{"id":9292,"date":"2020-07-14T11:03:47","date_gmt":"2020-07-14T03:03:47","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/csh\/?p=9292"},"modified":"2024-11-13T11:37:05","modified_gmt":"2024-11-13T03:37:05","slug":"%e6%8e%a2%e8%a8%8etimp3-%e5%95%9f%e5%8b%95%e5%ad%90%e7%94%b2%e5%9f%ba%e5%8c%96%e8%88%87%e5%8f%a3%e8%85%94%e7%99%8c%e8%bd%89%e7%a7%bb%e4%b9%8b%e7%9b%b8%e9%97%9c%e6%80%a7","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/csh\/?p=9292","title":{"rendered":"\u63a2\u8a0eTIMP3 \u555f\u52d5\u5b50\u7532\u57fa\u5316\u8207\u53e3\u8154\u764c\u8f49\u79fb\u4e4b\u76f8\u95dc\u6027"},"content":{"rendered":"<p><strong>1.<\/strong><strong>\u7814\u7a76\u7d50\u679c\uff1a<\/strong><\/p>\n<p>\u9996\u5148\u5229\u7528 pyrosequencing \u8b49\u5be6\u5728\u53e3\u8154\u764c\u7d30\u80de\u682a\u4e2d\uff0cTIMP3 \u555f\u52d5\u5b50 CpG island \u7684\u7532\u57fa\u5316\u7a0b\u5ea6\u6bd4\u6b63\u5e38\u53e3\u8154\u7d30\u80de\u9ad8\uff0c\u4e14 CpG island \u7684\u7532\u57fa\u5316\u6703\u5f71\u97ff\u8f49\u9304\u56e0\u5b50 Sp1 \u8207 TIMP3 \u555f\u52d5\u5b50\u7d50\u5408\u800c\u6291\u5236 TIMP3 \u7684\u8868\u73fe\u3002\u6211\u5011\u4e5f\u8b49\u5be6 TIMP3 \u7684\u8868\u73fe\u4e3b\u8981\u662f\u53d7\u5230\u7532\u57fa\u8f49\u79fb\u9176 (DNA methyltransferase; DNMT) DNMT1 \u8207 DNMT3B \u7684\u8abf\u63a7\u3002\u9032\u4e00\u6b65\u5c07 TIMP3 \u5728\u53e3\u8154\u764c\u7d30\u80de\u4e2d\u5927\u91cf\u8868\u73fe\uff0c\u767c\u73fe\u5728\u53e3\u8154\u764c\u7d30\u80de\u8207\u52d5\u7269\u6a21\u5f0f\u4e2d\uff0c\u80fd\u6291\u5236\u7d30\u80de\u722c\u884c\u3001\u4fb5\u8972\u53ca\u8f49\u79fb\u7684\u80fd\u529b\u3002\u6b64\u5916\uff0cTIMP3 \u80fd\u4fc3\u9032\u4e0a\u76ae\u578b\u614b\u5206\u5b50 E-cadherin \u8207 ZO-1 \u7684\u8868\u73fe\uff0c\u4e26\u6291\u5236\u9593\u8cea\u578b\u614b\u5206\u5b50 Snail\u3001Twist\u3001vimentin \u53ca fibronectin \u7684\u8868\u73fe\uff0c\u4f86\u6291\u5236\u53e3\u8154\u764c\u7d30\u80de\u7684\u4e0a\u76ae\u9593\u8cea\u578b\u614b\u8f49\u63db (Epithelial-mesenchymal transition; EMT)\u3002<\/p>\n<p><strong>2.\u7814\u7a76\u8ca2\u737b\u8207\u81e8\u5e8a\u61c9\u7528\uff1a<\/strong><\/p>\n<p>\u7d9c\u5408\u4ee5\u4e0a\u7d50\u679c\uff0c\u6211\u5011\u8b49\u5be6 TIMP3 \u7532\u57fa\u5316\u6291\u5236 TIMP3 \u7684\u8868\u73fe\u6703\u5c0e\u81f4\u53e3\u8154\u764c\u7d30\u80de\u7684\u8f49\u79fb\u3002<!--more--><\/p>\n<p><strong><a href=\"https:\/\/web.csh.org.tw\/web\/csh\/wp-content\/uploads\/2020\/07\/2019-14.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-24541\" src=\"https:\/\/web.csh.org.tw\/web\/csh\/wp-content\/uploads\/2020\/07\/2019-14.jpg\" alt=\"\" width=\"720\" height=\"960\" \/><\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1.\u7814\u7a76\u7d50\u679c\uff1a \u9996\u5148\u5229\u7528 pyrosequencing \u8b49\u5be6\u5728\u53e3\u8154\u764c\u7d30\u80de\u682a\u4e2d\uff0cTIMP3 \u555f\u52d5\u5b50 CpG is [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-9292","post","type-post","status-publish","format-standard","hentry","category-4"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/9292"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9292"}],"version-history":[{"count":4,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/9292\/revisions"}],"predecessor-version":[{"id":24542,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/9292\/revisions\/24542"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}