{"id":154,"date":"2017-07-13T16:11:28","date_gmt":"2017-07-13T08:11:28","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/224020\/?page_id=154"},"modified":"2017-07-13T16:12:53","modified_gmt":"2017-07-13T08:12:53","slug":"12-2","status":"publish","type":"page","link":"https:\/\/web.csh.org.tw\/web\/224020\/?page_id=154","title":{"rendered":"B\u578b\u809d\u708e\u6cbb\u7642"},"content":{"rendered":"<p style=\"text-align: center;\"><strong>\u6162\u6027B\u578b\u809d\u708e\u6cbb\u7642\u7684\u65b0\u8da8\u52e2<\/strong>\n<\/p>\n<p style=\"text-align: left;\">\u00a0 \u00a0 \u00a0 \u00a0\u611f\u67d3B\u578b\u809d\u708e\u75c5\u6bd2\uff0c\u6709\u76f8\u7576\u6bd4\u4f8b\u7684\u4eba\u6703\u8b8a\u6210\u6162\u6027\u809d\u708e\u3002\u5b30\u5e7c\u5152\u6642\u611f\u67d3B\u578b\u809d\u708e\u75c5\u6bd2\u670990%\u6703\u6f14\u8b8a\u6210\u6162\u6027\u5e36\u539f\u8005\uff0c\u9752\u6625\u671f\u7d04\u67091\/3\uff0c\u6210\u5e74\u4eba\u5247\u53ea\u67095~10%\u6f14\u8b8a\u6210\u6162\u6027\u5e36\u539f\u8005\u3002\u6211\u570b\u7531B\u578b\u809d\u708e\u8868\u9762\u6297\u539f(HBsAg)\u76db\u884c\u738710~15%\u4f86\u8a08\u7b97\uff0c\u5247\u6709\u4e8c\u767e\u842c\u70ba\u5e36\u539f\u8005\u3002\u9019\u4e9b\u5e36\u539f\u8005\u6709\u4e00\u90e8\u4efd\u572820\u6b72\u81f340\u6b72\u4e4b\u9593\u767c\u751f\u6240\u8b02\u7684\u201c\u6025\u6027\u589e\u60e1\u201d(acute exacerbation)\u5f8c\uff0cHBeAg\u8f49\u8b8a\u6210Anti-HBe\uff0cHBV DNA\u6d88\u5931\uff0c\u5148\u524d\u7684\u6d3b\u52d5\u6027\u809d\u708e\u6f38\u8da8\u7de9\u548c\uff0c\u53c8\u6210\u70ba\u5065\u5eb7\u5e36\u539f\u8005\u3002\u5176\u4e2d\u90e8\u4efd\u75c5\u4eba\u7531\u65bc\u591a\u6b21\u7684\u6025\u6027\u589e\u60e1\uff0c\u809d\u81df\u7834\u58de\u53b2\u5bb3\u800c\u6f14\u8b8a\u6210\u809d\u786c\u5316\uff0c\u6709\u5c11\u90e8\u4efd\u75c5\u4eba\u7531\u65bcHBV\u7684\u5d4c\u5165\uff0c\u4e4b\u5f8c\u767c\u751f\u809d\u764c\u3002\u56e0\u800c\u9019\u4e9b\u6162\u6027\u6d3b\u52d5\u6027\u809d\u708e\u662f\u6cbb\u7642\u7684\u91cd\u8981\u5c0d\u8c61\u3002<\/p>\n<p>\u76ee\u524d\u6cbb\u7642\u6162\u6027B\u578b\u809d\u708e\u6700\u6709\u5e0c\u671b\u7684\u7576\u63a8Interferon(IFN\u5e72\u64fe\u7d20)\u53calamivudine\u3002IFN\u70ba\u6297\u75c5\u6bd2\u88fd\u5291\uff0c\u4f7f\u7528IFN 5Mu\u6bcf\u9031\u4e09\u6b21\uff0c\u6cbb\u76424\u81f36\u500b\u6708\uff0c\u53ef\u5f9730~40%\u53cd\u61c9\u7387\u3002\u5c0d\u65bcALT\u9ad8\u65bc\u6b63\u5e385\u500d\u8005\uff0c\u5247\u4f7f\u7528lamivudine\uff08\u70badeoxycymidine\u985e\u6bd4\u7269\uff0c\u6709reverse transcriptase\u6291\u5236\u529f\u80fd\u53ca\u6291\u5236HBV DNA polymerase\uff09\u529f\u80fd\u6bcf\u5929\u53e3\u670d100mg\uff0c\u6cbb\u76421\u5e74\uff0c\u53cd\u61c9\u7387\u53ef\u905465%\u3002\u5c0d\u65bc\u90a3\u4e9bALT\u5c0f\u65bc\u6b63\u5e382\u500d\u8005\uff0c\u8868\u793a\u5bbf\u4e3b\u514d\u75ab\u529f\u80fd\u5c1a\u672a\u63d0\u5347\uff0c\u4e0d\u4f5c\u6cbb\u7642\uff1b\u4f46\u53ef\u5148\u7528\u985e\u56fa\u9187\u505a\u201c\u8abf\u6559\u201d(priming)\u3002\u809d\u529f\u80fd\u6b63\u5e38\u8005\u5247\u4e0d\u4f5c\u6cbb\u7642\u3002Precore mutant\u4e5f\u53ef\u8003\u616elamivudine\u7684\u6cbb\u7642\uff0c\u4f46\u9700\u5c0f\u5fc3\u8ffd\u8e64\u8207\u8a55\u4f30\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\u4f7f\u7528lamivudine\u4e00\u5e74\u5f8c\uff0c\u6709\u76f8\u7576\u6bd4\u7387\u7684\u60a3\u8005\uff0c\u7522\u751fYMDD\u8b8a\u7570\u682a\uff0c\u81e8\u5e8a\u4e0a\u9700\u5c0f\u5fc3\uff0c\u61c9\u8a72\u6bcf\u4f4d\u75c5\u60a3\u500b\u5225\u8a55\u4f30\u4f86\u6c7a\u5b9a\u6cbb\u7642\u7684\u9577\u77ed\u3002<br \/>\n\u5c0d\u65bc\u4f7f\u7528\u5e72\u64fe\u7d20\u6216lamivudine\u6cbb\u7642\u7121\u6548\u7684\u75c5\u4eba\u662f\u5426\u8003\u616e\u4f7f\u7528\u03b1-thymosin\u6216\u662ffamciclovir\u6216\u8005\u5176\u4ed6\u85e5\u7269\u505a\u5408\u4f75\u6cbb\u7642\uff0c\u5c1a\u5f85\u5927\u898f\u6a21\u7684\u5be6\u9a57\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6162\u6027B\u578b\u809d\u708e\u6cbb\u7642\u7684\u65b0\u8da8\u52e2 \u00a0 \u00a0 \u00a0 \u00a0\u611f\u67d3B\u578b\u809d\u708e\u75c5\u6bd2\uff0c\u6709\u76f8\u7576\u6bd4\u4f8b\u7684\u4eba\u6703\u8b8a\u6210\u6162 &hellip; <a href=\"https:\/\/web.csh.org.tw\/web\/224020\/?page_id=154\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":46,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-154","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/224020\/index.php?rest_route=\/wp\/v2\/pages\/154"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/224020\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/224020\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/224020\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/224020\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=154"}],"version-history":[{"count":3,"href":"https:\/\/web.csh.org.tw\/web\/224020\/index.php?rest_route=\/wp\/v2\/pages\/154\/revisions"}],"predecessor-version":[{"id":157,"href":"https:\/\/web.csh.org.tw\/web\/224020\/index.php?rest_route=\/wp\/v2\/pages\/154\/revisions\/157"}],"up":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/224020\/index.php?rest_route=\/wp\/v2\/pages\/46"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/224020\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}