d\u61c9\u904e\u5ea6\u4ef0\u8cf4\u5e02\u552e\u71df\u990a\u88dc\u5145\u54c1\uff0c\u9069\u5ea6\u6d3b\u52d5\u3001\u7dad\u6301\u826f\u597d\u5065\u5eb7\u751f\u6d3b\u578b\u614b\u5373\u662f\u9810\u9632\u53ca\u5ef6\u7de9\u5404\u985e\u75be\u75c5\u767c\u751f\u7684\u95dc\u9375\u3002<\/p>\n\n\n\n

    1. Thomas, S., Browne, H., Mobasheri, A., & Rayman, M.\nP. (2018).What is the evidence for a role for diet and nutrition\ninosteoarthritis?. Rheumatology, 57(suppl_4), iv61-iv74.<\/li>
    2. Schett, G., Kleyer, A., Perricone, C., et al.(2013).\nDiabetes is anindependent predictor for severe osteoarthritis: results from\nalongitudinal cohort study. Diabetes care, 36(2), 403-409.<\/li>
    3. Baker, K. R., Matthan, N. R., Lichtenstein, A. H., et\nal.(2012).Association of plasma n-6 and n-3 polyunsaturated fatty acidswith\nsynovitis in the knee: the MOST study. Osteoarthritis andcartilage, 20(5),\n382-387.<\/li>
    4. Katan, M. B., Grundy, S. M., Jones, P., et al.(2003).\nEfficacy andsafety of plant stanols and sterols in the management of\nbloodcholesterol levels. In Mayo Clinic Proceedings (Vol. 78, No. 8,\npp.965-978). Elsevier.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"

      \u6587\/\u71df\u990a\u79d1 \u5f90\u6b3d\u9d6c \u7d44\u9577 \u3000\u3000\u9000\u5316\u6027\u95dc\u7bc0\u708e\u53c8\u7a31\u9aa8\u95dc\u7bc0\u708e(Osteoarthritis,OA)\uff0c\u70ba\u5168\u7403\u5e38\u898b\u7684\u95dc\u7bc0 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[138,412,413,411],"class_list":["post-5367","post","type-post","status-publish","format-standard","hentry","category-21","tag-138","tag-412","tag-413","tag-411"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts\/5367"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5367"}],"version-history":[{"count":1,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts\/5367\/revisions"}],"predecessor-version":[{"id":5368,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts\/5367\/revisions\/5368"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5367"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5367"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}