{"id":5354,"date":"2018-05-23T16:05:39","date_gmt":"2018-05-23T08:05:39","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/csh\/?p=5354"},"modified":"2018-05-23T16:05:39","modified_gmt":"2018-05-23T08:05:39","slug":"%e7%a0%94%e7%a9%b6%e7%84%a6%e9%bb%9e-11","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/csh\/?p=5354","title":{"rendered":"\u7814\u7a76\u7126\u9ede"},"content":{"rendered":"<p><strong>\u8ad6\u6587\u540d\u7a31<\/strong><\/p>\n<p><strong>\u4e2d\u6587\uff1aCantharidic acid\u8a98\u5c0e\u8840\u764c\u7d30\u80de\u51cb\u4ea1\u7684\u6a5f\u5236\u63a2\u8a0e<\/strong><\/p>\n<p><strong>\u82f1\u6587\uff1aCantharidic acid induces apoptosis of human leukemic HL-60 cells via c-Jun N-terminal kinase-regulated caspase-8\/-9\/-3 activation pathway.<\/strong><\/p>\n<p><strong>\u4f5c\u8005\uff1a\u81e8\u5e8a\u7814\u7a76\u4e2d\u5fc3\u00a0 \u694a\u9806\u767c \u4e3b\u4efb<\/strong><\/p>\n<p>&nbsp;<\/p>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td width=\"557\"><strong>\u672c\u7bc7\u8ad6\u6587\u767c\u8868\u65bcWorld Journal of Gastroenterology<\/strong><strong>\u671f\u520a<\/strong><strong>\u00a02017 November 28; 23(44): 7881-7887<\/strong><a href=\"https:\/\/web.csh.org.tw\/web\/csh\/wp-content\/uploads\/2018\/02\/15.pdf\"><strong>\u5168\u6587\u4e0b\u8f09<\/strong><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u7814\u7a76\u76ee\u7684\uff1a<\/strong><\/p>\n<p>\u767d\u8840\u75c5\uff0c\u4fd7\u7a31\u8840\u764c (Leukemia)\uff0c\u662f\u6307\u4eba\u9ad4\u7684\u4e3b\u8981\u9020\u8840\u7cfb\u7d71&#8211;\u9aa8\u9ad3\u7522\u751f\u4e86\u764c\u5316\u75c5\u8b8a\uff0c\u56e0\u4e0d\u6210\u719f\u7684\u767d\u8840\u7403\u7121\u6cd5\u9032\u884c\u6b63\u5e38\u4e4b\u5206\u5316\u800c\u7570\u5e38\u589e\u751f\uff0c\u5c0e\u81f4\u60e1\u6027\u764c\u75c7\u7684\u5f62\u6210\u3002\u4f46\u662f\u6591\u87ab\u7d20\u5176\u884d\u751f\u7269(Cantharidic acid)\u5c0d\u8a98\u5c0e\u8840\u764c\u7d30\u80deapoptosis\u7684\u8a73\u7d30\u8def\u5f91\u65b9\u9762\u7684\u7814\u7a76\uff0c\u5247\u5c1a\u672a\u660e\u77ad\u3002<\/p>\n<p><strong>\u7814\u7a76\u7d50\u679c\uff1a<\/strong><\/p>\n<p>\u672c\u5be6\u9a57\u5ba4\u5229\u7528cantharidic acid\u8655\u7406\u8840\u764c\u7d30\u80de (HL-60 cell lines)\uff0c\u767c\u73fecantharidic acid\u53ef\u6709\u6548\u964d\u4f4e\u5176\u7d30\u80de\u5b58\u6d3b\u7387\uff0c\u6211\u5011\u4e5f\u5229\u7528flow cytometer\u5206\u6790\u65b9\u5f0f\u767c\u73fecantharidic acid\u5177\u6709\u8a98\u5c0eHL-60\u6b64\u8840\u764c\u7d30\u80de\u51cb\u4ea1\u7684\u80fd\u529b\u53ca\u5f71\u97ff\u7d30\u80de\u9031\u671f\u3002\u6211\u5011\u521d\u6b65\u4e5f\u767c\u73fecantharidic acid\u5176\u8a98\u5c0e\u51cb\u4ea1\u7684\u8def\u5f91\uff0c\u53ef\u80fd\u8207caspase -3, -8, -9 \u8def\u5f91\u53caPARP\u7684\u6d3b\u5316\u6709\u95dc\u3002<\/p>\n<p><strong>\u7814\u7a76\u8ca2\u737b\u8207\u81e8\u5e8a\u61c9\u7528\uff1a<\/strong><\/p>\n<p>Cantharidic acid\u4e5f\u8a31\u53ef\u4ee5\u4f5c\u70ba\u8840\u764c\u7684\u8f14\u52a9\u6cbb\u7642\u7528\u85e5\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8ad6\u6587\u540d\u7a31 \u4e2d\u6587\uff1aCantharidic acid\u8a98\u5c0e\u8840\u764c\u7d30\u80de\u51cb\u4ea1\u7684\u6a5f\u5236\u63a2\u8a0e \u82f1\u6587\uff1aCantharidic ac [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5354","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/5354"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5354"}],"version-history":[{"count":1,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/5354\/revisions"}],"predecessor-version":[{"id":5355,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/5354\/revisions\/5355"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5354"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5354"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5354"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}