{"id":9385,"date":"2020-07-15T09:18:27","date_gmt":"2020-07-15T01:18:27","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/csh\/?p=9385"},"modified":"2024-11-13T11:35:47","modified_gmt":"2024-11-13T03:35:47","slug":"%e5%8f%b0%e7%81%a3%e8%82%ba%e8%85%ba%e7%99%8c%e6%82%a3%e8%80%85%e5%9b%a0%e6%ac%a1%e7%99%bc%e5%9e%8b%e8%a1%a8%e7%9a%ae%e7%94%9f%e9%95%b7%e5%9b%a0%e5%ad%90%e5%8f%97%e9%ab%94egfrt790m%e7%aa%81%e8%ae%8a","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/csh\/?p=9385","title":{"rendered":"\u53f0\u7063\u80ba\u817a\u764c\u60a3\u8005\u56e0\u6b21\u767c\u578b\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4(EGFR)T790M\u7a81\u8b8a\u5c0e\u81f4\u7684\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4-\u916a\u80fa\u9178\u9176\u6291\u5236\u5291(EGFR-TKI)\u6297\u85e5\u6027\u7684\u89c0\u5bdf\u6027\u7814\u7a76"},"content":{"rendered":"<p><strong>1.<\/strong><strong>\u7814\u7a76\u7d50\u679c\uff1a<\/strong><\/p>\n<p>2013 \u5e74 6 \u6708\u81f3 2018 \u5e74 12 \u6708\u5728\u53f0\u7063\u4e03\u5bb6\u91ab\u7642\u4e2d\u5fc3\u9032\u884c\u7684\u6aa2\u6e2c\u3002\u6392\u9664\u4e86 de novo T790M \u6216\u4f7f\u7528\u4e00\u7a2e\u4ee5\u4e0a EGFR-TKI \u7684\u60a3\u8005\u3002\u5171407\u4f8b\u60a3\u8005\uff0c\u7e3d\u9ad4T790M\u7372\u5f97\u7387\u70ba52.8%\u3002\u60a3\u8005gefitinib, erlotinib, and afatinib\u6cbb\u7642\u7d44\u5728\u75be\u75c5\u9032\u5c55\u5f8c\u7684 T790M \u7387\uff08\u5206\u5225\u70ba 59.9\u300145.5 \u548c 52.7%\uff1bp = 0.037\uff09\u3002\u5177\u6709\u5e38\u898bEGFR\u7a81\u8b8a\uff08Del-19 \u548c L858R\uff09\uff08p = 0.005\uff09\u548cEGFR-TKI \u6cbb\u7642\u6301\u7e8c\u6642\u9593\u8d8a\u9577\uff08p &lt; 0.001\uff09\uff0cT790M \u7684\u7372\u5f97\u6a5f\u7387\u8d8a\u9ad8\u3002\u591a\u56e0\u7d20Logistic\u56de\u6b78\u5206\u6790\u9032\u4e00\u6b65\u8868\u660e\uff0c\u5e38\u898b\u7684EGFR \u7a81\u8b8a\u3001gefitinib\uff08\u8207erlotinib\u76f8\u6bd4\uff09\u7d66\u85e5\uff0c\u4ee5\u53caEGFR-TKI \u6cbb\u7642\u6642\u9593\u8d8a\u9577\uff0cT790M \u767c\u751f\u7387\u8d8a\u9ad8\u3002<\/p>\n<p><strong>\u00a0<\/strong><strong>2.<\/strong><strong>\u7814\u7a76\u8ca2\u737b\u8207\u81e8\u5e8a\u61c9\u7528\uff1a<\/strong><\/p>\n<p>\u9019\u9805\u7814\u7a76\u8868\u660e\uff0c\u63a5\u53d7gefitinib\u6cbb\u7642\u7684\u60a3\u8005\uff0c\u651c\u5e36\u5e38\u898b\u7684 EGFR \u7a81\u8b8a\uff0cEGFR-TKI\u6cbb\u7642\u6642\u9593\u9577\u7684\u60a3\u8005\uff0c\u589e\u52a0\u4e86 T790M \u7372\u5f97\u7684\u767c\u751f\u7387\uff0c\u7136\u800c\u9019\u4e9b\u75c5\u4eba\u9069\u7528\u65bc\u5f8c\u7e8c\u63a5\u53d7osimertinib\u6cbb\u7642\u7684\u6a5f\u6703\u3002<\/p>\n<p><!--more--><\/p>\n<p><strong><a href=\"https:\/\/web.csh.org.tw\/web\/csh\/wp-content\/uploads\/2020\/07\/2021-6.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-24577\" src=\"https:\/\/web.csh.org.tw\/web\/csh\/wp-content\/uploads\/2020\/07\/2021-6.jpg\" alt=\"\" width=\"720\" height=\"960\" \/><\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1.\u7814\u7a76\u7d50\u679c\uff1a 2013 \u5e74 6 \u6708\u81f3 2018 \u5e74 12 \u6708\u5728\u53f0\u7063\u4e03\u5bb6\u91ab\u7642\u4e2d\u5fc3\u9032\u884c\u7684\u6aa2\u6e2c\u3002\u6392\u9664\u4e86 de no [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-9385","post","type-post","status-publish","format-standard","hentry","category-4"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/9385"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9385"}],"version-history":[{"count":3,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/9385\/revisions"}],"predecessor-version":[{"id":24578,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/9385\/revisions\/24578"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9385"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9385"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9385"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}