{"id":4635,"date":"2022-02-01T16:23:03","date_gmt":"2022-02-01T08:23:03","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/cshmagazine\/?p=4635"},"modified":"2022-02-16T08:46:04","modified_gmt":"2022-02-16T00:46:04","slug":"%e4%bf%9d%e8%ad%b7%e5%9f%ba%e5%9b%a0%e7%9a%84%e5%81%a5%e5%ba%b7%ef%bc%8c%e5%b0%b1%e5%be%9e%e9%a3%b2%e9%a3%9f%e9%96%8b%e5%a7%8b%e5%90%a7%ef%bd%9e","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/?p=4635","title":{"rendered":"\u4fdd\u8b77\u57fa\u56e0\u7684\u5065\u5eb7\uff0c\u5c31\u5f9e\u98f2\u98df\u958b\u59cb\u5427\uff5e"},"content":{"rendered":"\n

\u71df\u990a\u79d1\u9673\u76c8\u7fbd\u71df\u990a\u5e2b<\/strong><\/p>\n\n\n\n

\u3000\u3000\u57fa\u56e0\u638c\u7ba1\u8457\u7d30\u80de\u7684\u58fd\u547d\uff0c1930\u5e74\u907a\u50b3\u5b78\u5bb6McClintock\u8207Muller\u5728\u771f\u6838\u7d30\u80de\u4e2d\u767c\u73fe\u7aef\u7c92\uff0c\u4f4d\u65bc\u57fa\u56e0\u672b\u7aef\uff0c\u4ee5\u91cd\u8907\u5e8f\u5217TTAGGG\u5b58\u5728\u65bc\u4eba\u9ad4\u4e2d\uff0c\u4f5c\u7528\u662f\u4fdd\u8b77\u67d3\u8272\u9ad4\u3001\u907f\u514d\u8207\u5176\u4ed6\u67d3\u8272\u9ad4\u878d\u5408\u4ee5\u53ca\u7a69\u5b9a\u57fa\u56e0\u7d50\u69cb\u3002\u7aef\u7c92\u662f\u4e00\u500b\u52d5\u614b\u7d50\u69cb\uff0c\u5176\u9577\u5ea6\u8207\u7d30\u80de\u5206\u88c2\u6b21\u6578\u6709\u95dc\uff0c\u6bcf\u9032\u884c\u4e00\u6b21\uff0c\u7aef\u7c92\u5c31\u6703\u96a8\u4e4b\u7e2e\u77ed\uff0c\u904e\u77ed\u7684\u7aef\u7c92\u5c07\u5931\u53bb\u529f\u80fd\uff0c\u7d30\u80de\u5247\u9032\u5165\u8870\u8001\u72c0\u614b\uff0c\u8a31\u591a\u7814\u7a76\u986f\u793a\u8870\u8001\u7d30\u80de\u7684\u5806\u7a4d\u662f\u9020\u6210\u8001\u5316\u8207\u76f8\u95dc\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\u3002<\/p>\n\n\n\n

\u3000\u3000\u6839\u64da\u7f8e\u570b\u75be\u75c5\u7ba1\u5236\u8207\u9810\u9632\u4e2d\u5fc3(CDC, 2009)\u8207\u4e16\u754c\u885b\u751f\u7d44\u7e54(WHO, 2005)\u89c0\u5bdf\u7684\u7d50\u679c\uff0c\u7aef\u7c92\u5206\u5b50\u4ee3\u8b1d\u8207\u8870\u8001\u76f8\u95dc\u4e4b\u75be\u75c5\u6709\u95dc\uff0c\u5982\u764c\u75c7\u3001\u7b2c2\u578b\u7cd6\u5c3f\u75c5\u3001\u51a0\u5fc3\u75c5\u7b49\uff0c\u6709\u8da3\u7684\u662f\uff0c\u9019\u4e9b\u75be\u75c5\u53ef\u900f\u904e\u6539\u8b8a\u751f\u6d3b\u578b\u614b\u4f86\u964d\u4f4e40%~80%\uff0c\u5982\u9032\u884c\u6297\u8001\u5316\u98f2\u98df\u8207\u9069\u5ea6\u53ca\u898f\u5f8b\u7684\u9ad4\u80fd\u6d3b\u52d5\u3002<\/p>\n\n\n\n

\u4ec0\u9ebc\u6771\u897f\u6703\u589e\u52a0\u57fa\u56e0\u640d\u58de\u7684\u5371\u96aa\uff0c\u9032\u800c\u5f71\u97ff\u7aef\u7c92\u5462\uff1f<\/strong><\/p>\n\n\n\n

\u3000\u3000\u57282018\u5e74\u7f8e\u570b\u7684\u7814\u7a76\u4e2d\u63d0\u5230\u4e86\u81ea\u7531\u57fa\u3002\u90a3\u4eba\u9ad4\u5167\u7684\u81ea\u7531\u57fa\u53c8\u5f9e\u54ea\u88e1\u4f86\uff1f\u7c92\u817a\u9ad4\u7a31\u70ba\u7d30\u80de\u7684\u767c\u96fb\u5ee0\uff0c\u53ef\u5c07\u78b3\u6c34\u5316\u5408\u7269\u8f49\u63db\u6210\u70baATP\uff0c\u63d0\u4f9b\u7d30\u80de\u80fd\u91cf\uff0c\u5728\u9019\u500b\u904e\u7a0b\u4e2d\u5373\u6703\u7522\u751f\u81ea\u7531\u57fa\uff0c\u6d3b\u6027\u6c27\u5206\u5b50(Reactive oxygenspecies, ROS)\uff0c\u5728\u7d50\u69cb\u4e0a\u6709\u672a\u914d\u5c0d\u7684\u81ea\u7531\u96fb\u5b50\uff0c\u5176\u5177\u6709\u5f88\u5f37\u7684\u5316\u5b78\u53cd\u61c9\u6d3b\u6027\uff0c\u6703\u9020\u6210\u57fa\u56e0\u7684\u4e0d\u7a69\u5b9a\uff0c\u5df2\u6709\u8a31\u591a\u7814\u7a76\u6307\u51fa\u7d30\u80de\u8870\u8001\u8207\u529f\u80fd\u5931\u8abf\u7684\u7c92\u817a\u9ad4\u548c\u8f03\u77ed\u7684\u7aef\u7c92\u6709\u95dc\u3002<\/p>\n\n\n\n

\u54ea\u4e9b\u71df\u990a\u7d20\u3001\u98f2\u98df\u53ef\u4ee5\u4fdd\u8b77\u7aef\u7c92\u5462\uff1f<\/strong><\/p>\n\n\n\n

\u3000\u3000\u7814\u7a76\u986f\u793a\u53ef\u4ee5\u98df\u7528\u5177\u6709\u6297\u6c27\u5316\u7684\u71df\u990a\u7d20\u4f86\u6d88\u9664\u81ea\u7531\u57fa\uff0c\u63a5\u4e0b\u4f86\u5c07\u7c21\u8981\u4ecb\u7d39\u7dad\u751f\u7d20\u3001\u7926\u7269\u8cea\u3001\u591a\u915a\u548comega-3 \u8102\u80aa\u9178\u5c0d\u8001\u5316\u7684\u5f71\u97ff\u3002<\/p>\n\n\n\n

\uff11\uff0e\u7dad\u751f\u7d20\u8207\u7926\u7269\u8cea<\/strong><\/p>\n\n\n\n

\u3000\u3000\u7dad\u751f\u7d20C\u3001D\u3001E\u3001\u8449\u9178\u3001\u03b2\u80e1\u863f\u8514\u7d20\uff0c\u7926\u7269\u8cea\u92c5\u3001\u9382\uff0c\u7686\u80fd\u589e\u52a0\u6297\u6c27\u5316\u529b\uff0cPaul\u7b49\u4eba\u57282011\u5e74\u7684\u7814\u7a76\u4e2d\u8868\u793a\u53ef\u4fdd\u8b77\u7aef\u7c92\u9577\u5ea6\u3002<\/p>\n\n\n\n

\uff12\uff0e\u5929\u7136\u5b58\u5728\u7684\u591a\u915a<\/strong><\/p>\n\n\n\n

\u3000\u3000\u8336\u9ec3\u7d20\u3001\u7da0\u8336\u8207\u7d05\u8336\u4e2d\u7684\u591a\u915a\uff0c\u4e5f\u5177\u6709\u6297\u6c27\u5316\u529b\uff0c\u53ef\u964d\u4f4e\u9ad4\u5167\u767c\u708e\u53cd\u61c9\uff0c\u6b64\u5916Chan\u7b49\u4eba\u57282010\u5e74\u7684\u7814\u7a76\u89c0\u5bdf\u4e2d\uff0c\u767c\u73fe\u6709\u559d\u8336\u7fd2\u6163\u7684\u4e2d\u570b\u7537\u6027\u8001\u5e74\u4eba\uff0c\u6709\u8f03\u9577\u7684\u7aef\u7c92\uff0c\u8207\u4e0d\u7d93\u5e38\u559d\u8336\u7684\u8001\u5e74\u4eba\u6bd4\u8f03\uff0c\u5176\u5e73\u5747\u58fd\u547d\u589e\u52a0\u4e865\u5e74\u3002<\/p>\n\n\n\n

\uff13\uff0eOmega-3\u8102\u80aa\u9178<\/strong><\/p>\n\n\n\n

\u3000\u3000\u5df2\u88ab\u4e16\u754c\u516c\u8a8d\u70ba\u662f\u4fc3\u9032\u5065\u5eb7\u7684\u8102\u80aa\u9178\uff0c\u4eba\u9ad4\u5167Omega-3\u8207Omega-6\u8102\u80aa\u9178\u7684\u6bd4\u4f8b\u8207\u7aef\u7c92\u9577\u5ea6\u6709\u95dc\uff0cFarzaneh-Far\u7b49\u4eba\u65bc2010\u5e74\u7814\u7a76\u4e2d\u8868\u793a\u8f03\u9ad8\u7684Omega-3\u8102\u80aa\u9178\u6fc3\u5ea6\u8207\u7aef\u7c92\u8017\u640d\u5448\u8ca0\u76f8\u95dc\uff0c\u5177\u6709\u4fdd\u8b77\u57fa\u56e0\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n

\uff14\uff0e\u98f2\u98df\u7d44\u6210<\/strong><\/p>\n\n\n\n

\u3000\u3000\u6839\u64daLopez-Garcia\u7684\u7814\u7a76\u8868\u793a\u65b0\u9bae\u6c34\u679c\u3001\u852c\u83dc\u3001\u8c46\u985e\u3001\u9b5a\u3001\u5bb6\u79bd\u985e\u8207\u5168\u7a40\u7269\u7684\u651d\u53d6\uff0c\u80fd\u964d\u4f4e\u767c\u708e\u53cd\u61c9\uff0c\u53e6\u5916Freitas-Simoesy\u7b49\u4eba\u57282016\u5e74\u7814\u7a76\u4e2d\u4e5f\u6307\u51fa\u5176\u4ed6\u6297\u6c27\u5316\u98df\u7269\u5982\u7a2e\u5b50\u3001\u5805\u679c\u3001\u8c46\u985e\u3001\u6d77\u85fb\u548c\u5496\u5561\u4e5f\u8207\u4fdd\u8b77\u7aef\u7c92\u9577\u5ea6\u6709\u95dc\u806f\u3002<\/p>\n\n\n\n

\u3000\u3000\u6b64\u5916\uff0c\u5728\u5176\u4ed6\u76f8\u95dc\u7814\u7a76\u4e2d\u8207\u98df\u7269\u7a2e\u985e\u6709\u95dc\u7684\uff1a\u7a40\u7269\u8207\u5168\u7a40\u7269\u7684\u81b3\u98df\u7e96\u7dad\u651d\u53d6\u91cf\uff0c\u5c0d\u5973\u6027\u7684\u7aef\u7c92\u9577\u5ea6\u5177\u6709\u4fdd\u8b77\u4f5c\u7528(Cassidy, 2010)\uff1b\u651d\u53d6\u52a0\u5de5\u8089\u985e\u5247\u6703\u6e1b\u5c11\u7aef\u7c92\u9577\u5ea6(Nettleton, 2008)\u3002<\/p>\n\n\n\n

\u3000\u3000\u6297\u6c27\u5316\u5291\u7684\u6700\u4f73\u4f86\u6e90\u662f\u98df\u7269\uff0c\u800c\u4e0d\u662f\u88dc\u5145\u5291\u3002\u5929\u7136\u98df\u7269\u4e2d\u6709\u591a\u7a2e\u690d\u5316\u7269\u8207\u7121\u6cd5\u9032\u884c\u4eba\u5de5\u8403\u53d6\u7684\u6210\u5206\uff0c\u5177\u6709\u5354\u540c\u4f5c\u7528\uff0c\u975e\u52a0\u5de5\u5408\u6210\u7684\u88dc\u5145\u5291\u53ef\u53d6\u4ee3\u3002<\/p>\n\n\n\n

\u76ee\u524d\u4e16\u754c\u4e0a\u54ea\u7a2e\u98f2\u98df\u65b9\u5f0f\u662f\u6700\u80fd\u4fdd\u8b77\u57fa\u56e0\u7684\u5065\u5eb7\u5462\uff1f<\/strong><\/p>\n\n\n\n

\u7b54\u6848\u662f\u5730\u4e2d\u6d77\u98f2\u98df\uff01<\/strong><\/p>\n\n\n\n

\u3000\u3000\u8fd1\u4e00\u3001\u4e8c\u5341\u5e74\u4f86\uff0c\u5df2\u88ab\u4e16\u754c\u773e\u591a\u91ab\u5b78\u5be6\u8b49\u7814\u7a76\u8a8d\u53ef\u70ba\u6700\u5065\u5eb7\u7684\u98f2\u98df\u4e4b\u4e00\uff0c\u76f8\u4fe1\u8a31\u591a\u6c11\u773e\u4e00\u5b9a\u4e5f\u6709\u807d\u904e\uff0c\u5730\u4e2d\u6d77\u98f2\u98df\u7684\u539f\u5247\u662f\u651d\u53d6\u65b0\u9bae\u6c34\u679c\u3001\u852c\u83dc\u3001\u5805\u679c\u548c\u7a2e\u5b50\u3001\u5168\u7a40\u985e\u3001\u6a44\u6b16\u6cb9\u3001\u9b5a\u548c\u4f4e\u8102\u8089\u985e\u3001\u4e73\u88fd\u54c1\u53ca\u9069\u91cf\u651d\u5165\u9152\u7cbe\uff0c\u651d\u53d6\u5bcc\u542b\u6297\u6c27\u5316\u529b\u7684\u98df\u7269\uff0c\u53ef\u964d\u4f4e\u9ad4\u5167\u767c\u708e\u53cd\u61c9\u53ca\u6e1b\u5c11\u81ea\u7531\u57fa\uff0c\u9032\u800c\u964d\u4f4e\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u6162\u6027\u75c5\u7684\u767c\u751f\u7387\uff0c\u5ef6\u9577\u58fd\u547d\u3002\u6b64\u5916\uff0c\u9084\u80fd\u523a\u6fc0\u5916\u5468\u8840\u55ae\u6838\u7d30\u80de(peripheral blood mononuclear cells)\u4e2d\u7684\u7aef\u7c92\u9176\u6d3b\u6027(Freitas-Simoes,2016)\uff0c\u518d\u914d\u5408\u9069\u5ea6\u904b\u52d5\uff0c\u53ef\u9577\u671f\u6539\u5584\u5167\u76ae\u5fae\u8840\u7ba1\u53ca\u5fc3\u80ba\u529f\u80fd(Klonizakis, 2014)\uff0c\u5c0d\u65bc\u5065\u5eb7\u975e\u5e38\u91cd\u8981\u3002<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

\u3000\u3000\u76ee\u524d\u91ab\u5b78\u4ecd\u6301\u7e8c\u7814\u7a76\u8870\u8001\u6a5f\u5236\u8207\u6297\u8870\u8001\uff0c\u7aef\u7c92\u7e2e\u77ed\u5df2\u88ab\u78ba\u5b9a\u70ba\u8870\u8001\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00(Vidacek,2010)\u3002\u8870\u8001\u662f\u7121\u6cd5\u907f\u514d\u7684\uff0c\u5f9e\u51fa\u751f\u8d77\u5c31\u662f\u9762\u5c0d\u8001\u5316\u7684\u958b\u59cb\uff0c\u800c\u73fe\u5728\u6211\u5011\u53ef\u4ee5\u900f\u904e\u6700\u57fa\u672c\u7684\u98f2\u98df\u4f86\u8457\u624b\uff0c\u5c31\u6709\u6a5f\u6703\u5ef6\u9577\u58fd\u547d\uff0c\u751f\u6d3b\u65b9\u5f0f\u7684\u6539\u8b8a\u5c31\u662f\u6700\u91cd\u8981\u7684\u958b\u59cb\u3002\u53c3\u8003\u8cc7\u6599: https:\/\/www.cdc.gov\/, https:\/\/www.who.int\/, J Gerontol A Biol SciMed Sci, 2018, Vol. 73, No. 1, 39\u201347<\/p>\n","protected":false},"excerpt":{"rendered":"

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