{"id":26931,"date":"2024-11-25T14:36:25","date_gmt":"2024-11-25T06:36:25","guid":{"rendered":"https:\/\/web.csh.org.tw\/web\/csh\/?p=26931"},"modified":"2024-11-25T14:36:27","modified_gmt":"2024-11-25T06:36:27","slug":"glutamine-metabolism-controls-amphiregulin-facilitated-chemoresistance-to-cisplatin-in-human-chondrosarcoma","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/csh\/?p=26931","title":{"rendered":"Glutamine metabolism controls amphiregulin-facilitated chemoresistance to cisplatin in human chondrosarcoma"},"content":{"rendered":"<ol>\n<li><strong>\u7814\u7a76\u7d50\u679c\uff1a<\/strong><\/li>\n<\/ol>\n<p>\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u5728\u6297\u85e5\u6027\u7d30\u80de\u4e2d\u9ad8\u5ea6\u6d3b\u5316\uff0c\u4f46\u8461\u8404\u7cd6\u4ee3\u8b1d\u4e26\u6c92\u6709\u3002\u96d9\u8abf\u86cb\u767d\uff08AR\uff09\u589e\u5f37\u9ea9\u91af\u80fa\u9178\u4ee3\u8b1d\u4e26\u4fc3\u9032 NADPH \u7522\u751f\u4e26\u6291\u5236\u6d3b\u6027\u6c27 (ROS)\u7d2f\u7a4d\u5f9e\u800c\u652f\u6301\u4eba\u985e\u8edf\u9aa8\u8089\u7624\u5c0d\u9806\u9251\u7684\u6297\u85e5\u6027\u3002<\/p>\n<p>\u5728\u9ad4\u5167\u9806\u9251\u6297\u85e5\u6027\u7684\u8edf\u9aa8\u8089\u7624\u7d30\u7684AR\u8868\u9054\u7684\u6572\u4f4e\u53ef\u964d\u4f4e SLC1A5\u548cGLS\u7684\u8868\u9054\u3002<\/p>\n<ol start=\"2\">\n<li><strong>\u7814\u7a76\u8ca2\u737b\u8207\u81e8\u5e8a\u61c9\u7528\uff1a<\/strong><\/li>\n<\/ol>\n<p>Amphiregulin(AR) \u548cGlutamine(\u8c37\u6c28\u9170\u80fa) \u4ee3\u8b1d\u503c\u5f97\u4f5c\u70ba\u6cbb\u7642\u9806\u9251\u6297\u85e5\u6027\u7684\u4eba\u985e\u8edf\u9aa8\u8089\u7624\u7684\u6a19\u9776\u6cbb\u7642\u3002<!--more--><a href=\"https:\/\/web.csh.org.tw\/web\/csh\/wp-content\/uploads\/2024\/11\/2023-4-7.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-26932\" src=\"https:\/\/web.csh.org.tw\/web\/csh\/wp-content\/uploads\/2024\/11\/2023-4-7-724x1024.jpg\" alt=\"\" width=\"640\" height=\"905\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7814\u7a76\u7d50\u679c\uff1a \u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u5728\u6297\u85e5\u6027\u7d30\u80de\u4e2d\u9ad8\u5ea6\u6d3b\u5316\uff0c\u4f46\u8461\u8404\u7cd6\u4ee3\u8b1d\u4e26\u6c92\u6709\u3002\u96d9\u8abf\u86cb\u767d\uff08AR\uff09\u589e\u5f37\u9ea9\u91af\u80fa\u9178\u4ee3\u8b1d\u4e26\u4fc3\u9032 N [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-26931","post","type-post","status-publish","format-standard","hentry","category-4"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/26931"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26931"}],"version-history":[{"count":1,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/26931\/revisions"}],"predecessor-version":[{"id":26933,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/26931\/revisions\/26933"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26931"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26931"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26931"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}