{"id":9420,"date":"2020-07-15T10:27:31","date_gmt":"2020-07-15T02:27:31","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/csh\/?p=9420"},"modified":"2024-11-13T11:35:04","modified_gmt":"2024-11-13T03:35:04","slug":"%e8%86%80%e8%83%b1%e5%85%a7%e7%81%8c%e6%b3%a8azacitidine%e9%80%9a%e9%81%8e-tnf-r1-%e5%92%8c-trail-r2-%e4%bf%a1%e8%99%9f%e6%8a%91%e5%88%b6%e5%9f%ba%e5%9b%a0%e6%af%92%e6%80%a7%e8%87%b4%e7%99%8c%e7%89%a9","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/csh\/?p=9420","title":{"rendered":"\u8180\u80f1\u5167\u704c\u6ce8Azacitidine\u901a\u904e TNF-R1 \u548c TRAIL-R2 \u4fe1\u865f\u6291\u5236\u57fa\u56e0\u6bd2\u6027\u81f4\u764c\u7269\u8a98\u5c0e\u7684\u8180\u80f1\u816b\u7624"},"content":{"rendered":"<p>Azacitidine\u662f\u4e00\u7a2e DNA \u7532\u57fa\u5316\u6291\u88fd\u5291\uff0c\u53ef\u900f\u904e\u8a98\u5c0e\u7d30\u80de\u51cb\u4ea1\u548c\u6291\u5236\u816b\u7624\u7d30\u80de\u589e\u6b96\u5c55\u73fe\u5176\u5c0d\u591a\u7a2e\u60e1\u6027\u816b\u7624\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u7136\u800c\uff0c\u76ee\u524d\u9bae\u5c11\u7814\u7a76\u91dd\u5c0dAzacitidine\u65bc\u8180\u80f1\u5c3f\u8def\u4e0a\u76ae\u764c (UBUC) \u7684\u6297\u816b\u7624\u7642\u6548\u52a0\u4ee5\u63a2\u8a0e\uff0c\u5c24\u5176\u662f\u900f\u904e\u8180\u80f1\u5167\u704c\u6ce8 (IVI) \u9032\u884c\u6cbb\u7642\u4e00\u4e8b\u3002\u6211\u5011\u5229\u7528UBUC \u7d30\u80de\u682a\u5be6\u9a57\u5206\u6790Azacitidine\u7684\u6cbb\u7642\u7642\u6548\uff0c\u4e26\u900f\u904eantibody array\u548cwestern blotting\u63a2\u7a76\u5176\u6f5b\u5728\u4fe1\u865f\u50b3\u905e\u8def\u5f91\uff0c\u6700\u5f8c\u4ee5N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) \u8a98\u767c\u4e4bUBUC \u52d5\u7269\u6a21\u578b\u6e2c\u5b9a\u5927\u9f20\u816b\u7624\u751f\u9577\u60c5\u5f62\u3002<\/p>\n<p>\u9ad4\u5916\u8a66\u9a57\u7d50\u679c\u986f\u793a\uff0cAzacitidine \u986f\u8457\u6291\u5236 UBUC \u7d30\u80de\u682a\u4e2d\u7684 DNMT \u8868\u73fe\u91cf\u3001\u7d30\u80de\u5b58\u6d3b\u7387\u548c\u7fa4\u805a\u5f62\u6210\u80fd\u529b\uff0c\u540c\u6642\u589e\u52a0sub-G1\u671f\u7d30\u80de\u548cAnnexin V-PI+ \u7d30\u80de\u7fa4\u5f15\u767c\u7d30\u80de\u6bd2\u6027\u3002Antibody array\u8b49\u5be6Azacitidine\u53ef\u900f\u904e\u6291\u5236 TNF-R1\u8def\u5f91\u548c\u8a98\u5c0e TRAIL-R2\u8def\u5f91\u6d3b\u5316\u9032\u800c\u5f71\u97ff\u53ca\u5176\u4e0b\u6e38\u4fe1\u865f\u5206\u5b50\u8868\u73fe\uff0c\u5305\u62ec\u53d7TNF-R1\u4e0b\u8abf\u5f71\u97ff\u4e4bclaspin \u548csurvivin\u8868\u73fe\u91cf\u4e0b\u964d\uff0c\u4ee5\u53ca\u53d7 TRAIL-R2 \u6fc0\u6d3b\u800c\u63d0\u5347cytochrome C \u548c caspase-3 \u7684\u8868\u73fe\u91cf\u3002<\/p>\n<p>\u9ad4\u5167\u8a66\u9a57\u7d50\u679c\u986f\u793a\u7d93\u7531IVI\u7d66\u4e88Azacitidine\u5f8c\uff0c\u53ef\u986f\u8457\u964d\u4f4e\u7d93BBN \u8a98\u5c0e\u8180\u80f1\u764c\u5927\u9f20\u7684\u816b\u7624\u8ca0\u8377\u548c Ki67 index\u3002\u6211\u5011\u9a57\u8b49\u4e86\u7d93\u7531\u8180\u80f1\u704c\u6ce8Azacitidine\u53ef\u900f\u904e\u6539\u8b8a TRAIL-R2 \u548c TNF-R1 \u8a0a\u865f\u8def\u5f91\u6e1b\u7de9 BBN \u8a98\u5c0e\u7684\u8180\u80f1\u764c\u9032\u5c55\uff0c\u671f\u8a31\u5176\u53ef\u70ba\u9032\u4e00\u6b65\u7684\u81e8\u5e8a\u8a66\u9a57\u63d0\u4f9b\u65b0\u7684\u898b\u89e3\u3002<\/p>\n<p><!--more--><\/p>\n<p><a href=\"https:\/\/web.csh.org.tw\/web\/csh\/wp-content\/uploads\/2020\/07\/2022-8.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-24597\" src=\"https:\/\/web.csh.org.tw\/web\/csh\/wp-content\/uploads\/2020\/07\/2022-8.jpg\" alt=\"\" width=\"720\" height=\"960\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Azacitidine\u662f\u4e00\u7a2e DNA \u7532\u57fa\u5316\u6291\u88fd\u5291\uff0c\u53ef\u900f\u904e\u8a98\u5c0e\u7d30\u80de\u51cb\u4ea1\u548c\u6291\u5236\u816b\u7624\u7d30\u80de\u589e\u6b96\u5c55\u73fe\u5176\u5c0d\u591a\u7a2e\u60e1\u6027\u816b\u7624\u7684 [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-9420","post","type-post","status-publish","format-standard","hentry","category-4"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/9420"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9420"}],"version-history":[{"count":2,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/9420\/revisions"}],"predecessor-version":[{"id":24598,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/9420\/revisions\/24598"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9420"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9420"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}