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class=\"wp-block-heading\"><strong>\u975e\u51dd\u8840\u56e0\u5b50\u6cbb\u7642<\/strong><\/h4>\n\n\n\n<p>\n\n\u76f8\u8f03\u65bcA\u578b\u8840\u53cb\u75c5\u5df2\u7d93\u7814\u767c\u7b2c\u516b\u56e0\u5b50\u96d9\u7279\u7570\u6027\u55ae\u682a\u6297\u9ad4\u9019\u985e\u6a21\u4eff\u7b2c\u516b\u56e0\u5b50\u85e5\u7269\uff0c\u76ee\u524d\u7b2c\u4e5d\u56e0\u5b50\u4e26\u6c92\u6709\u76f8\u985e\u4f3c\u7684\u85e5\u7269\u6b63\u5728\u9032\u884c\u81e8\u5e8a\u7814\u7a76\u4e2d\uff0c\u56e0\u6b64B\u578b\u8840\u53cb\u75c5\u7684\u975e\u56e0\u5b50\u6cbb\u7642\uff0c\u4e3b\u8981\u4ee5\u300c\u51dd\u8840\u529f\u80fd\u518d\u5e73\u8861\u300d\u6a5f\u8f49\u7684\u85e5\u7269\u70ba\u4e3b\uff0c\u60f3\u8981\u77ad\u89e3\u6240\u8b02\u7684\u300c\u518d\u5e73\u8861\u300d\u6cbb\u7642\uff08Rebalance therapy\uff09\u524d\uff0c\u5fc5\u9808\u5148\u77ad\u89e3\u4eba\u9ad4\u5167\u7684\u51dd\u8840\u6a5f\u5236\u5c31\u5982\u540c\u8e7a\u7ff9\u677f\u7684\u5e73\u8861\u4e00\u822c\uff0c\u5de7\u5999\u7684\u5229\u7528\u51dd\u8840\u529f\u80fd\u8207\u6297\u51dd\u8840\u529f\u80fd\u4e4b\u9593\u7684\u5e73\u8861\u6027\u4f86\u907f\u514d\u51fa\u8840\u8207\u767c\u751f\u8840\u6813\u3002\n\n<\/p>\n\n\n\n<p>\n\n\u76f8\u8f03\u65bc\u904e\u53bb\u88dc\u5145\u51dd\u8840\u56e0\u5b50\u4f86\u300c\u589e\u52a0\u300d\u51dd\u8840\u529f\u80fd\uff0c\u6062\u5fa9\u56e0\u51dd\u8840\u56e0\u5b50\u7f3a\u5c11\u5c0e\u81f4\u7684\u7ff9\u7ff9\u677f\u4e0d\u5e73\u8861\u3002\u300c\u518d\u5e73\u8861\u300d\u6cbb\u7642\u5247\u5229\u7528\u4e86\u300c\u6e1b\u5c11\u300d\u6297\u51dd\u8840\u529f\u80fd\u7684\u65b9\u5f0f\uff0c\u4f86\u6062\u5fa9\u7ff9\u7ff9\u677f\u7684\u5e73\u8861\u3002\u9019\u6a23\u7684\u751f\u7406\u6a5f\u8f49\u5728\u4eba\u9ad4\u5167\u4e5f\u6703\u81ea\u7136\u767c\u751f\uff0c\u8209\u4f8b\u4f86\u8aaa\uff0c\u5728\u80ce\u5152\u6216\u65b0\u751f\u5152\u6642\u671f\uff0c\u7531\u65bc\u809d\u81df\u8207\u8840\u5c0f\u677f\u7684\u4e0d\u6210\u719f\uff0c\u5c0e\u81f4\u51dd\u8840\u529f\u80fd\u8207\u6297\u51dd\u8840\u529f\u80fd\u540c\u6642\u4e0b\u964d\uff0c\u56e0\u6b64\u7dad\u6301\u4e00\u500b\u76f8\u8f03\u65bc\u6b63\u5e38\u6210\u4eba\u800c\u8a00\uff0c\u8f03\u4f4e\u7684\u51dd\u8840\u529f\u80fd\u5e73\u8861\uff08\u4f8b\u5982\u65b0\u751f\u5152\u50c5\u670930%\u51dd\u8840\u529f\u80fd\uff0c\u7136\u800c\u6297\u51dd\u8840\u529f\u80fd\u4e5f\u53ea\u670930%\uff09\u3002\n\n<\/p>\n\n\n\n<p>\n\n\u800c\u518d\u5e73\u8861\u85e5\u7269\u7a2e\u985e\u7e41\u591a\uff0c\u4f9d\u7167\u5176\u5c0d\u61c9\u7684\u6297\u51dd\u8840\u86cb\u767d\u8207\u9032\u884c\u4e2d\u7684\u81e8\u5e8a\u7814\u7a76\uff0c\u53c8\u53ef\u4ee5\u5340\u5206\u70ba\u4e09\u5927\u6a5f\u8f49\uff1a\u7b2c\u4e00\u985e\u662f\u91dd\u5c0d\u300c\u7d44\u7e54\u56e0\u5b50\u8def\u5f91\u6291\u5236\u86cb\u767d\uff08Tissue Factor Pathway Inhibitor, TFPI\uff09\u300d\u529f\u80fd\u9032\u884c\u6291\u5236\u7684TFPI\u6297\u9ad4\uff08anti-TFPIantibodies\uff09\uff0c\u7b2c\u4e8c\u985e\u5247\u662f\u6291\u5236\u300c\u6297\u51dd\u8840\u9176\u86cb\u767d\uff08Anti-thrombin III, AT-III\uff09\u300d\u88fd\u9020\u7684\u5c0f\u7247\u6bb5\u5e72\u64feRNA\uff08small interfering RNA,siRNA\uff09\uff0c\u7b2c\u4e09\u7a2e\u5247\u662f\u6291\u5236\u6d3b\u5316\u86cb\u767d\u8ceaC\uff08activatedProtein C, APC\uff09\u7684\u6291\u5236\u9176\uff08SerpinPC\uff09\u3002\n\n<\/p>\n\n\n\n<p>\u96d6\u7136\u4e09\u985e\u85e5\u7269\u540c\u6a23\u90fd\u85c9\u7531\u6291\u5236\u6297\u51dd\u8840\u86cb\u767d\u4f86\u9054\u5230\u300c\u51dd\u8840\u529f\u80fd\u518d\u5e73\u8861\u300d\u7684\u9810\u9632\u51fa\u8840\u6548\u679c\uff0c\u4e09\u985e\u518d\u5e73\u8861\u85e5\u7269\u537b\u4f7f\u7528\u4e86\u4e09\u7a2e\u5b8c\u5168\u4e0d\u540c\u7684\u6280\u8853\uff08\u4eba\u985e\u55ae\u682a\u6297\u9ad4\u3001\u5c0f\u7247\u6bb5\u5e72\u64feRNA\u3001\u6291\u5236\u9176\uff09\u8207\u5f71\u97ff\u4e0d\u540c\u7684\u6297\u51dd\u8840\u86cb\u767d\uff08TFPI\u86cb\u767d\u3001\u6297\u51dd\u8840\u9176\u86cb\u767d\u3001\u6d3b\u5316C\u86cb\u767d\uff09\uff0c\u56e0\u6b64\u7121\u6cd5\u76f4\u63a5\u6bd4\u8f03\u3002\u800c\u300c\u518d\u5e73\u8861\u300d\u6cbb\u7642\u6709\u5176\u76ae\u4e0b\u6ce8\u5c04\u3001\u85e5\u6548\u9577\uff08\u6700\u9577\u53ef\u4ee5\u5169\u500b\u6708\u6ce8\u5c04\u4e00\u6b21\uff09\u3001\u6548\u679c\u4f73\uff08\u53ef\u4ee5\u9054\u523010-40%\u4ee5\u4e0a\u7684\u4fdd\u8b77\u6548\u679c\uff09\u7b49\u512a\u9ede\uff0c\u7136\u800c\u4e5f\u6709\u5176\u300c\u53ef\u80fd\u5f15\u8d77\u8840\u6813\u98a8\u96aa\u300d\u3001\u300c\u8207\u904e\u53bb\u51dd\u8840\u56e0\u5b50\u6cbb\u7642\u5b8c\u5168\u4e0d\u540c\uff0c\u56e0\u6b64\u7f3a\u4e4f\u7d93\u9a57\u300d\u7b49\u7f3a\u9ede\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e09\u7a2e\u518d\u5e73\u8861\u6cbb\u7642\u7c21\u4ecb\uff1a<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u6291\u5236TFPI\u86cb\u767d<\/strong><\/h4>\n\n\n\n<p>TFPI\u86cb\u767d\u5728\u4eba\u9ad4\u5167\u85c9\u7531\u6291\u5236\u7b2c\u4e03\u56e0\u5b50\u8207\u7b2c\u5341\u56e0\u5b50\u7684\u529f\u80fd\uff0c\u4f86\u9054\u5230\u6291\u5236\u51dd\u8840\u7684\u6548\u679c\uff0c\u56e0\u6b64\u5982\u679c\u80fd\u5920\u6291\u5236TFPI\u86cb\u767d\u7684\u6297\u51dd\u8840\u529f\u80fd\uff0c\u5c31\u53ef\u4ee5\u6062\u5fa9\u8840\u53cb\u75c5\u60a3\u8005\u7684\u51dd\u8840\u5e73\u8861\uff0c\u4f86\u9054\u5230\u9810\u9632\u51fa\u8840\u7684\u76ee\u7684\u3002\u56e0\u6b64\u5ee0\u5546\u7814\u767c\u51fa\u6291\u5236TFPI\u86cb\u767d\u7684\u4eba\u985e\u55ae\u682a\u6297\u9ad4\uff0c\u85c9\u7531\u6297\u9ad4\u6291\u5236\u8840\u6db2\u4e2d\u7684TFPI\u86cb\u767d\uff0c\u53ef\u4ee5\u6709\u6548\u9810\u9632\u8840\u53cb\u75c5\u60a3\u8005\u51fa\u8840\u3002\u76ee\u524d\u5206\u5225\u6709\u5169\u5bb6\u5ee0\u5546\u5df2\u7d93\u4e0a\u5e02\u6216\u9032\u5165\u7b2c\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u3002<\/p>\n\n\n\n<p>\n\n\u7531\u65bc\u4eba\u9ad4\u7684TFPI\u86cb\u767d\u50c5\u6709\u5c11\u90e8\u5206\u5b58\u5728\u8840\u6db2\u4e4b\u4e2d\uff0c\u5176\u5927\u591a\u6578\uff0890%\uff09\u5247\u5132\u5b58\u65bc\u8840\u7ba1\u5167\u76ae\u7d30\u80de\u8207\u8840\u5c0f\u677f\u5167\uff0c\u56e0\u6b64\u904e\u53bb\u5728\u6291\u5236TFPI\u86cb\u767d\u85e5\u7269\u7684\u7814\u767c\u4e2d\uff0c\u9047\u5230\u8a31\u591a\u56f0\u96e3\uff0c\u4f8b\u5982\u65bd\u6253\u5f8c\u53ef\u80fd\u53cd\u800c\u589e\u52a0\u51fa\u8840\u6216\u65bd\u6253\u5f8c\u767c\u751f\u4e0d\u660e\u539f\u56e0\u7684\u8840\u6813\u3002\n\n<\/p>\n\n\n\n<p>\u7136\u800c\u6700\u7d42\u4e0a\u5e02\u7522\u54c1\u7a81\u7834\u842c\u96e3\uff0c\u7b2c\u4e09\u671f\u7814\u7a76\u8b49\u5be6\u6bcf\u5929\u65bd\u6253\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\uff0c\u53ef\u4ee5\u9054\u5230\u6709\u6548\u7684\u4fdd\u8b77\u529b\uff0c\u76ee\u524d\u5728\u52a0\u62ff\u5927\u5df2\u7d93\u53d6\u5f97\u5c0d\u65bcB\u578b\u8840\u53cb\u75c5\u5408\u4f75\u6297\u9ad4\u60a3\u8005\u7684\u9810\u9632\u6cbb\u7642\u9069\u61c9\u75c7\uff0c\u5176\u5982\u540c\u6ce8\u5c04\u80f0\u5cf6\u7d20\u822c\u7684\u7b46\u91dd\u5291\u578b\u66f4\u662f\u5728\u6bcf\u65e5\u76ae\u4e0b\u6ce8\u5c04\u6642\u517c\u9867\u65b9\u4fbf\u8207\u5b89\u5168\u3002<\/p>\n\n\n\n<p>\u800c\u7b2c\u4e8c\u5bb6\u5ee0\u5546\u76ee\u524d\u7b2c\u4e09\u671f\u7814\u7a76\u4ecd\u7dad\u6301\u6bcf\u9031\u76ae\u4e0b\u6ce8\u5c04\u4e00\u6b21\u7684\u983b\u7387\uff0c\u5728\u7b2c\u4e8c\u671f\u7814\u7a76\u4e2d\u8b49\u5be6\u53ef\u4ee5\u6709\u6548\u907f\u514d\u51fa\u8840\uff0c\u7136\u800c\u90e8\u5206\u60a3\u8005\u51fa\u73fe\u4e0d\u660e\u539f\u56e0\u7684\u8840\u6813\u6307\u6578(D-dimer)\u5347\u9ad8\uff0c\u4ecd\u9700\u8981\u9032\u4e00\u6b65\u7684\u7814\u7a76\u3002\u53f0\u7063\u4e5f\u6709B\u578b\u8840\u53cb\u75c5\u5408\u4f75\u6297\u9ad4\u60a3\u8005\u6b63\u5728\u53c3\u8207\u9019\u9805\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n\n\n\n<h4 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class=\"wp-block-heading\">\u6291\u5236\u6d3b\u5316C\u86cb\u767d<\/h4>\n\n\n\n<p>C\u86cb\u767d\uff08Protein C\uff09\u5728\u4eba\u9ad4\u5167\u540c\u6a23\u70ba\u975e\u5e38\u91cd\u8981\u7684\u6297\u51dd\u8840\u86cb\u767d\uff0c\u5176\u6d3b\u5316\u5f8c\uff08Activated Protein C, 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