{"id":373,"date":"2020-05-09T15:58:54","date_gmt":"2020-05-09T07:58:54","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/cshmagazine\/?p=373"},"modified":"2020-05-13T11:13:22","modified_gmt":"2020-05-13T03:13:22","slug":"%e4%b8%8d%e5%8f%af%e8%bc%95%e5%bf%bd%e7%9a%84%e9%9a%b1%e5%bd%a2%e6%ae%ba%e6%89%8b%e9%ab%98%e8%a1%80%e8%84%82","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/cshmagazine\/?p=373","title":{"rendered":"\u4e0d\u53ef\u8f15\u5ffd\u7684\u96b1\u5f62\u6bba\u624b-\u9ad8\u8840\u8102"},"content":{"rendered":"\n

\u6587<\/strong>\/<\/strong>\u4e2d\u897f\u6574\u5408\u91ab\u7642\u79d1<\/strong> <\/strong>\u6797\u69ae\u5fd7<\/strong> <\/strong>\u4e3b\u4efb<\/strong> <\/strong><\/p>\n\n\n\n

\u6d2a\u5a49\u771f \u7814\u7a76\u52a9\u7406<\/strong><\/p>\n\n\n\n

\u4e2d\u91ab\u5b78\u5c0d\u80a5\u80d6\u75c7\u7684\u8a8d\u8b58\u6e90\u9060\u6d41\u9577\uff0c\u6700\u65e9\u7684\u4e2d\u91ab\u7d93\u5178\u8457\u4f5c\u300a\u5167\u7d93\u300b\u5c31\u6709\u4e0d\u5c11\u95dc\u65bc\u80a5\u80d6\u75c7\u53ca\u5176\u4f75\u767c\u75c7\u7684\u8a8d\u8b58\uff0c\u5982\u201c\u7518\u80a5\u8cb4\u4eba\uff0c\u5247\u818f\u6881\u4e4b\u75be\u4e5f\u201d\uff0c\u201c\u6b64\u80a5\u7f8e\u4e4b\u767c\u4e5f\u201d\uff0c\u300a\u79ae\u8a18\u300b\u4ea6\u6709\u80a5\u80d6\u7684\u8a18\u8f09\uff1a\u201c\u819a\u9769\u5145\u76c8\uff0c\u4eba\u4e4b\u80a5\u4e5f\u3002\u201d\u4e2d\u91ab\u8a8d\u70ba\u300c\u813e\u300d\u4e3b\u808c\u8089\uff0c\u80fd\u8f49\u904b\u98df\u7269\u4e2d\u7684\u71df\u990a\u53ca\u6d88\u5316\uff0c\u4ee5\u6ecb\u990a\u5168\u8eab\uff0c\u82e5\u771f\u967d\u4e0d\u8db3\u3001\u813e\u5931\u5065\u904b\uff0c\u5247\u8eab\u9ad4\u904b\u5316\u529f\u80fd\u5931\u5e38\uff0c\u6613\u8b8a\u6210\u75f0\u6fd5(\u8102\u80aa)\u7a4d\u5b58\u65bc\u808c\u819a\u4e2d\uff0c\u5f62\u6210\u80a5\u80d6\u3002<\/p>\n\n\n\n

\u9ad8\u8840\u8102\u75c7\u662f\u73fe\u4ee3\u793e\u6703\u5e38\u898b\u7684\u4ee3\u8b1d\u6027\u75be\u75c5\uff0c\u662f\u5c0e\u81f4\u51a0\u72c0\u52d5\u8108\u75be\u75c5\u53ca\u8166\u8840\u7ba1\u75be\u75c5\u7684\u91cd\u8981\u56e0\u7d20\u4e4b\u4e00\u3002<\/p>\n\n\n\n

\u9810\u9632\u52dd\u65bc\u6cbb\u7642<\/strong><\/p>\n\n\n\n

\u6839\u64da\u570b\u5065\u7f72\u5c0d\u9810\u9632\u9ad8\u8840\u8102\u7684\u5efa\u8b70\u70ba\uff1a\u5b9a\u671f\u5065\u6aa2\u3001\u98f2\u98df\u5747\u8861\u3001\u9069\u5ea6\u904b\u52d5\u3001\u6212\u9664\u83f8\u9152\u7b49\u826f\u597d\u4e4b\u751f\u6d3b\u7fd2\u6163\u3002<\/p>\n\n\n\n

\u4e2d\u91ab\u65b0\u85e5-\u5929\u7136\u964d\u8840\u8102\u88fd\u5291<\/strong><\/p>\n\n\n\n

\u300c\u58fd\u7f8e\u964d\u8102\u4e00\u865f\u81a0\u56ca\u300d\u662f\u570b\u5167\u7b2c\u4e00\u500b\u901a\u904e\u81e8\u5e8a\u8a66\u9a57\u6838\u53ef\u4e0a\u5e02\u7684\u4e2d\u85e5\u65b0\u85e5\uff0c\u5176\u4f86\u6e90\u662f\u5929\u7136Monascus purpureus Went\u83cc\u682a\uff0c\u4e5f\u5c31\u662f\u81fa\u7063\u6c11\u9593\u7528\u4f86\u91c0\u9152\u6216\u88fd\u4f5c\u7d05\u7cdf\u8089\u7684\u7d05\u9eb4\uff0c\u64da\u300a\u672c\u8349\u7db1\u76ee\u300b\u8a18\u8f09\u300c\u7d05\u9eb4\u4e3b\u6cbb\u6d88\u98df\u6d3b\u8840\u3001\u5065\u813e\u71e5\u80c3\u3001\u6cbb\u8d64\u767d\u75e2\u3001\u4e0b\u6c34\u7a40\u300d\u3002<\/p>\n\n\n\n

\u6b64\u83cc\u682a\u7d93\u8403\u53d6\u5f8c\u7684\u6709\u6548\u6210\u5206\u8ddf\u964d\u8840\u8102\u897f\u85e5Lovastatin\u5177\u6709\u76f8\u540c\u7684\u7d50\u69cb\u548c\u6548\u679c\u3002\u6839\u64da\u570b\u5167\u9032\u884c\u4e4b\u96a8\u6a5f\u96d9\u76f2\u7684\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\uff0c\u8b49\u5be6\u300c\u58fd\u7f8e\u964d\u8102\u4e00\u865f\u81a0\u56ca\u300d\u80fd\u986f\u8457\u5730\u964d\u4f4e\u7e3d\u81bd\u56fa\u9187\u53ca\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u3002<\/p>\n\n\n\n

\u7531\u65bc\u9ad4\u5167\u8102\u80aa\u4ee3\u8b1d\u7570\u5e38\u5bb9\u6613\u5f15\u767c\u7d44\u7e54\u7d30\u80de\u4e4b\u6162\u6027\u50b7\u5bb3\uff0c\u53ca\u65e9\u63a7\u5236\u8840\u8102\u53ef\u9810\u9632\u591a\u7a2e\u6162\u6027\u75be\u75c5\u3002<\/p>\n\n\n\n

\u6545\u4f7f\u7528\u6642\u61c9\u6ce8\u610fLovastatin\u53ef\u80fd\u767c\u751f\u7684\u4e0d\u826f\u53cd\u61c9(\u88681)\uff0c\u5118\u91cf\u4e0d\u4f75\u7528\u53ef\u80fd\u6703\u8207Lovastatin\u7522\u751f\u4ea4\u4e92\u4f5c\u7528\u4e4b\u85e5\u54c1(\u88682)\u548c\u5176\u4ed6HMG-CoA\u9084\u539f\u9176\u6291\u5236\u5291\uff0c\u4ea6\u4e0d\u8981\u559d\u8461\u8404\u67da\u6c41\u6216\u5403\u8461\u8404\u67da\uff0c\u4ee5\u514d\u5f71\u97ff\u85e5\u7269\u4ee3\u8b1d\u3002<\/p>\n\n\n\n

\u88681\u3001Lovastatin\u53ef\u80fd\u767c\u751f\u7684\u4e0d\u826f\u53cd\u61c9<\/p>\n\n\n\n
\n \u767c\u751f\u6a5f\u7387<\/strong>\n <\/td>\n \u75c7\u72c0<\/strong>\n <\/td><\/tr>
\n >1%<\/strong>\n <\/td>\n \u8870\u5f31\u3001\u8179\u75db\u3001\u4fbf\u79d8\u3001\u8179\u7009\u3001\u6d88\u5316\u4e0d\u826f\u3001\u8139\u6c23\u3001\u5641\u5fc3\u3001\u808c\u75db\u3001\u982d\u6688\u3001\u982d\u75db\u3001\u76ae\u75b9\u3001\u8996\u529b\u6a21\u7cca\u3002\n <\/td><\/tr>
\n 0.5~1%<\/strong>\n <\/td>\n \u80f8\u75db\u3001\u80c3\u9178\u9006\u6d41\u3001\u53e3\u4e7e\u3001\u5614\u5410\u3001\u8173\u75db\u3001\u80a9\u75db\u3001\u95dc\u7bc0\u75db\u3001\u5931\u7720\u3001\u611f\u89ba\u7570\u5e38\u3001\u79bf\u982d\u3001\u7662\u3001\u773c\u775b\u7570\u5e38\u654f\u611f\u3002\n <\/td><\/tr><\/tbody><\/table>\n\n\n\n

\u88682\u3001\u53ef\u80fd\u6703\u8207Lovastatin\u7522\u751f\u4ea4\u4e92\u4f5c\u7528\u4e4b\u85e5\u54c1<\/p>\n\n\n\n
\u589e\u52a0\u808c\u8089\u526f\u4f5c\u7528\u98a8\u96aa<\/strong> <\/td><\/tr>
\n Statin\u985e\u85e5\u7269\u3001gemfibrozil\u53ca\u5176\u4ed6fibrate\u985e\u85e5\u7269\u3001niacin(>1gm\/\u5929)\u3001cyclosporine\u3001traconazole\u3001ketoconazole\u3001erythromycin\u3001clairthromycin\u3001nefazodone\u3001coumarin\u3001\u5176\u5b83\u6291\u5236cytochromeP450\u4e4b\u85e5\u7269\n <\/td><\/tr><\/tbody><\/table>\n\n\n\n

\u58fd\u7f8e\u964d\u8102\u4e00\u865f\u7c89\u672b\u7d93\u5206\u6790\uff0c\u9664\u964d\u4f4e\u8840\u8102\u80aa\u7684\u4f5c\u7528\u4f86\u81ea\u65bc\u6240\u542b\u70f4\u7532\u57fa\u620a\u4e8c\u917c\u8f14\u9176A(HMG-CoA)\u9084\u539f\u9176\u6291\u5236\u5291\u7684\u6210\u5206(statins)\uff0c\u70ba\u81bd\u56fa\u9187\u5408\u6210\u6291\u5236\u5291\uff0c\u53ef\u964d\u4f4e\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d(LDL)\uff0c\u63d0\u5347\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d(HDL)\uff0c\u9810\u9632\u5fc3\u8840\u7ba1\u75be\u75c5\uff1b\u53e6\u542b\u6709\u5176\u4ed6\u5929\u7136\u6210\u5206\uff1a<\/p>\n\n\n\n

\u5929\u7136\u80fa\u57fa\u9178<\/strong>(\u03b3-GABA)<\/strong> <\/p>\n\n\n\n

 \u6291\u5236\u6027\u795e\u7d93\u50b3\u905e\u7269\u8cea\uff0c\u53c3\u8207\u591a\u7a2e\u4ee3\u8b1d\u6d3b\u52d5\uff0c\u76f4\u63a5\u8abf\u63a7\u808c\u8089\u5f35\u529b\u3002\u4e3b\u8981\u5b58\u5728\u4eba\u9ad4\u7684\u8166\u90e8\uff0c\u5177\u6709\u8a31\u591a\u751f\u7406\u529f\u6548\uff1a(1)\u7a69\u5b9a\u8840\u58d3\uff0c\u4f7f\u8840\u7ba1\u64f4\u5f35\u53ca\u6291\u5236\u8840\u7ba1\u5f35\u529b\u7d20\u7684\u6d3b\u6027\u9054\u5230\u964d\u4f4e\u8840\u58d3\u7684\u4f5c\u7528\u3001(2)\u5e6b\u52a9\u7761\u7720\uff0c\u589e\u52a0\u975e\u5feb\u901f\u52d5\u773c\u7761\u7720\u7684\u7b2c\u4e09\u3001\u56db\u671f\u7761\u7720\u968e\u6bb5\u53ca\u6291\u5236\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u904e\u5ea6\u8208\u596e\uff0c\u5c0d\u8166\u90e8\u5177\u6709\u5b89\u5b9a\u7684\u4f5c\u7528\uff0c\u9032\u800c\u4fc3\u9032\u653e\u9b06\u3001(3)\u6297\u7126\u616e\uff0c\u5728GABAA<\/sub>\u7684\u5b58\u5728\u4e0b\u6e1b\u7de9\u795e\u7d93\u6d3b\u52d5\u7684\u6548\u679c\uff0c\u6d88\u9664\u795e\u7d93\u7dca\u5f35\u3002<\/p>\n\n\n\n

\u690d\u7269\u56fa\u9187<\/strong>(Ergosterol)<\/strong><\/p>\n\n\n\n

 \u6e90\u65bc\u690d\u7269\uff0c\u4eba\u9ad4\u7121\u6cd5\u81ea\u884c\u5408\u6210\uff0c\u4e0d\u7d93\u8178\u80c3\u9053\u5438\u6536\uff0c\u5bb9\u6613\u7531\u81bd\u6c41\u6392\u51fa\uff0c\u6240\u4ee5\u4e0d\u5bb9\u6613\u84c4\u7a4d\u9ad4\u5167\uff1b\u5e72\u64fe\u8178\u9053\u5438\u6536\u81bd\u56fa\u9187\uff0c\u56e0\u6b64\u91dd\u5c0d\u6709\u51a0\u5fc3\u75c7\u53c8\u5408\u4f75\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u75c5\u60a3\uff0c\u5efa\u8b70\u6bcf\u65e5\u61c9\u651d\u53d6\u4e8c\u81f3\u4e09\u516c\u514b\u7684\u690d\u7269\u56fa\u9187\uff0c\u4ee5\u6e1b\u5c11\u81bd\u56fa\u9187\u7684\u5438\u6536\uff0c\u9054\u5230\u4fdd\u8b77\u5fc3\u8840\u7ba1\u7684\u529f\u7528\u3002<\/p>\n\n\n\n

\u7570\u9ec3\u916e<\/strong>\uff08<\/strong>Isoflavones<\/strong>\uff09<\/strong><\/strong><\/p>\n\n\n\n

 \u7570\u9ec3\u916e\u662f\u4e00\u7a2e\u985e\u4f3c\u8377\u723e\u8499\u822c\u7684\u5316\u5408\u7269\uff0c\u53c8\u53eb\u505a\u690d\u7269\u6027\u96cc\u6fc0\u7d20(Phytoestrogen)\u3002\u5b83\u5011\u7684\u5316\u5b78\u7d50\u69cb\u8207\u5973\u6027\u52d5\u60c5\u6fc0\u7d20\u7684\u69cb\u9020\u8207\u529f\u80fd\u76f8\u8fd1\uff0c\u53ef\u4ee5\u964d\u4f4e\u8840\u4e2d\u81bd\u56fa\u9187\uff0c\u4e26\u4e14\u80fd\u7de9\u89e3\u5973\u6027\u66f4\u5e74\u671f\u505c\u7d93\u5f8c\u7684\u4e0d\u9069\u75c7\u72c0\uff0c\u53ef\u6291\u5236\u56e0\u8377\u723e\u8499\u5931\u8abf\u6240\u5f15\u767c\u7684\u816b\u7624\u7d30\u80de\u7684\u751f\u9577\uff0c\u8a31\u591a\u7814\u7a76\u6307\u51fa\u7570\u9ec3\u916e\u53ef\u4ee5\u964d\u4f4e\u5973\u6027\u7f79\u60a3\u76f8\u95dc\u75be\u75c5\u7684\u6a5f\u7387\uff0c\u4e26\u5229\u7528\u7570\u9ec3\u916e\u4f86\u9810\u9632\u7d93\u524d\u75c7\u5019\u7fa4\uff08PMS\uff09\u3001\u66f4\u5e74\u671f\u548c\u4e73\u764c\u6240\u5f15\u8d77\u7684\u4e00\u4e9b\u4e0d\u9069\u61c9\u75c7\u72c0\u3002<\/p>\n\n\n\n

\u4e0d\u98fd\u548c\u8102\u80aa\u9178<\/strong>(Unsaturated fatty acid)<\/strong><\/p>\n\n\n\n

\u4e0d\u98fd\u548c\u8102\u80aa\u9178\u4e3b\u8981\u5206\u6210\u5169\u7fa4\uff1aomega-3\u548comega-6\u8102\u80aa\u9178\u3002\u73fe\u4ee3\u98f2\u98df\u5bb9\u6613\u7f3a\u4e4fomega-3\uff0c\u7531\u65bc\u4eba\u9ad4\u7121\u6cd5\u85c9\u7531\u9175\u7d20\u4f5c\u7528\u5c07\u96d9\u9375\u52a0\u5165\u5728omega-3\u548comega-6\u7684\u4f4d\u5b50\uff0c\u5167\u542b\u4e9e\u9ebb\u6cb9\u9178(linoleic acid)\u548c\u6b21\u4e9e\u9ebb\u6cb9\u9178(\u03b1-linolenicacid)\u70ba\u5fc5\u9808\u7684\u71df\u990a\u6210\u4efd\u3002\u8db3\u91cf\u651d\u53d6\u53ef\u4ee5\u4fdd\u8b77\u8840\u7ba1\uff0c\u6e1b\u5c11\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u3001\u764c\u75c7\uff0c\u4e5f\u53ef\u5e6b\u52a9\u8166\u90e8\u767c\u80b2\u3002<\/p>\n\n\n\n

\u4ec0\u9ebc\u4eba\u9069\u5408\u670d\u7528\u58fd\u7f8e\u964d\u8102\u4e00\u865f\u5462?<\/strong><\/p>\n\n\n\n

\u81e8\u5e8a\u4e0a\u5e38\u7528\u65bc\uff1a<\/strong><\/p>\n\n\n\n

  • \u8f15\u3001\u4e2d\u5ea6\u9ad8\u81bd\u56fa\u9187\u60a3\u8005\u3002<\/li>
  • \u6cbb\u7642\u4ee5\u9ad8\u81bd\u56fa\u9187\u70ba\u4e3b\u7684\u6df7\u5408\u6027\u8840\u8102\u7570\u5e38\u3002<\/li>
  • \u8f15\u5ea6TG\u5347\u9ad8\u53ca\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\u964d\u4f4e\u7684\u60a3\u8005\u3002<\/li>
  • \u51a0\u5fc3\u75c5\u7684\u6b21\u7d1a\u9810\u9632\u3001\u8840\u8102\u6c34\u6e96\u908a\u7de3\u578b\u7684\u51a0\u5fc3\u75c5\u60a3\u8005\u3002<\/li>
  • \u8166\u4e2d\u98a8\u3001\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u58d3\u3001\u814e\u81df\u75c5\uff0c\u4ee3\u8b1d\u75c7\u5019\u7fa4\u53ca\u8001\u5e74\u8840\u8102\u7570\u5e38\u3002<\/li>
  • \u5176\u4ed6Statins\u985e\u897f\u85e5\u85e5\u7269\u4e0d\u8010\u53d7\u6216\u5f15\u8d77\u809d\u9176\u548c\u808c\u9176\u5347\u9ad8\u60a3\u8005\u3002<\/li>
  • \u9810\u9632\u8102\u80aa\u809d\u60e1\u5316\u3002<\/li>
  • \u505c\u7d93\u5f8c\u5a66\u5973\u3002<\/li><\/ul>\n\n\n\n

    \u7d05\u9eb4\u85e5\u54c1\u4e4b\u5b89\u5168\u6027\u6ce8\u610f\u4e8b\u9805\uff1a<\/strong><\/p>\n\n\n\n

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