{"id":3821,"date":"2021-04-09T10:52:34","date_gmt":"2021-04-09T02:52:34","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/cshmagazine\/?p=3821"},"modified":"2021-06-24T14:42:15","modified_gmt":"2021-06-24T06:42:15","slug":"%e5%b9%b9%e7%b4%b0%e8%83%9e%e7%b0%a1%e4%bb%8b-%e5%be%9e%e9%80%a0%e8%a1%80%e5%b9%b9%e7%b4%b0%e8%83%9e%e5%88%b0%e9%96%93%e8%b3%aa%e5%b9%b9%e7%b4%b0%e8%83%9e","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/?p=3821","title":{"rendered":"\u5e79\u7d30\u80de\u7c21\u4ecb \u5f9e\u9020\u8840\u5e79\u7d30\u80de\u5230\u9593\u8cea\u5e79\u7d30\u80de"},"content":{"rendered":"\n

\u6587\/\u4e2d\u5c71\u91ab\u5b78\u5927\u5b78\u9644\u8a2d\u91ab\u9662 \u91ab\u4e8b\u90e8 \u5deb\u5eb7\u7199<\/strong> \u526f\u9662\u9577
\u5152\u7ae5\u8840\u6db2\u816b\u7624\u79d1 \u4e3b\u6cbb\u91ab\u5e2b<\/p>\n\n\n\n

\u4f55\u8b02\u7d30\u80de\u6cbb\u7642<\/strong><\/p>\n\n\n\n

\u7528\u7d30\u80de\u4f86\u6cbb\u7642\u75be\u75c5\u6216\u53d7\u50b7\u7684\u7d44\u7e54\uff0c\u4f8b\u5982\u5e38\u7528\u7684\u7d05\u8840\u7403\u6cbb\u7642\u8ca7\u8840\uff0c\u5c31\u662f\u6240\u8b02\u7684\u7d30\u80de\u6cbb\u7642\uff0c\u7d30\u80de\u6cbb\u7642\u6709\u5e7e\u500b\u91cd\u9ede\u9700\u8981\u6ce8\u610f\uff0c\u5982\uff1a\u54ea\u7a2e\u7d30\u80de\u9069\u5408\u6cbb\u7642\u54ea\u7a2e\u75be\u75c5\u3001\u76f4\u63a5\u6253\u5165\u53d7\u50b7\u7d44\u7e54\u6216\u7531\u8840\u7ba1\u4e2d\u6ce8\u5165\u3001\u6cbb\u7642\u7684\u6a5f\u8f49\u2026\u7b49\u554f\u984c\uff0c\u9019\u4e9b\u90fd\u662f\u7d30\u80de\u6cbb\u7642\u9700\u8981\u6ce8\u610f\u7684\u554f\u984c\u3002\u800c\u7d30\u80de\u6cbb\u7642\u548c\u5176\u4ed6\u91ab\u7642\u76f8\u540c\uff0c\u4e5f\u5e38\u9700\u8981\u6ce8\u610f\u771f\u5047\uff0c\u5982\uff1a\u97d3\u570b\u9ec3\u79b9\u932b\u3001\u65e5\u672c\u5c0f\u4fdd\u65b9\u6674\u5b50\u3001\u7f8e\u570b\u54c8\u4f5b\u5927\u5b78\u2026\u7b49\u7814\u7a76\u9020\u5047\u4e8b\u4ef6\u3002\u76ee\u524d\u56e0\u70ba\u8a8d\u70ba\u5e79\u7d30\u80de\u53ef\u5206\u6ccc\u8a31\u591a\u7684\u7269\u8cea(paracrine)\u4f86\u4fee\u5fa9\u53d7\u50b7\u7684\u7d44\u7e54\uff0c\u6240\u4ee5\u5e79\u7d30\u80de\u662f\u7d30\u80de\u6cbb\u7642\u5f88\u597d\u7684\u4f86\u6e90\u4e4b\u4e00\u3002<\/p>\n\n\n\n

\u5e79\u7d30\u80de\u7684\u5b9a\u7fa9\u548c\u5206\u985e<\/strong><\/p>\n\n\n\n

\u5e79\u7d30\u80de\u4e00\u822c\u7684\u5b9a\u7fa9\u70ba\u4e00\u7fa4\u5177\u6709\u300c\u81ea\u6211\u589e\u751f(self-renew)\u300d\u548c\u300c\u5f80\u4e0b\u5206\u5316\u6216\u5176\u4ed6\u7d30\u80de\u300d\u7684\u672a\u5206\u5316\u7d30\u80de\uff0c\u4ee5\u5206\u5316\u7684\u80fd\u529b\u53ef\u5206\u70ba\uff1a(1)\u5168\u80fd\u5e79\u7d30\u80de(Totipotent)\uff0c\u5982\u53d7\u7cbe\u5375\uff1b(2)\u842c\u80fd\u5e79\u7d30\u80de(Pluripotent)\uff0c\u5982\u80da\u80ce\u5e79\u7d30\u80de(ESC)\u548c\u4eba\u5de5\u8a98\u5c0e\u591a\u80fd\u5e79\u7d30\u80de(iPSC)\uff1b(3)\u591a\u80fd\u5e79\u7d30\u80de(Multipotent)\uff0c\u5982\u9020\u8840\u5e79\u7d30\u80de(HSC)\u548c\u9593\u8cea\u5e79\u7d30\u80de(MSC)\uff1b(4)\u55ae\u80fd\u5e79\u7d30\u80de\u3002\u5728\u5e79\u7d30\u80de\u4e2d\uff0c\u76ee\u524d\u4f7f\u7528\u6700\u591a\u5e74\u548c\u6700\u6210\u719f\u7684\u5e79\u7d30\u80de\u662f\u9020\u8840\u5e79\u7d30\u80de\uff0c\u800c\u8fd1\u5e74\u4f86\u6700\u71b1\u9580\u88ab\u7814\u7a76\u548c\u8a0e\u8ad6\u7684\u662f\u9593\u8cea\u5e79\u7d30\u80de\uff0c\u56e0\u6b64\u4ee5\u4e0b\u4e3b\u8981\u8a0e\u8ad6\u9020\u8840\u5e79\u7d30\u80de\u548c\u9593\u8cea\u5e79\u7d30\u80de\u3002<\/p>\n\n\n\n

\u9020\u8840\u5e79\u7d30\u80de <\/strong><\/p>\n\n\n\n

Thomas\u56e0\u9aa8\u9ad3\u79fb\u690d\u65bc1957\u5e74\u7372\u8afe\u8c9d\u723e\u734e\uff0c\u4ee5\u524d\u7684\u9aa8\u9ad3\u79fb\u690d\uff0c\u88ab\u7a31\u70ba\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\uff0c\u6240\u4ee5\u9aa8\u9ad3\u79fb\u690d\u548c\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u662f\u76f8\u540c\u7684\u6cbb\u7642\uff0c\u56e0\u65e9\u671f\u9020\u8840\u5e79\u7d30\u80de\u4e3b\u8981\u4f86\u81ea\u9aa8\u9ad3\uff0c\u6240\u4ee5\u7a31\u9aa8\u9ad3\u79fb\u690d\u3002<\/p>\n\n\n\n

\u56e0\u62bd\u9aa8\u9ad3\u5c0d\u6350\u8005\u6bd4\u8f03\u4fb5\u5165\u6027(invasive)\uff0c\u6240\u4ee5\u73fe\u5728\u5927\u591a\u7528\u5468\u908a\u9020\u8840\u5e79\u7d30\u80de\u4f86\u53d6\u4ee3\u9aa8\u9ad3\uff0c\u6350\u5468\u908a\u9020\u8840\u5e79\u7d30\u80de\u524d\u75c5\u60a3\u9700\u65bd\u6253\u767d\u8840\u7403\u751f\u6210\u6fc0\u7d20(G-CSF)\uff0c\u5c07\u9aa8\u9ad3\u4e2d\u7684\u9020\u8840\u5e79\u7d30\u80de\u9a45\u8d95\u5230\u5468\u908a\u8840\u6db2\u3002\u4e4b\u5f8c\u5982\u6350\u8840\u4e00\u822c\u7531\u6a5f\u5668\u4f86\u6536\u96c6\uff0c\u800c\u5f8c\u5c07\u6536\u96c6\u5230\u7684\u5468\u908a\u9020\u8840\u5e79\u7d30\u80de\uff0c\u50cf\u8f38\u8840\u4e00\u822c\u7531\u8840\u7ba1\u8f38\u5165\u75c5\u60a3\u9ad4\u5167\u3002\u5468\u908a\u9020\u8840\u5e79\u7d30\u80de\u7684\u6536\u96c6\u5c0d\u6350\u8005\u800c\u8a00\uff0c\u9664\u6253\u91dd\u548cG-CSF\u77ed\u66ab\u7684\u75bc\u75db\u5916\uff0c\u4e26\u7121\u9577\u671f\u526f\u4f5c\u7528\uff0c\u6240\u4ee5\u5982\u6709\u88ab\u901a\u77e5\u5408\u9069\u7684\u9aa8\u9ad3(\u9020\u8840\u5e79\u7d30\u80de)\u6350\u8d08\u8005\uff0c\u8acb\u591a\u9f13\u52f5\uff0c\u6551\u4eba\u4e00\u547d\uff0c\u529f\u5fb7\u7121\u91cf\u3002<\/p>\n\n\n\n

\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u4e3b\u8981\u7528\u65bc\u6cbb\u7642\u9aa8\u9ad3\u548c\u8840\u6db2\u76f8\u95dc\u7684\u75be\u75c5\uff0c\u5982\u8840\u764c\u548c\u518d\u751f\u4e0d\u826f\u6027\u8ca7\u8840\u2026\u7b49\uff0c\u7528\u5225\u4eba\u7684\u9020\u8840\u5e79\u7d30\u80de\u53d6\u4ee3\u5df2\u75c5\u8b8a\u7684\u9aa8\u9ad3\uff0c\u7a31\u300c\u7570\u9ad4\u9aa8\u9ad3\u79fb\u690d\u300d\uff1b\u7528\u5f88\u5f37\u7684\u5316\u7642\u6216\u653e\u5c04\u7dda\u6bb2\u6ec5\u764c\u7d30\u80de(\u5982\u6dcb\u5df4\u764c)\uff0c\u518d\u5c07\u81ea\u5df1\u4ee5\u524d\u6536\u96c6\u7684\u9020\u8840\u5e79\u7d30\u80de\u56de\u8f38\u7d66\u81ea\u5df1\uff0c\u7a31\u300c\u81ea\u9ad4\u9aa8\u9ad3\u79fb\u690d\u300d\u3002<\/p>\n\n\n\n

\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u6700\u56f0\u96e3\u7684\u662f\u79fb\u690d\u5f8c\u7684\u7167\u9867\uff0c\u7279\u5225\u662f\u7570\u9ad4\u9aa8\u9ad3\u79fb\u690d\uff0c\u56e0\u75c5\u60a3\u79fb\u690d\u524d\uff0c\u7d93\u5f88\u5f37\u7684\u5316\u7642(\u6216\u653e\u5c04\u7dda\u6cbb\u7642)\u5f15\u8d77\u7684\u526f\u4f5c\u7528\u3001\u8840\u7403\u4f4e\u4e0b\u53ca\u62b5\u6297\u529b\u4f4e\u4e0b\u5e38\u9020\u6210\u56b4\u91cd\u611f\u67d3\u3001\u690d\u5165\u6350\u8d08\u8005\u7684\u6dcb\u5df4\u7403\u653b\u64ca\u75c5\u4eba\u9020\u6210\u300c\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75be\u75c5\u300d\u2026\u7b49\uff0c\u9019\u4e9b\u4f75\u767c\u75c7\u5e38\u9700\u8981\u5f88\u6709\u7d93\u9a57\u5718\u968a\uff0c\u5c07\u554f\u984c\u4e00\u4e00\u514b\u670d\u3002<\/p>\n\n\n\n

\u81cd\u5e36\u8840\u56e0\u542b\u6709\u6bd4\u4f8b\u8f03\u9ad8\u7684\u9020\u8840\u5e79\u7d30\u80de\uff0c\u6240\u4ee5\u57281988\u5e74\u8d77\u88ab\u7576\u6210\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u7684\u4f86\u6e90\u4e4b\u4e00\uff0c\u4f46\u56e0\u81cd\u5e36\u8840\u91cf\u5167\u542b\u7684\u9020\u8840\u5e79\u7d30\u80de\u6709\u9650\uff0c\u56e0\u6b64\u5927\u591a\u61c9\u7528\u5728\u5152\u7ae5\u75c5\u60a3\u3002\u7531\u7236\u6bcd\u6216\u5b50\u5973\u7576\u6350\u8d08\u8005\u7684\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\uff0c\u7a31\u70ba\u534a\u543b\u5408\u79fb\u690d\uff0c\u4ee5\u524d\u5f88\u96e3\u6210\u529f\uff0c\u96a8\u8457\u79fb\u690d\u6280\u8853\u7684\u7a81\u7834\u548c\u9032\u6b65\uff0c\u6210\u529f\u7387\u5df2\u5927\u5e45\u63d0\u5347\u3002<\/p>\n\n\n\n

\u4e2d\u5c71\u91ab\u7642\u5718\u968a\u79fb\u690d\u591a\u4f8b\u7684\u534a\u543b\u5408\u79fb\u690d\uff0c\u96d6\u6709\u5176\u56f0\u96e3\u5ea6\uff0c\u4f46\u6210\u529f\u7387\u76f8\u7576\u4e0d\u932f\uff0c\u5728\u6c92\u6709\u9069\u7576\u7684\u6350\u8d08\u8005\u6642\uff0c\u534a\u543b\u5408\u79fb\u690d\u662f\u500b\u53ef\u884c\u7684\u9078\u64c7\u3002\u8fd1\u5e74\u4f86\u9760\u57fa\u56e0\u6539\u9020\u75c5\u60a3\u7684\u9020\u8840\u5e79\u7d30\u80de\uff0c\u518d\u690d\u5165\u75c5\u60a3\u8eab\u4e0a\uff0c\u6210\u529f\u6cbb\u7642\u91cd\u5ea6\u6d77\u6d0b\u6027\u8ca7\u8840\uff0c\u7528\u9020\u8840\u5e79\u7d30\u80de\u6cbb\u7642\u8166\u90e8\u3001\u5fc3\u81df\u2026\u7b49\u75be\u75c5\u4e5f\u6709\u4e0d\u5c11\u7684\u7814\u7a76\u548c\u5831\u5c0e\uff0c\u4f46\u5176\u771f\u6b63\u7684\u6548\u679c\uff0c\u9700\u5927\u5bb6\u518d\u4e00\u540c\u52aa\u529b\u3002<\/p>\n\n\n\n

\u9593\u8cea\u5e79\u7d30\u80de<\/strong><\/p>\n\n\n\n

\u9593\u8cea\u5e79\u7d30\u80de\u662f\u8fd1\u5e74\u4f86\u88ab\u5ee3\u6cdb\u7814\u7a76\u7684\u5e79\u7d30\u80de\u4e4b\u4e00\uff0c\u56e0\u672c\u8eab\u7684\u4f4e\u6297\u539f\u6027\uff0c\u4e0d\u7528\u50cf\u9020\u8840\u5e79\u7d30\u80de\u8981\u6350\u8d08\u8005\u548c\u75c5\u60a3\u7684\u76f8\u7576\u543b\u5408\u5ea6(HLA\nmatch)\uff0c\u53ef\u88ab\u5ee3\u6cdb\u4f7f\u7528\u3002\u9593\u8cea\u5e79\u7d30\u80de\u53ef\u81ea\u9aa8\u9ad3\u3001\u8102\u80aa\u3001\u7259\u9f52\u3001\u81cd\u5e36\u3001\u81cd\u5e36\u8840\u3001\u7f8a\u819c\u3001\u80ce\u76e4\u2026\u7b49\u7d44\u7e54\u4e2d\u5206\u96e2\u51fa\u4f86\uff0c\u5177\u6709\u6297\u767c\u708e\u3001\u4fee\u5fa9\u53d7\u50b7\u7d44\u7e54\u7b49\u7279\u6027\uff0c\u6240\u4ee5\u61c9\u7528\u5230\u8a31\u591a\u7684\u75be\u75c5\uff0c\u5982\u514d\u75ab\u7570\u5e38\u3001\u9000\u5316\u6027\u95dc\u7bc0\u708e\u3001\u8166\u90e8\u640d\u50b7\u3001\u5fc3\u81df\u2026\u7b49\u75be\u75c5\u3002<\/p>\n\n\n\n

2021\u5e74\u7f8e\u570b\u767c\u8868\u81cd\u5e36\u9593\u8cea\u5e79\u7d30\u80de\u5c0d\u56b4\u91cd\u65b0\u51a0\u80ba\u708e\u611f\u67d3\u5f15\u8d77\u7684\u6025\u6027\u547c\u5438\u7a98\u8feb\u75c7\u5019\u7fa4(ARDS)\uff0c\u53ef\u660e\u986f\u6539\u5584\u5b58\u6d3b\u7387\u3002\u6211\u5011\u5718\u968a\u7684\u52d5\u7269\u5be6\u9a57\uff0c\u4e5f\u8b49\u5be6\u9593\u8cea\u5e79\u7d30\u80de\u5c0d\u6025\u6027\u80ba\u640d\u50b7\uff0c\u78ba\u5be6\u6709\u4fee\u5fa9\u7684\u6548\u679c\uff0c\u9593\u8cea\u5e79\u7d30\u80de\u96d6\u5df2\u6709\u8a31\u591a\u7684\u767c\u8868\uff0c\u4f46\u4ecd\u5b58\u5728\u8457\u592a\u591a\u7684\u672a\u77e5\uff0c\u503c\u5f97\u5927\u5bb6\u6df1\u5165\u7814\u7a76\u548c\u8a0e\u8ad6\u3002<\/p>\n\n\n\n

\u7d50\u8ad6<\/strong><\/p>\n\n\n\n

\u6211\u5011\u5718\u968a\u5f9e\u4e8b\u9020\u8840\u5e79\u7d30\u80de20\u591a\u5e74\uff0c\u5305\u62ec\u81cd\u5e36\u8840\u79fb\u690d\u548c\u8f03\u9ad8\u96e3\u5ea6\u7684\u534a\u543b\u5408\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\uff0c\u5e0c\u671b\u5c07\u4f86\u53ef\u5c07\u9020\u8840\u5e79\u7d30\u80de\u61c9\u7528\u5230\u66f4\u591a\u7684\u75be\u75c5\u3002\u6211\u5011\u7684\u5718\u968a\u7814\u7a76\u9593\u8cea\u5e79\u7d30\u80de\u4e5f\u5df210\u591a\u5e74\uff0c\u767c\u886820\u591a\u7bc7SCI\u7684\u671f\u520a\uff0c\u5f9e\u57fa\u790e\u3001\u52d5\u7269\u5230\u4eba\u9ad4\uff0c\u5df2\u8b49\u5be6\u9593\u8cea\u5e79\u7d30\u80de\u6709\u5f88\u597d\u7684\u514d\u75ab\u8abf\u7bc0\u529f\u80fd(immunomodulation)\uff0c\u4e5f\u5e0c\u671b\u5c07\u4f86\u80fd\u5c07\u9593\u8cea\u5e79\u7d30\u80de\u61c9\u7528\u5230\u66f4\u591a\u7684\u75be\u75c5\uff0c\u7279\u5225\u662f\u514d\u75ab\u76f8\u95dc\u7684\u75be\u75c5\uff0c\u4ee5\u5e6b\u52a9\u66f4\u591a\u7684\u75c5\u4eba\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6587\/\u4e2d\u5c71\u91ab\u5b78\u5927\u5b78\u9644\u8a2d\u91ab\u9662 \u91ab\u4e8b\u90e8 \u5deb\u5eb7\u7199 \u526f\u9662\u9577\u5152\u7ae5\u8840\u6db2\u816b\u7624\u79d1 \u4e3b\u6cbb\u91ab\u5e2b \u4f55\u8b02\u7d30\u80de\u6cbb\u7642 \u7528\u7d30\u80de\u4f86\u6cbb\u7642\u75be\u75c5\u6216\u53d7\u50b7 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[110],"class_list":["post-3821","post","type-post","status-publish","format-standard","hentry","category-19","tag-110"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts\/3821"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3821"}],"version-history":[{"count":2,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts\/3821\/revisions"}],"predecessor-version":[{"id":3962,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=\/wp\/v2\/posts\/3821\/revisions\/3962"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3821"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3821"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}