{"id":4670,"date":"2022-03-01T17:16:44","date_gmt":"2022-03-01T09:16:44","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/cshmagazine\/?p=4670"},"modified":"2022-03-14T09:35:18","modified_gmt":"2022-03-14T01:35:18","slug":"%e4%b8%8d%e5%8f%aa%e6%98%af%e6%84%9f%e5%86%92%e7%9a%84-%e5%91%bc%e5%90%b8%e9%81%93%e8%9e%8d%e5%90%88%e7%97%85%e6%af%92","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/?p=4670","title":{"rendered":"\u4e0d\u53ea\u662f\u611f\u5192\u7684 \u547c\u5438\u9053\u878d\u5408\u75c5\u6bd2"},"content":{"rendered":"\n

\u85e5\u5291\u79d1 \u694a\u7ffc\u4e98 \u85e5\u5e2b<\/p>\n\n\n\n

\u3000\u3000\u547c\u5438\u9053\u878d\u5408\u75c5\u6bd2(Respiratory Syncytial Virus,\nRSV)\u662f\u4e00\u7a2eRNA\u75c5\u6bd2\uff0c\u548c\u816e\u817a\u708e\u75c5\u6bd2\u3001\u5fb7\u570b\u9ebb\u75b9\u75c5\u6bd2\u4e00\u6a23\u5c6c\u65bc\u526f\u9ecf\u6db2\u75c5\u6bd2\u79d1\n(paramyxoviridae)\u3002\u75c5\u6bd2\u5916\u5957\u819c\u8868\u9762\u6709 F\u86cb\u767d\u53ca G\u86cb\u767d\uff0cF\u86cb\u767d\u53c8\u7a31\u878d\u5408\u86cb\u767d(Fusion protein)\uff0c\u80fd\u4f7f\u75c5\u6bd2\u8207\u7d30\u80de\u878d\u5408\uff0c\u9020\u6210\u611f\u67d3\u6642\u7684\u767c\u708e\u53cd\u61c9\uff1bG\u86cb\u767d\u5247\u53ef\u5f15\u767c\u611f\u67d3\u5f8c\u7684\u514d\u75ab\u53cd\u61c9\u3002\u4eba\u985e\u70baRSV\u7684\u552f\u4e00\u5bbf\u4e3b\uff0c\u6240\u6709\u5e74\u9f61\u5c64\u7686\u53ef\u80fd\u611f\u67d3\uff0c\u60df\u75c7\u72c0\u4e0d\u56b4\u91cd\u3002\u5e7e\u4e4e\u6240\u6709\u4eba\u65bc2\u6b72\u524d\u90fd\u66fe\u611f\u67d3\u904e\uff0c\u4e14\u65bc\u4e4b\u5f8c\u4ea6\u80fd\u91cd\u8907\u611f\u67d3\u3002<\/p>\n\n\n\n

\u3000\u3000\u5176\u70ba\u5b30\u5e7c\u5152\u548c\u8001\u5e74\u4eba\u56b4\u91cd\u4e0b\u547c\u5438\u9053\u611f\u67d3\u7684\u91cd\u8981\u539f\u56e0\uff0c\u4ea6\u662f\u8001\u5e74\u4eba\u5e38\u898b\u7684\u611f\u67d3\u75c5\u6bd2\u4e2d\u50c5\u6b21\u65bc\u6d41\u611f\u7684\u75c5\u539f\u9ad4\u3002\u5c0d\u5b30\u5e7c\u5152\u7684\u5a01\u8105\u6700\u70ba\u660e\u986f\uff1b\u5728\u53f0\u7063\uff0c\u6bcf\u5e74\u7d04\u67091,000\u500b\u5b30\u5e7c\u5152\u56e0\u611f\u67d3\u547c\u5438\u9053\u878d\u5408\u75c5\u6bd2\u800c\u4f4f\u9662\uff0c\u9ad8\u9054\u4e5d\u6210\u70ba\u5169\u6b72\u4ee5\u4e0b\u7684\u5b30\u5e7c\u5152\uff0c\u56db\u5b63\u90fd\u53ef\u80fd\u767c\u751f\uff0c\u6625\u79cb\u5169\u5b63\u8f03\u986f\u8457\u3002\u75c5\u6bd2\u4fb5\u5165\u547c\u5438\u9053\u5f8c\u6f5b\u4f0f\u671f\u70ba2\u81f38\u5929\uff0c\u4ee54\u81f36\u5929\u6700\u5e38\u898b\u3002\u4f46\u5b30\u5e7c\u5152\u53ca\u514d\u75ab\u529b\u4f4e\u4e0b\u8005\u50b3\u67d3\u671f\u53ef\u9577\u90543\u81f34\u5468\u3002\u5927\u591a\u5728\u611f\u67d3\u5f8c\u7d041\u81f32\u5468\u75c7\u72c0\u6703\u81ea\u884c\u7de9\u89e3\u3002\u5b30\u5e7c\u5152\u53ca\u5b69\u7ae5\u611f\u67d3\u5f8c\u6240\u5e36\u4e4b\u75c5\u6bd2\u91cf\u53ca\u50b3\u67d3\u671f\u7686\u5927\u65bc\u6210\u4eba\u3002<\/p>\n\n\n\n

\u75c7\u72c0\u8207\u98a8\u96aa<\/strong><\/p>\n\n\n\n

\u3000\u3000\u611f\u67d3\u5f8c\u9020\u6210\u6c23\u7ba1\u4e0a\u76ae\u7d30\u80de\u58de\u6b7b\u3001\u9ecf\u6db2\u5206\u6ccc\u3001\u767c\u708e\u7d30\u80de\u6d78\u6f64\u7b49\u5c0e\u81f4\u7d30\u652f\u6c23\u7ba1\u6c23\u9053\u72f9\u7a84\uff0c\u6545\u5e7c\u5152\u6703\u6709\u660e\u986f\u7684\u5598\u9cf4\u8072\u8207\u56c9\u97f3\uff0c\u4e5f\u53ef\u80fd\u5408\u4f75\u98df\u617e\u4e0d\u4f73\u53ca\u812b\u6c34\u7684\u75c7\u72c0\uff1b\u56b4\u91cd\u6642\u6703\u9020\u6210\u80ba\u8449\u584c\u9677\uff0c\u9032\u4e00\u6b65\u5f15\u767c\u80ba\u708e\uff0c\u662f\u9020\u6210\u4e00\u6b72\u4ee5\u4e0b\u5b30\u5e7c\u5152\u4f4f\u9662\u6cbb\u7642\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u3002\u5c0d\u65bc\u9ad8\u5371\u96aa\u65cf\u7fa4\uff0c\u4f8b\u5982\u65e9\u7522\u5152\u6216\u5148\u5929\u6027\u5fc3\u81df\u75c5\u7684\u5e7c\u7ae5\uff0c\u56e0\u70ba\u4ed6\u5011\u81ea\u8eab\u62b5\u6297\u529b\u8f03\u5dee\uff0c\u6216\u76f8\u95dc\u5668\u5b98\u767c\u80b2\u6709\u7f3a\u9677\u6216\u672a\u81fb\u6210\u719f\uff0c\u4e00\u65e6\u611f\u67d3\uff0c\u5176\u75be\u75c5\u56b4\u91cd\u5ea6\u5e38\u9ad8\u65bc\u5176\u4ed6\u60a3\u8005\uff0c\u751a\u81f3\u9700\u8981\u4f4f\u9662\u6cbb\u7642\u3002<\/p>\n\n\n\n

RSV\u5982\u4f55\u8a3a\u65b7<\/strong><\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

\u3000\u3000\u901a\u5e38\u53ea\u5728\u5b30\u5152\u6709\u56b4\u91cd\u75c7\u72c0\u6642\u624d\u9700\u8981\u8a3a\u65b7\u3002\u91ab\u5e2b\u53ef\u80fd\u6703\u4f7f\u7528\u9f3b\u8154\u68c9\u68d2\u6216\u9f3b\u8154\u6c96\u6d17\u6db2\u6536\u96c6\u6aa2\u9ad4\uff0c\u53ef\u7528\u65bc\u6aa2\u67e5\u662f\u5426\u6709\u75c5\u6bd2\u3002\u4e5f\u53ef\u80fd\u958b\u7acb\u8840\u6db2\u6aa2\u6e2c\uff0c\u6216\u505a\u80f8\u8154X\u5149\u4f86\u6aa2\u67e5\u80ba\u708e\u3002<\/p>\n\n\n\n

\u9810\u9632\u52dd\u65bc\u6cbb\u7642<\/strong><\/p>\n\n\n\n

1.\u88ab\u52d5\u9810\u9632-\u300c\u897f\u90a3\u5409\u65af\u300dPalivizumab(Synagis\u00ae)<\/p>\n\n\n\n

\u3000\u3000\u82e5\u5e7c\u7ae5\u611f\u67d3RSV\uff0c\u76ee\u524d\u4e26\u7121\u5c0d\u61c9\u7684\u85e5\u7269\u53ef\u4f9b\u6cbb\u7642\uff0c\u901a\u5e38\u70ba\u652f\u6301\u6027\u7642\u6cd5\u3002\u53ea\u80fd\u5728\u5c1a\u672a\u611f\u67d3\u6642\u9810\u9632\u6027\u7d66\u4e88\u85e5\u7269\u300c\u897f\u90a3\u5409\u65af\u300d\uff0c\u53ef\u76f4\u63a5\u4f5c\u7528\u65bc\u75c5\u6bd2\u8868\u9762\u7684\u878d\u5408\u86cb\u767d\uff0c\u9632\u6b62\u75c5\u6bd2\u7d50\u5408\u65bc\u8868\u76ae\u7d30\u80de\u964d\u4f4e\u611f\u67d3\u98a8\u96aa\u3002\u4f46\u82e5\u611f\u67d3\u5f8c\u518d\u4f7f\u7528\u55ae\u682a\u6297\u9ad4\uff0c\u7642\u6548\u4e26\u4e0d\u660e\u78ba\u3002\u5efa\u8b70\u9810\u9632\u5291\u91cf\u70ba15mg\/kg\uff0c\u6bcf\u6708\u808c\u8089\u6ce8\u5c04\u4e00\u6b21\uff0c\u9023\u7e8c5\u500b\u6708\u53ef\u964d\u4f4e\u56e0RSV\u611f\u67d3\u800c\u4f4f\u9662\u7684\u6a5f\u7387\u3002\u76ee\u524d\u5065\u4fdd\u7d66\u4ed8\u65bc\u61f7\u5b55\u9031\u6578\u5c0f\u65bc\u6216\u7b49\u65bc30\u9031\u4e4b\u65e9\u7522\u5152\u3001\u61f7\u5b55\u9031\u6578\u226435\u9031\u5408\u4f75\u6162\u6027\u80ba\u75be\u75c5\u53ca\u67d0\u4e9b\u5148\u5929\u6027\u5fc3\u81df\u75c5\u7684\u75c5\u7ae5\uff0c\u53ef\u6bcf\u6708\u6295\u4e88\u4e00\u6b21\uff0c\u6700\u591a6\u6b21\u3002\u82e5\u7642\u7a0b\u4e2d\u767c\u751fRSV\u7684\u7a81\u7834\u6027\u611f\u67d3\u800c\u4f4f\u9662\uff0c\u61c9\u505c\u6b62\u6bcf\u500b\u6708\u7d66\u85e5\u3002<\/p>\n\n\n\n

2.\u4e00\u822c\u9810\u9632<\/p>\n\n\n\n

\u25cf\u9935\u54fa\u6bcd\u4e73\u2500\u56e0\u6bcd\u4e73\u542b\u514d\u75ab\u7403\u86cb\u767d\u8207\u5176\u4ed6\u514d\u75ab\u56e0\u5b50\uff0c\u53ef\u964d\u4f4e\u611f\u67d3\u7387\u8207\u75be\u75c5\u56b4\u91cd\u5ea6\u3002<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

\u25cf\u52e4\u6d17\u624b\u2500 \u624b\u90e8\u6c59\u67d3\u662f\u75c5\u6bd2\u50b3\u67d3\u7684\u91cd\u8981\u9014\u5f91\uff0c\u61c9\u52e4\u6d17\u624b\u3002<\/p>\n\n\n\n

\u25cf\u9152\u7cbe\u6d88\u6bd2\u2500 \u9152\u7cbe\u80fd\u6eb6\u89e3\u75c5\u6bd2\u5916\u5957\u819c\u4e0a\u4e4b\u8102\u8cea\uff0c\u9032\u800c\u7522\u751f\u6d88\u6bd2\u6bba\u83cc\u4e4b\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u25cf\u907f\u514d\u4e8c\u624b\u83f8\u2500 \u4e8c\u624b\u83f8\u6703\u589e\u52a0\u547c\u5438\u9053\u878d\u5408\u75c5\u6bd2\u7684\u611f\u67d3\u7387\uff0c\u61c9\u907f\u514d\u5b69\u7ae5\u66b4\u9732\u5728\u4e8c\u624b\u83f8\u7684\u74b0\u5883\u4e2d\u3002<\/p>\n\n\n\n

\u85e5\u7269\u7814\u767c\u73fe\u6cc1(<\/strong>\u55ae\u682a\u6297\u9ad4\/<\/strong>\u75ab\u82d7)<\/strong><\/p>\n\n\n\n

\u3000\u3000\u85e5\u5ee0AZ\u53ca\u8cfd\u8afe\u83f2\u6b63\u9032\u884c\u65b0\u578b\u9577\u6548\u7684\u55ae\u682a\u6297\u9ad4\u7684\u7814\u7a76\uff0c\u76ee\u6a19\u65cf\u7fa4\u70ba6\u500b\u6708\u4ee5\u4e0b\u65e9\u7522\u5152\uff0c\u4e0d\u7528\u50cf\u897f\u90a3\u5409\u65af\u9700\u8981\u6ce8\u5c045\u5291\uff0c\u53ea\u9700\u5728RSV\u6d41\u884c\u5b63\u7bc0\u6ce8\u5c04\u4e00\u5291\u4fbf\u80fd\u964d\u4f4e78.4%\u4e0b\u547c\u5438\u9053\u611f\u67d3\u98a8\u96aa\u4ee5\u53ca70.1%\u56e0\u611f\u67d3\u4f4f\u9662\u7684\u6a5f\u7387\uff0c\u76f8\u8f03\u65bc\u897f\u90a3\u5409\u65af\u8868\u73fe\u66f4\u4f73\u3002\u5728\u5065\u5eb7\u65b0\u751f\u5152\u76f8\u95dc\u7684\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\u8a66\u9a57\u6301\u7e8c\u9032\u884c\u4e2d\uff0c\u9810\u8a08\u5c07\u65bc2023\u5e74\u5b8c\u6210\u3002<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

\u3000\u3000\u800c\u570b\u885b\u9662\u75ab\u82d7\u4e2d\u5fc3\u7814\u767c\u4ee5\u817a\u75c5\u6bd2\u70ba\u8f09\u9ad4\u7684RSV\u75ab\u82d7\uff0c\u5468\u5f65\u5b8f\u7814\u7a76\u54e1\u5718\u968a\u5229\u7528\u9ecf\u819c\u6027\u8f09\u9ad4\u767c\u5c55\u5e36\u6709F\u86cb\u767d\u7684\u91cd\u7d44\u817a\u75c5\u6bd2\u75ab\u82d7(Ad-RSV)\uff0c\u80fd\u5920\u6709\u6548\u6291\u5236\u611f\u67d3\u80ba\u90e8\u7d44\u7e54\u7d30\u80de\u7684\u547c\u5438\u9053\u878d\u5408\u75c5\u6bd2\u91cf\uff0c\u9032\u800c\u964d\u4f4e\u80ba\u90e8\u7d44\u7e54\u7d30\u80de\u767c\u708e\u53ca\u9ad4\u91cd\u6e1b\u8f15\u7b49\u75c7\u72c0\u3002\u75ab\u82d7\u53ef\u4ee5\u6fc0\u767c\u75c5\u6bd2\u7279\u7570\u6027\u4e4bTh1\u7d30\u80de\u6027\u514d\u75ab\u53cd\u61c9\u7684\u6d3b\u5316\u53ca\u4e2d\u548c\u6027\u6297\u9ad4\u7684\u5f62\u6210\uff0c\u6709\u6548\u964d\u4f4e\u80ba\u90e8\u7d44\u7e54\u7d30\u80de\u7684\u75c5\u6bd2\u91cf\u3002\u7814\u7a76\u5718\u968a\u9032\u4e00\u6b65\u5206\u6790\u986f\u793a\u91cd\u7d44\u817a\u75c5\u6bd2\u75ab\u82d7\u5177\u6709\u964d\u4f4eRSV\u611f\u67d3\u4e4b\u75c5\u7406\u53cd\u61c9\u3002<\/p>\n\n\n\n

\u3000\u3000\u56e0\u76ee\u524d\u75ab\u82d7\u90fd\u5c1a\u5728\u7814\u767c\u671f\uff0c\u4f46\u75c5\u6bd2\u7684\u7a81\u8b8a\u537b\u662f\u65e5\u65b0\u6708\u7570\uff0c\u7dad\u6301\u826f\u597d\u7684\u751f\u6d3b\u7fd2\u6163\uff0c\u907f\u514d\u51fa\u5165\u611f\u67d3\u98a8\u96aa\u9ad8\u7684\u5834\u6240\uff0c\u5b88\u8b77\u5b69\u7ae5\u7684\u5065\u5eb7\uff0c\u8b93\u4ed6\u5011\u80fd\u5065\u5eb7\u5e73\u5b89\u5730\u9577\u5927\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u85e5\u5291\u79d1 \u694a\u7ffc\u4e98 \u85e5\u5e2b \u3000\u3000\u547c\u5438\u9053\u878d\u5408\u75c5\u6bd2(Respiratory Syncytial Virus, RSV)\u662f […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[123,188,189],"class_list":["post-4670","post","type-post","status-publish","format-standard","hentry","category-20","tag-123","tag-188","tag-189"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts\/4670"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4670"}],"version-history":[{"count":1,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts\/4670\/revisions"}],"predecessor-version":[{"id":4674,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts\/4670\/revisions\/4674"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4670"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4670"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4670"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}