{"id":25985,"date":"2024-11-05T15:52:35","date_gmt":"2024-11-05T07:52:35","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/csh\/?p=25985"},"modified":"2024-11-13T11:21:35","modified_gmt":"2024-11-13T03:21:35","slug":"microrna-let-7a-7e-and-133a-attenuate-hypoxia-induced-atrial-fibrosis-via-targeting-collagen-expression-and-the-jnk-pathway-in-hl1-cardiomyocytes","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/csh\/?p=25985","title":{"rendered":"MicroRNA Let-7a, -7e and -133a Attenuate Hypoxia-Induced Atrial Fibrosis via Targeting Collagen Expression and the JNK Pathway in HL1 Cardiomyocytes"},"content":{"rendered":"<p><strong>1.<\/strong><strong>\u7814\u7a76\u7d50\u679c\uff1a<\/strong><\/p>\n<p>\u767c\u73feCOL1A \u548c COL3A\u662f\u9ad4\u5916\u7f3a\u6c27\u5fc3\u623f\u5fc3\u808c\u7d30\u80de\u4e2d miR-let-7a\u3001miR-7e \u548c miR-133a \u7684\u76f4\u63a5\u8abf\u7bc0\u9776\u9ede\u3002 COL1A \u548c COL3A \u7684\u8868\u9054\u53d7\u5230 miRNA \u6a21\u64ec\u7269\u548c antagomir \u8655\u7406\u7684\u5f71\u97ff\uff0c\u800c\u7f3a\u6c27\u8a98\u5c0e\u7684\u81a0\u539f\u86cb\u767d\u8868\u9054\u53d7\u5230 miR-133a\u3001miR-let-7a \u6216 miR-let-7e \u7684\u6291\u5236\u3002 JNK\u901a\u8def\u5728\u5fc3\u623f\u7e96\u7dad\u5316\u7684\u767c\u75c5\u6a5f\u5236\u4e2d\u81f3\u95dc\u91cd\u8981\u3002 JNK \u6291\u88fd\u5291 SP600125 \u589e\u52a0\u4e86 miRNA\u8868\u9054\u4e26\u6291\u5236\u7e96\u7dad\u5316\u6a19\u8a8c\u7269 COL1A \u548c COL3A\u3002<\/p>\n<p><strong>2.\u7814\u7a76\u8ca2\u737b\u8207\u81e8\u5e8a\u61c9\u7528\uff1a<\/strong><\/p>\n<p>miRNA let-7a\u3001miR-let-7e \u548c miR-133a \u7d93\u904eJNK \u901a\u8def\u7684\u8868\u9054\u548c\u8f49\u9304\u5f8c\u6291\u5236\u8207\u901a\u904e\u6291\u88fd\u81a0\u539f\u86cb\u767d\u5728\u5fc3\u623f\u7e96\u7dad\u5316\u7f3a\u6c27\u76f8\u95dc\u4e2d\u767c\u63ee\u91cd\u8981\u4f5c\u7528\u3002 \u9019\u4e9b\u65b0\u767c\u73fe\u53ef\u80fd\u5f15\u5c0e\u4ee5\u958b\u767c\u65b0\u7684\u6cbb\u7642\u7b56\u7565\u6216\u85e5\u7269\u3002<\/p>\n<p><!--more--><\/p>\n<p><strong><a href=\"https:\/\/web.csh.org.tw\/web\/csh\/wp-content\/uploads\/2024\/11\/2022-4-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-25988\" src=\"https:\/\/web.csh.org.tw\/web\/csh\/wp-content\/uploads\/2024\/11\/2022-4-1.jpg\" alt=\"\" width=\"720\" height=\"960\" \/><\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1.\u7814\u7a76\u7d50\u679c\uff1a \u767c\u73feCOL1A \u548c COL3A\u662f\u9ad4\u5916\u7f3a\u6c27\u5fc3\u623f\u5fc3\u808c\u7d30\u80de\u4e2d miR-let-7a\u3001miR-7e \u548c [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-25985","post","type-post","status-publish","format-standard","hentry","category-4"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/25985"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25985"}],"version-history":[{"count":1,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/25985\/revisions"}],"predecessor-version":[{"id":25989,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=\/wp\/v2\/posts\/25985\/revisions\/25989"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25985"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25985"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/csh\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25985"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}