{"id":3192,"date":"2017-03-15T13:50:06","date_gmt":"2017-03-15T05:50:06","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/csh\/?p=3192"},"modified":"2024-11-13T11:40:44","modified_gmt":"2024-11-13T03:40:44","slug":"musashi-1-promotes-a-cancer-stem-cell-lineage-and-chemoresistance-in-colorectal-cancer-cells","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/csh\/?p=3192","title":{"rendered":"Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells"},"content":{"rendered":"<p><strong>\u00a0<\/strong><strong>1.<\/strong><strong>\u7814\u7a76\u7d50\u679c\uff1a<\/strong><\/p>\n<p>\u672c\u7bc7\u6587\u7ae0\u4e3b\u8981\u63a2\u8a0eRNA-binding protein Musashi-1 \u5728\u5927\u8178\u764c\u4e2d\u626e\u6f14\u6297\u85e5\u6027\u7684\u89d2\u8272\uff0cMusashi-1\u6703\u4fc3\u9032 CD44+ \u5927\u8178\u764c\u5e79\u7d30\u80de\u589e\u751f\u4ee5\u53caanti-apoptotic stress granules (SGs)\u5206\u6ccc. \u5c24\u5176\u5728\u5316\u7642\u85e5\u72695- uorouracil \u4f5c\u7528\u7684\u5927\u8178\u764c\u7d30\u80de\u6703\u8a98\u767cMusashi-1 formed SGs\uff0c\u7d30\u80de\u5167\u7684 Musashi-1 SGs\u4e5f\u6703\u589e\u52a0\u5927\u8178\u764c\u7d30\u80de\u7684\u6297\u85e5\u6027. \u81e8\u5e8a\u5927\u8178\u764c\u6aa2\u9ad4\u5206\u6790\u767c\u73fe\u5728stage IIA and IIB\u7684\u5927\u8178\u764c\u6aa2\u9ad4\u4e2d\uff0cMusashi-1 protein \u7684\u8868\u73fe\u5c24\u5176\u660e\u986f\u3002<\/p>\n<p><strong>\u00a02.<\/strong><strong>\u7814\u7a76\u8ca2\u737b\u8207\u81e8\u5e8a\u61c9\u7528\uff1a<\/strong><\/p>\n<p>\u672c\u7bc7\u8ad6\u6587\u7814\u7a76\u5728\u65bc\u5927\u8178\u764c\u6cbb\u7642\u4e2d\u7522\u751f\u4e4b\u6297\u85e5\u6027\u6a5f\u8f49\u6709\u91cd\u8981\u4e4b\u767c\u73fe\uff0c\u65bc\u672a\u4f86\u91dd\u5c0d\u767c\u73fe\u4e4b\u6a5f\u8f49\u53ef\u6709\u6cbb\u7642\u65b9\u5411\u4e4b\u5ef6\u4f38\u61c9\u7528\u3002<!--more--><\/p>\n<p><strong><a href=\"https:\/\/web.csh.org.tw\/web\/csh\/wp-content\/uploads\/2017\/03\/2017-11.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-24448 aligncenter\" src=\"https:\/\/web.csh.org.tw\/web\/csh\/wp-content\/uploads\/2017\/03\/2017-11.jpg\" alt=\"\" width=\"720\" height=\"960\" \/><\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00a01.\u7814\u7a76\u7d50\u679c\uff1a \u672c\u7bc7\u6587\u7ae0\u4e3b\u8981\u63a2\u8a0eRNA-binding protein Musashi-1 \u5728\u5927\u8178\u764c\u4e2d\u626e\u6f14\u6297 [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-3192","post","type-post","status-publish","format-standard","hentry","category-4"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/3192"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3192"}],"version-history":[{"count":4,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/3192\/revisions"}],"predecessor-version":[{"id":24449,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/3192\/revisions\/24449"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3192"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3192"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3192"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}