{"id":11716,"date":"2020-08-12T16:59:19","date_gmt":"2020-08-12T08:59:19","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/224100\/?p=11716"},"modified":"2020-08-12T16:59:20","modified_gmt":"2020-08-12T08:59:20","slug":"11716","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/224100\/?p=11716","title":{"rendered":""},"content":{"rendered":"\n

\u764c\u75c7\u514d\u75ab\u6cbb\u7642 – \u5167\u884c\u4eba\u770b\u9580\u9053 \uff08\u7b2c\u4e00\u7ae0\uff1a\u4eba\u9ad4\u7684\u764c\u75c7\u514d\u75ab\u9632\u885b\u6a5f\u8f49\uff09<\/h1>\n\n\n\n

\u66f4\u65b0\u65e5\u671f\uff1a2019\u5e745\u670824\u65e5
<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

\u7b2c\u4e00\u7ae0\uff1a\u4eba\u9ad4\u7684\u764c\u75c7\u514d\u75ab\u9632\u885b\u6a5f\u8f49<\/strong><\/h2>\n\n\n\n

1.<\/strong> \u7522\u751f\u764c\u7d30\u80de\u7684\u4e3b\u8981\u539f\u56e0\uff1a<\/strong> <\/p>\n\n\n\n

\u4eba\u9ad4\u7684\u7d44\u7e54\u5668\u5b98\u53d7\u5230\u50b7\u5bb3\u6642\u6703\u9032\u884c\u4fee\u5fa9\uff0c\u6700\u5178\u578b\u7684\u4f8b\u5b50\u5c31\u662fB\u578b\u809d\u708e\uff0c\u7576\u809d\u708e\u75c5\u6bd2\u4fb5\u5165\u809d\u7d30\u80de\u5f15\u8d77\u809d\u7d30\u80de\u58de\u6b7b\u6642\uff0c\u809d\u7d30\u80de\u6703\u9032\u884c\u518d\u751f\u8207\u5206\u88c2\uff0c\u7136\u800c\u5728\u6bcf\u4e00\u6b21\u7d30\u80de\u7684DNA\u8907\u88fd\u8207\u5206\u88c2\u3001\u65b0\u751f\u7684\u904e\u7a0b\u90fd\u6709\u53ef\u80fd\u7522\u751f\u57fa\u56e0\u7a81\u8b8a\uff0c\u7576\u57fa\u56e0\u7a81\u8b8a\u9020\u6210\u7d30\u80de\u5206\u88c2\u65b0\u751f\u7121\u6cd5\u63a7\u5236\uff0c\u5c31\u8b8a\u6210\u6240\u8b02\u7684\u816b\u7624\u7d30\u80de\uff1b\u7576\u816b\u7624\u4fb5\u72af\u5c40\u90e8\u6b63\u5e38\u7684\u5668\u5b98\u6216\u5177\u6709\u9060\u7aef\u8f49\u79fb\u7684\u7279\u8cea\u6642\uff0c\u5c31\u662f\u4ee4\u4eba\u8272\u8b8a\u7684\u300c\u764c\u75c7\u300d\u4e86\u3002
<\/p>\n\n\n\n

2. \u6e05\u9664\u816b\u7624\u7d30\u80de\u7684\u514d\u75ab\u5de1\u5f0b\u7cfb\u7d71\uff1a<\/strong> <\/p>\n\n\n\n

\u7531\u65bc\u4eba\u9ad4\u7d93\u5e38\u66b4\u9732\u65bc\u5916\u754c\u74b0\u5883\u4e2d\u7684\u5404\u7a2e\u50b7\u5bb3\uff0c\u4f8b\u5982\uff1a\u7a7a\u6c23\u4e2d\u6216\u98df\u7269\u4e2d\u7684\u5404\u7a2e\u6709\u5bb3\u7269\u8cea\uff0c\u7d44\u7e54\u8207\u5668\u5b98\u7684\u7d30\u80de\u5728\u53d7\u50b7\u5f8c\u6703\u9032\u884c\u4fee\u5fa9\uff0c\u4fee\u5fa9\u7684\u7684\u904e\u7a0b\u4e2d\u6703\u9032\u884c\u7d30\u80de\u5206\u88c2\u7522\u751f\u65b0\u7684\u7d30\u80de\u4e2d\uff0c\u7136\u800c\u5728\u6b64\u904e\u7a0b\u4e2d\u5076\u723e\u6703\u610f\u5916\u7684\u7522\u751f\u57fa\u56e0\u7a81\u8b8a\u7684\u7570\u5e38\u7d30\u80de\u3002\u8840\u6db2\u8207\u6dcb\u5df4\u7cfb\u7d71\u662f\u4eba\u9ad4\u4e3b\u8981\u7684\u514d\u75ab\u7cfb\u7d71\uff0c\u5169\u7a2e\u7cfb\u7d71\u5177\u6709\u5404\u7a2e\u7684\u514d\u75ab\u7d30\u80de\u5faa\u74b0\u5168\u8eab\uff0c\u8ca0\u8cac\u57f7\u884c\u75c5\u539f\u9ad4\u611f\u67d3\u6216\u6bd2\u7269\u5165\u4fb5\u6642\u7684\u514d\u75ab\u53cd\u61c9\u3002\u7576\u4e0a\u8ff0\u7684\u7570\u5e38\u7d30\u80de\u7522\u751f\u7684\u6642\u5019\uff0c\u5728\u8840\u6d41\u4e2d\u5de1\u5f0b\u7684\u81ea\u7136\u6bba\u624b\u7d30\u80de (nature killer cells) \u8207\u541e\u566c\u7d30\u80de\u6703\u627e\u5230\u4e26\u8655\u6b7b\u9019\u4e9b\u7570\u5e38\u7d30\u80de\u3002\u9019\u662f\u4eba\u9ad4\u91dd\u5c0d\u764c\u8b8a\u7d30\u80de\u7684\u521d\u7d1a\u514d\u75ab\u53cd\u61c9\uff0c\u7a31\u70ba\u5148\u5929\u6027\u514d\u75ab\uff08innate immunity \uff09\uff0c\u5148\u5929\u6027\u514d\u75ab\u4e0d\u5177\u6709\u67d0\u4e00\u7a2e\u764c\u7d30\u80de\u7684\u7279\u7570\u6027\uff0c\u9019\u6a23\u7684\u514d\u75ab\u53cd\u61c9\u5c0d\u9ad4\u5167\u7684\u5404\u7a2e\u7570\u5e38\u7d30\u80de\uff08\u764c\u7d30\u80de\uff09\u64c1\u6709\u4e00\u5b9a\u7a0b\u5ea6\u7684\u6bba\u50b7\u529b\uff0c\u5728\u591a\u6578\u7684\u72c0\u6cc1\u4e0b\uff0c\u5b83\u5011\u53ef\u4ee5\u9806\u5229\u5b8c\u6210\u6e05\u9664\u7570\u5e38\u7d30\u80de\u7684\u4efb\u52d9\uff0c\u4f46\u662f\u7576\u5b83\u5011\u5931\u6557\u7684\u6642\u5019\u4fbf\u610f\u8b02\u8457\u816b\u7624\u751a\u81f3\u764c\u75c7\u7684\u7522\u751f\u3002
<\/p>\n\n\n\n

3.\u764c\u6297\u539f\u8207\u9069\u61c9\u6027\u514d\u75ab\u7d30\u80de\u7684\u56e0\u679c\u95dc\u4fc2\uff1a<\/strong> <\/p>\n\n\n\n

\u7576\u764c\u7d30\u80de\u88ab\u4e0a\u8ff0\u514d\u75ab\u7d30\u80de\u6bba\u6b7b\u5f8c\uff0c\u90e8\u5206\u88ab\u5206\u89e3\u7684\u7d30\u80de\u788e\u7247\uff08\u901a\u5e38\u662f\u86cb\u767d\u6216\u8102\u86cb\u767d\uff09\u5c31\u6703\u6210\u70ba\u4ee3\u8868\u8a72\u764c\u7684\u764c\u6297\u539f\uff0c\u63a5\u8457\u4eba\u9ad4\u5c31\u6703\u555f\u52d5\u54fa\u4e73\u985e\u52d5\u7269\u7279\u6709\u7684\u9069\u61c9\u6027\u514d\u75ab\uff08adaptive immunity\uff09\uff0c\u7531\u6297\u539f\u5448\u905e\u7d30\u80de\uff1a \u6a39\u7a81\u72c0\u7d30\u80de(dendritic cells\uff1a DC) \u8ca0\u8cac\u541e\u566c\u4e26\u8655\u7406\u9019\u4e9b\u764c\u6297\u539f\uff0c\u518d\u5c07\u5b83\uff08\u5011\uff09\u50b3\u905e\u7d66\u9644\u8fd1\u7684T\u7d30\u80de\u3002\u651c\u5e36\u764c\u6297\u539f\u7684T\u7d30\u80de\u56de\u6d41\u5230\u9644\u8fd1\u7684\u6dcb\u5df4\u7cfb\u7d71\uff0c\u518d\u7531\u8f14\u52a9T\u7d30\u80de\uff08helper T cells\uff09\u5206\u6ccc\u7d30\u80de\u6fc0\u7d20\uff0c\u6d3b\u5316\u3001\u523a\u6fc0\u4e26\u5927\u91cf\u589e\u751f\u5177\u6709\u8a72\u764c\u6297\u539f\u7279\u7570<\/strong>\u6027\u7684\u7d30\u80de\u6bd2\u6027T\u7d30\u80de \uff08cytotoxic T cells\uff09\uff0c\u63a5\u8457\u9019\u4e9b\u7d30\u80de\u6bd2\u6027T\u7d30\u80de\u4fbf\u5de1\u5f0b\u5168\u8eab\u5c0b\u627e\u5177\u6709\u9019\u4e9b\u6297\u539f\u7684\u764c\u7d30\u80de\uff0c\u5c07\u4ed6\u5011\u9010\u4e00\u6d88\u6ec5\u3002\u9069\u61c9\u6027\u514d\u75ab\u5177\u6709\u6297\u539f\u7279\u7570\u6027\uff08\u63db\u8a00\u4e4b\uff0c\u6bcf\u4e00\u7a2e \u7279\u5b9a\u682a\u7d30\u80de\u6bd2\u6027T\u7d30\u80de\u53ea\u5c0d\u5177\u6709\u8a72\u7a2e\u764c\u6297\u539f\u7684\u764c\u7d30\u80de\u6709\u6bba\u50b7\u529b\uff09\u662f\u4eba\u9ad4\u5c0d\u6297\u816b\u7624\u6216\u764c\u75c7\u751f\u6210\u7684\u91cd\u8981\u6b66\u5668\u3002
<\/p>\n\n\n\n

4.\u764c\u75c7\u6cbb\u7642\u7684\u5169\u6b21\u91cd\u5927\u9769\u547d\uff1a\u6a19\u9776\u6cbb\u7642\u8207\u514d\u75ab\u6cbb\u7642<\/strong> <\/p>\n\n\n\n

\u518d\u5b8c\u7f8e\u7684\u9632\u79a6\u7cfb\u7d71\u90fd\u6709\u5931\u6557\u7684\u6642\u5019\uff0c\u6709\u4e00\u4e9b\u8070\u660e\u7684\u764c\u7d30\u80de\u6210\u529f\u5730\u8eb2\u904e\u4e0a\u8ff0\u7684\u5169\u9053\u514d\u75ab\u9632\u79a6\u7cfb\u7d71\uff0c\u5f62\u6210\u81f4\u547d\u7684\u764c\u75c7\u3002\u764c\u75c7\u7684\u6cbb\u7642\u904e\u53bb\u90fd\u4ee5\u5177\u6709\u7d30\u80de\u6bd2\u6027\u7684\u5316\u5b78\u85e5\u7269\u6216\u653e\u5c04\u6cbb\u7642\u70ba\u4e4b\uff0c\u9019\u7a2e\u6cbb\u7642\u65b9\u5f0f\u6703\u540c\u6642\u50b7\u5bb3\u6b63\u5e38\u7684\u7d30\u80de\uff0c\u526f\u4f5c\u7528\u5f88\u5927\u800c\u4e14\u6548\u679c\u6709\u9650\uff0c\u76f4\u523010\u591a\u5e74\u524d\u6a19\u9776\u85e5\u7269\u7684\u767c\u660e\u624d\u771f\u6b63\u5730\u555f\u52d5\u4e86\u6240\u8b02\u7684\u300c\u7cbe\u6e96\u91ab\u7642\u300d\uff08\u95dc\u65bc\u7cbe\u6e96\u91ab\u7642\u5c07\u53e6\u6709\u5c08\u6587\u8aaa\u660e\uff09\u3002\u57fa\u672c\u4e0a\uff0c\u6a19\u9776\u85e5\u7269\u85e5\u7269\u80fd\u5920\u6709\u6548\u5730\u6291\u5236\u764c\u7d30\u80de\u7684\u300c\u9a45\u52d5\u7a81\u8b8a\u300d\uff08driver mutation \uff09\u57fa\u56e0\uff0c\u963b\u6b62\u764c\u7d30\u80de\u7684\u5206\u88c2\uff1b\u81e8\u5e8a\u4e0a\u900f\u904e\u5c0d\u764c\u7d30\u80de\u7684\u57fa\u56e0\u6aa2\u6e2c\uff0c\u627e\u51fa\u764c\u9a45\u52d5\u7a81\u8b8a\u7684\u57fa\u56e0\u9ede\uff0c\u518d\u7d66\u4e88\u6291\u5236\u8a72\u57fa\u56e0\u9ede\u7684\u6a19\u9776\u85e5\u7269\uff0c\u9019\u6a23\u7684\u6cbb\u7642\u65b9\u6cd5\u53ef\u4ee5\u6709\u6548\u7684\u6cbb\u7642\u591a\u7a2e\u764c\u75c7\uff0c\u4f8b\u5982\uff1a\u80ba\u764c\u3001\u4e73\u764c\u3001\u8840\u764c\u7b49\uff0c\u9019\u662f\u764c\u75c7\u6cbb\u7642\u7684\u7b2c\u4e00\u6b21\u91cd\u5927\u9769\u547d\uff0c\u7b2c\u4e8c\u6b21\u9769\u547d\u5c31\u662f\u6700\u8fd1\u5e7e\u5e74\u65b9\u8208\u672a\u827e\u7684\u514d\u75ab\u6cbb\u7642\uff08immunotherapy \uff09\u3002\u904e\u53bb\u5e7e\u5341\u5e74\u4f86\uff0c\u91ab\u754c\u4e00\u76f4\u76f8\u4fe1\u900f\u904e\u8a98\u767c\u3001\u6539\u8b8a\u6216\u5f37\u5316\u67d0\u4e9b\u7279\u7570\u7684\u514d\u75ab\u529f\u80fd\u53ef\u4ee5\u6cbb\u7642\u6216\u81f3\u5c11\u63a7\u5236\u764c\u75c7\uff0c\u53ef\u60dc\u5927\u591a\u6578\u7684\u81e8\u5e8a\u8a66\u9a57\u90fd\u662f\u5931\u6557\u6536\u5834\uff0c\u63a5\u8457\u6211\u5011\u53ea\u91dd\u5c0d\u5169\u7a2e\u76ee\u524d\u6bd4\u8f03\u78ba\u5b9a\u7642\u6548\u7684\u514d\u75ab\u6cbb\u7642\u9032\u884c\u4ecb\u7d39\uff081\uff09\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\uff08immune checkpoint inhibitors\uff09\u3001\uff082\uff09\u514d\u75ab\u7d30\u80de\u6cbb\u7642\u3002<\/p>\n\n\n\n

\uff08\u5f85\u7e8c\uff09
<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u764c\u75c7\u514d\u75ab\u6cbb\u7642 – \u5167\u884c\u4eba\u770b\u9580\u9053 \uff08\u7b2c\u4e00\u7ae0\uff1a\u4eba\u9ad4\u7684\u764c\u75c7\u514d\u75ab\u9632\u885b\u6a5f\u8f49\uff09 <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11716","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/224100\/index.php?rest_route=\/wp\/v2\/posts\/11716"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/224100\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/224100\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/224100\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/224100\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11716"}],"version-history":[{"count":2,"href":"https:\/\/web.csh.org.tw\/web\/224100\/index.php?rest_route=\/wp\/v2\/posts\/11716\/revisions"}],"predecessor-version":[{"id":11721,"href":"https:\/\/web.csh.org.tw\/web\/224100\/index.php?rest_route=\/wp\/v2\/posts\/11716\/revisions\/11721"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/224100\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11716"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/224100\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11716"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/224100\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}