{"id":5351,"date":"2018-05-23T15:58:43","date_gmt":"2018-05-23T07:58:43","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/csh\/?p=5351"},"modified":"2018-05-23T15:58:43","modified_gmt":"2018-05-23T07:58:43","slug":"%e7%a0%94%e7%a9%b6%e7%84%a6%e9%bb%9e-10","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/csh\/?p=5351","title":{"rendered":"\u7814\u7a76\u7126\u9ede"},"content":{"rendered":"<p><strong>\u8ad6\u6587\u540d\u7a31<\/strong><\/p>\n<p><strong>\u4e2d\u6587\uff1aWISP1\u57fa\u56e0\u591a\u578b\u6027\u53ca\u5176\u529f\u80fd\u6027\u8207\u6ccc\u5c3f\u4e0a\u76ae\u764c\u7684\u76f8\u95dc\u6027\u63a2\u8a0e<\/strong><\/p>\n<p><strong>\u82f1\u6587\uff1a<\/strong><strong>\u00a0WISP1 genetic variants as predictors of tumor development with urothelial cell carcinoma.<\/strong><\/p>\n<p><strong>\u4f5c\u8005\uff1a\u6d88\u5316\u5916\u79d1\u00a0 \u674e\u7965\u9e9f \u4e3b\u6cbb\u91ab\u5e2b<\/strong><\/p>\n<p>&nbsp;<\/p>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td width=\"557\"><strong>\u672c\u7bc7\u8ad6\u6587\u767c\u8868\u65bcWorld Journal of Gastroenterology<\/strong><strong>\u671f\u520a<\/strong><strong>\u00a02017 November 28; 23(44): 7881-7887<\/strong><a href=\"https:\/\/web.csh.org.tw\/web\/csh\/wp-content\/uploads\/2018\/02\/15.pdf\"><strong>\u5168\u6587\u4e0b\u8f09<\/strong><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u7814\u7a76\u76ee\u7684\uff1a<\/strong><\/p>\n<p>WNT1-induced Secreted Protein-1 (WISP1)\u86cb\u767d\u8868\u73fe\u8207\u6ccc\u5c3f\u4e0a\u76ae\u764c\u7684\u76f8\u95dc\u6027\u5df2\u6709\u90e8\u5206\u6587\u737b\u767c\u8868\uff0c\u4f46\u662fWISP1\u7684\u57fa\u56e0\u591a\u578b\u6027\u8207\u7f79\u60a3\u6ccc\u5c3f\u4e0a\u76ae\u764c\u7684\u98a8\u96aa\u53ca\u8207\u5176\u81e8\u5e8a\u75c5\u7406\u72c0\u614b\u7684\u76f8\u95dc\u6027\u4ecd\u4e0d\u6e05\u695a\u3002\u56e0\u6b64\uff0c\u672c\u7814\u7a76\u4e4b\u76ee\u7684\u5373\u5229\u7528real time PCR-genotype\u7684\u65b9\u5f0f\uff0c\u91dd\u5c0d738\u4f4d\u7684\u5065\u5eb7\u5c0d\u7167\u7d44\u8207369\u4f4d\u7684\u6ccc\u5c3f\u4e0a\u76ae\u764c\u60a3\u8005\uff0c\u9032\u884c\u9019\u4e9b\u53d7\u6e2c\u8005\u7684WISP1 \u5176rs62514004, rs2977530, rs2977537\u53cars2929973\u4e4b\u57fa\u56e0\u591a\u578b\u6027\u5206\u6790\u3002<\/p>\n<p><strong>\u7814\u7a76\u7d50\u679c\uff1a<\/strong><\/p>\n<p>\u8207\u5065\u5eb7\u5c0d\u7167\u7d44\u7684\u53d7\u8a66\u8005\u6bd4\u5c0d\u5f8c\u767c\u73fe\uff0c\u7d50\u679c\u767c\u73feWISP1 \u5176\u56db\u500b\u57fa\u56e0\u591a\u578b\u6027\u8207\u7f79\u60a3\u6ccc\u5c3f\u4e0a\u76ae\u764c\u7684\u6a5f\u7387\u4e0d\u5177\u7d71\u8a08\u5b78\u4e0a\u7684\u610f\u7fa9\u3002\u800c\u6211\u5011\u66f4\u9032\u4e00\u6b65\u8207\u5176\u81e8\u5e8a\u75c5\u7406\u72c0\u614b\u5206\u6790\uff0c\u7d50\u679c\u767c\u73fe\uff0c\u7576WISP1 \u5176rs2929973\u5176\u57fa\u56e0\u578b\u70baAG or GG\u6642\uff0c\u6703\u4fc3\u4f7f\u6ccc\u5c3f\u4e0a\u76ae\u764c\u8f49\u6210invasive tumor\u7684\u6a5f\u7387(p=0.007)\u3002\u56e0\u6b64\uff0c\u6211\u5011\u53ef\u4ee5\u767c\u73feWISP1\u7684\u57fa\u56e0\u591a\u578b\u6027\uff0c\u5c24\u5176\u662fWISP1 \u5176rs2929973\u5176\u57fa\u56e0\u578b\u70baAG or GG\u6642\uff0c\u53ef\u88ab\u8996\u70ba\u662f\u6ccc\u5c3f\u4e0a\u76ae\u764c\u767c\u5c55\u6709\u95dc\u4e4b\u76f8\u95dc\u56e0\u5b50\u3002<\/p>\n<p><strong>\u7814\u7a76\u8ca2\u737b\u8207\u81e8\u5e8a\u61c9\u7528\uff1a<\/strong><\/p>\n<p>\u5728\u672c\u7814\u7a76\u4e2dWISP1 \u57fa\u56e0\u5c0d\u65bc\u6ccc\u5c3f\u4e0a\u76ae\u764c\u8f49\u6210invasive tumor\u7684\u767c\u751f\u4f3c\u4e4e\u6709\u4e00\u500b\u6f5b\u5728\u4e14\u76f4\u63a5\u7684\u76f8\u95dc\u3002\u7136\u800c\uff0c\u6ccc\u5c3f\u4e0a\u76ae\u764c\u7684\u767c\u751f\u53ef\u80fd\u662f\u7531\u591a\u7a2e\u74b0\u5883\u56e0\u5b50\u5408\u4f75\u751f\u7406\u56e0\u5b50\u6240\u9020\u6210\uff0c\u56e0\u6b64\u5c0d\u65bc\u57fa\u56e0\u5c0d\u764c\u75c7\u76f8\u95dc\u6240\u9020\u6210\u7684\u5f71\u97ff\u53ef\u80fd\u4e5f\u53d7\u5230\u74b0\u5883\u56e0\u5b50\u6240\u8abf\u63a7\uff0c\u800c\u9019\u9700\u8981\u66f4\u5b8c\u6574\u7684\u6d41\u884c\u75c5\u5b78\u8cc7\u6599\u52a0\u4ee5\u5206\u6790\u8a0e\u8ad6\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8ad6\u6587\u540d\u7a31 \u4e2d\u6587\uff1aWISP1\u57fa\u56e0\u591a\u578b\u6027\u53ca\u5176\u529f\u80fd\u6027\u8207\u6ccc\u5c3f\u4e0a\u76ae\u764c\u7684\u76f8\u95dc\u6027\u63a2\u8a0e \u82f1\u6587\uff1a\u00a0WISP1 genetic v [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5351","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/5351"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5351"}],"version-history":[{"count":1,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/5351\/revisions"}],"predecessor-version":[{"id":5352,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/5351\/revisions\/5352"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5351"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5351"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}