{"id":26978,"date":"2024-11-25T17:17:33","date_gmt":"2024-11-25T09:17:33","guid":{"rendered":"https:\/\/web.csh.org.tw\/web\/csh\/?p=26978"},"modified":"2024-11-25T17:17:34","modified_gmt":"2024-11-25T09:17:34","slug":"%e8%82%ba%e8%85%ba%e7%99%8c%e7%9a%84%e5%85%a8%e5%a4%96%e9%a1%af%e5%ad%90%e5%ae%9a%e5%ba%8f%e5%92%8cmicrorna%e5%88%86%e6%9e%90%e7%a2%ba%e5%ae%9a%e7%ac%aci%e6%9c%9f%e5%8f%8a%e5%85%b6%e5%88%86%e6%9c%9f","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/csh\/?p=26978","title":{"rendered":"\u80ba\u817a\u764c\u7684\u5168\u5916\u986f\u5b50\u5b9a\u5e8f\u548cMicroRNA\u5206\u6790\u78ba\u5b9a\u7b2cI\u671f\u53ca\u5176\u5206\u671f\u816b\u7624\u98a8\u96aa\u9810\u6e2c\u7279\u5fb5"},"content":{"rendered":"
    \n
  1. \u7814\u7a76\u7d50\u679c\uff1a<\/strong><\/li>\n<\/ol>\n

    \u5728EGFR\u3001KRAS\u3001TP53\u3001CTNNB1\u548c\u5176\u4ed6\u516d\u500b\u57fa\u56e0\u4e2d\uff0c\u6709\u5341\u516d\u500b\u975e\u540c\u7fa9\u7a81\u8b8a\uff0c\u4ee5\u57fa\u56e0\u8b8a\u7570\u983b\u7387\uff08VAF\uff09\u7684\u65b9\u5f0f\u5448\u73fe\u51fa\u5291\u91cf\u4f9d\u8cf4\u6027\uff0c\u8207\u60e1\u6027\u8907\u767c\u751f\u5b58\uff08RFS\uff09\u5448\u73fe\u8ca0\u76f8\u95dc\u3002\u6211\u5011\u5efa\u7acbmaxVAF\u6307\u6a19\u7528\u65bc\u91cf\u5316\u9664EGFR\u4ee5\u5916\u7684\u57fa\u56e0\u4e2d\u7684\u7e3d\u9ad4\u7a81\u8b8a\u8ca0\u8377\u3002\u9ad8maxVAF\u5206\u6578\u80fd\u5920\u5340\u5206\u51fa\u4e00\u5c0f\u90e8\u5206\u9ad8\u98a8\u96aa\u7684\u7b2cI\u671f\u80ba\u817a\u764c\u60a3\u8005\uff08\u4e2d\u4f4dRFS\uff1a4.5 vs. 69.5\u500b\u6708\uff1b\u98a8\u96aa\u6bd4 = 10.5\uff0c95%\u4fe1\u8cf4\u5340\u9593 = 4.22\u201326.12\uff0cP < 0.001\uff09\u3002\u5728\u4e9e\u5206\u671f\u6c34\u5e73\u4e0a\uff0c\u767c\u73fe\u9ad8maxVAF\u6216\u9ad8miR-31\u7684\u60a3\u8005\u98a8\u96aa\u8f03\u9ad8\uff1bIA\u671f\uff08\u4e2d\u4f4dRFS\uff1a32.1 vs. 122.8\u500b\u6708\uff0cP = 0.005\uff09\u548cIB\u671f\uff08\u4e2d\u4f4dRFS\uff1a7.1 vs. 26.2\uff0cP = 0.049\uff09\u3002microRNAs\u3001miR-182\u3001miR-183\u548cmiR-196a\uff0c\u8207EGFR\u7a81\u8b8a\u548cIB\u671f\u60a3\u8005\u60e1\u6027\u8907\u767c\u751f\u5b58\u5448\u73fe\u76f8\u95dc\u3002<\/p>\n

      \n
    1. \u7814\u7a76\u8ca2\u737b\u8207\u81e8\u5e8a\u61c9\u7528\uff1a<\/strong><\/li>\n<\/ol>\n

      \u9019\u9805\u7814\u7a76\u9996\u5148\u5efa\u69cb\u4e86\u53f0\u7063\u4e00\u671fLUAD\u7684\u57fa\u56e0\u9ad4\u8b8a\u7570\u5168\u666f\uff0c\u7279\u5225\u805a\u7126\u65bcEGFR\u7a81\u8b8a\u3002\u96d6\u7136EGFR\u7a81\u8b8a\u6700\u5e38\u898b\uff0c\u4f46\u5728\u672c\u7814\u7a76\u4e2d\u5c0d\u5fa9\u767c\u7121\u5f71\u97ff\u3002\u901a\u904e\u95dc\u6ce8\u6bd4\u9810\u671f\u66f4\u983b\u7e41\u767c\u751f\u7684\u975eEGFR\u57fa\u56e0\u7684\u975e\u540c\u7fa9NSPM\uff0c\u5f15\u5165\u4e86\u4e00\u500b\u7a31\u70bamaxVAF\u7684\u65b0\u6307\u6a19\uff0c\u5c0d\u5340\u5206\u4e00\u671fLUAD\u4e2d\u7684\u9ad8\u98a8\u96aa\u60a3\u8005\u5177\u6709\u4fe1\u606f\u50f9\u503c\u3002<\/p>\n

      \u7136\u800c\uff0c\u9019\u9805\u7814\u7a76\u9762\u81e8\u9ad4\u7a81\u8b8a\u8b58\u5225\u7684\u6311\u6230\uff0c\u5305\u62ec\u4f86\u81ea\u816b\u7624\u6a23\u672c\u7684\u932f\u8aa4\u548c\u6b63\u5e38\u6a23\u672c\u6df1\u5ea6\u4e0d\u8db3\u3002\u901a\u904e\u4f7f\u7528\u591a\u500b\u63a7\u5236\u6a23\u672c\u7684\u5be6\u8b49\u6ffe\u6ce2\u5668\uff0c\u7814\u7a76\u6210\u529f\u6e1b\u5c11\u6f5b\u5728\u7684\u507d\u967d\u6027\u3002\u6700\u7d42\uff0c\u6574\u540815\u500b\u975eEGFR\u975e\u540c\u7fa9NSPM\u5f62\u6210maxVAF\u5206\u6578\uff0c\u8a72\u5206\u6578\u8207RFS\u5728\u6211\u5011\u7684\u7fa4\u9ad4\u548c\u767d\u4eba\u7fa4\u9ad4\u4e2d\u5747\u5448\u73fe\u986f\u8457\u76f8\u95dc\u3002\u9019\u9805\u7814\u7a76\u7684\u5275\u65b0\u4e4b\u8655\u5728\u65bc\u63d0\u4f9b\u4e86\u5c0d\u53f0\u7063\u4e00\u671fLUAD\u60a3\u8005\u9ad8\u98a8\u96aa\u7684\u6df1\u5165\u7406\u89e3\uff0c\u70ba\u500b\u9ad4\u5316\u6cbb\u7642\u548c\u5f8c\u7e8c\u8ffd\u8e64\u63d0\u4f9b\u4e86\u6709\u529b\u652f\u6301\u3002<\/p>\n

      \"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

      \u7814\u7a76\u7d50\u679c\uff1a \u5728EGFR\u3001KRAS\u3001TP53\u3001CTNNB1\u548c\u5176\u4ed6\u516d\u500b\u57fa\u56e0\u4e2d\uff0c\u6709\u5341\u516d\u500b\u975e\u540c\u7fa9\u7a81\u8b8a\uff0c\u4ee5\u57fa\u56e0\u8b8a\u7570\u983b\u7387\uff08 […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-26978","post","type-post","status-publish","format-standard","hentry","category-4"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/26978"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26978"}],"version-history":[{"count":1,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/26978\/revisions"}],"predecessor-version":[{"id":26980,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/26978\/revisions\/26980"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26978"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26978"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}