![\"\"](\"https:\/\/web.csh.org.tw\/web\/222010\/wp-content\/uploads\/2019\/06\/Y412.jpg\")
<\/a><\/p>\n\u885b\u751f\u798f\u5229\u90e8\u65bc2018\u5e749\u67086\u65e5\u516c\u544a\u300a\u7279\u5b9a\u91ab\u7642\u6280\u8853\u6aa2\u67e5\u6aa2\u9a57\u91ab\u7642\u5100\u5668\u65bd\u884c\u6216\u4f7f\u7528\u7ba1\u7406\u8fa6\u6cd5\uff08\u7c21\u7a31\u7279\u7ba1\u6cd5\uff09\u300b\u6b63\u5f0f\u4e0a\u8def\uff0c\u53f0\u7063\u662f\u50c5\u6b21\u65bc\u65e5\u672c\u958b\u653e\u7d30\u80de\u6cbb\u7642\u5c08\u6cd5\u7684\u570b\u5bb6\uff0c\u958b\u653e\u591a\u9805\u81ea\u9ad4\u5e79\u7d30\u80de\u6cbb\u7642\u6280\u8853\u4e26\u5217\u70ba\u5e38\u898f\u91ab\u7642\u3002<\/p>\n
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\u5168\u7403\u4eba\u53e3\u6301\u7e8c\u671d\u9ad8\u9f61\u5316\u9081\u9032\u4e4b\u969b\uff0c\u6bcf\u500b\u570b\u4eba\u90fd\u6709\u6a5f\u6703\u6d3b\u5230100\u6b72\u3002\u7136\u800c\u6d3b\u5f97\u4e45\u537b\u4e0d\u4ee3\u8868\u6d3b\u5f97\u5065\u5eb7\uff0c\u76ee\u524d\u570b\u4eba\u300c\u5065\u5eb7\u5e73\u5747\u9918\u547d\u300d71\u6b72\uff0c\u4f46\u4e0d\u5065\u5eb7\u7684\u5b58\u6d3b\u5e74\u6578\u90548.8\u5e74\uff1b\u4e5f\u5c31\u662f\u8aaa\uff0c\u66f4\u9577\u58fd\u7684\u4eba\u751f\u4e2d\uff0c\u53ef\u80fd\u6709\u5927\u534a\u6642\u9593\u5728\u8870\u8001\u3001\u75c5\u5f31\u5931\u80fd\u4e2d\u6e21\u904e\u3002\u73fe\u4ee3\u4eba\u91cd\u8996\u7684\u4e0d\u53ea\u6d3b\u7684\u9577\uff0c\u66f4\u8981\u6d3b\u7684\u5065\u5eb7\uff1b\u5982\u4f55\u4f7f\u4eba\u9081\u5165\u8001\u5e74\u6642\u4ecd\u4fdd\u6709\u5065\u5eb7\u7684\u8eab\u9ad4\uff0c\u767e\u6b73\u611f\u89ba\u50cf\u516d\u5341\u6b72\uff0c\u5403\u7684\u4e0b\u3001\u8d70\u7684\u52d5\u3001\u73a9\u7684\u8d77\u7684\u4eba\u751f\uff0c\u7d66\u611b\u7684\u4eba\u6c92\u7169\u60f1\uff0c\u88ab\u611b\u7684\u4eba\u6c92\u75db\u82e6\uff0c\u65e9\u5df2\u6210\u70ba\u5404\u570b\u91ab\u85e5\u7814\u767c\u7684\u91cd\u8981\u8ab2\u984c\u3002<\/p>\n
\u81ea\u9ad4\u5e79\u7d30\u80de\u300c\u518d\u751f\u91ab\u5b78\u300d\u958b\u555f\u4e86\u5c0d\u6297\u8001\u5316\u8207\u6cbb\u7642\u67d0\u4e9b\u7591\u96e3\u75be\u75c5\u7684\u65b0\u8996\u7a97\uff0c\u5e36\u4f86\u5d84\u65b0\u7684\u6cbb\u7642\u6a21\u5f0f\uff0c\u4e5f\u63a8\u52d5\u73fe\u4ee3\u81e8\u5e8a\u91ab\u5b78\u8de8\u5165\u524d\u6240\u672a\u6709\u7684\u9ad8\u5ea6\u30022011\u5e74\u5e79\u7d30\u80de\u518d\u751f\u91ab\u5b78\u61c9\u7528\u7372\u7f8e\u570b\u6642\u4ee3\u5468\u520a(TIME)\u8a55\u9078\u5e74\u5ea6\u5927\u767c\u660e\uff0c\u88ab\u55bb\u70ba\u662f\u4e0b\u4e00\u6ce2\u91ab\u5b78\u9769\u547d\uff01<\/p>\n
\u300c\u4e8c\u5341\u4e16\u7d00\u662f\u85e5\u7269\u6cbb\u7642\u7684\u4e16\u7d00\uff0c\u4e8c\u5341\u4e00\u4e16\u7d00\u662f\u7d30\u80de\u6cbb\u7642\u7684\u4e16\u7d00\u3002\u300d\u8fd1\u5e74\u4f86\u5168\u4e16\u754c\u7a4d\u6975\u6295\u5165\u5e79\u7d30\u80de\u7814\u767c\u9818\u57df\uff0c\u56e0\u70ba\u5e79\u7d30\u80de\u5177\u6709\u591a\u5411\u5206\u5316\u6f5b\u80fd\uff0c\u53ef\u4ee5\u7528\u4f86\u4fee\u5fa9\u56e0\u8001\u5316\u3001\u53d7\u50b7\u3001\u75be\u75c5\u6216\u6b63\u5e38\u6d41\u5931\u7684\u7279\u5b9a\u7d30\u80de\uff08\u5982\u6bcf\u9694\u5e7e\u5929\u66f4\u751f\u7684\u8178\u9053\u5167\u819c\uff09\u3002\u8eab\u9ad4\u7d30\u80de\u5728\u8001\u5316\u6216\u53d7\u640d\u6642\u6703\u6c38\u9060\u4e2d\u6b62\u7d30\u80de\u5206\u88c2\u529f\u80fd\uff08\u5df2\u4e0d\u80fd\u6b63\u5e38\u5206\u88c2\u3001\u66f4\u65b0\uff09\uff0c\u7559\u5728\u7d44\u7e54\u88e1\u65e2\u4e0d\u6b7b\u4ea1\uff0c\u4e5f\u7121\u6cd5\u6b63\u5e38\u767c\u63ee\u529f\u80fd\uff0c\u751a\u81f3\u6bd2\u5bb3\u9130\u8fd1\u7d30\u80de\uff0c\u5c0e\u81f4\u8eab\u9ad4\u6162\u6027\u5fae\u767c\u708e\u53ca\u5404\u7a2e\u6162\u6027\u75c5\uff0c\u5c31\u50cf\u55aa\u5c4d\u4e00\u6a23\uff0c\u9019\u4e9b\u56b4\u91cd\u53d7\u640d\u300c\u55aa\u5c4d\u7d30\u80de\u300d\uff08senescent cell\uff09\u96a8\u7740\u5e74\u9f61\u589e\u9577\u800c\u5927\u91cf\u7d2f\u7a4d\uff0c\u9032\u800c\u5c0e\u81f4\u764c\u75c7\u53ca\u8001\u5316\u3002<\/p>\n
\u4eba\u9ad4\u7d04\u7531200\u7a2e\u4e0d\u540c\u985e\u578b\u7684\u7d30\u80de\u7d44\u6210\uff0c\u6bcf\u985e\u7d30\u80de\u5c08\u8cac\u7279\u5b9a\u529f\u80fd\u3002\u76ee\u524d\u5229\u7528\u81ea\u9ad4\uff08autologous\uff09\u5e79\u7d30\u80de\u9054\u5230\u91ab\u7642\u61c9\u7528\u5df2\u65e5\u8da8\u6210\u719f\uff0c\u5f9e\u6700\u65e9\u7684\u540c\u7a2e\u7570\u9ad4\uff08allogeneic\uff09\u9aa8\u9ad3\u5e79\u7d30\u80de\u3001\u81cd\u5e36\u8840\u5e79\u7d30\u80de\u767c\u5c55\u81f3\u81ea\u9ad4\u9593\u8cea\u5e79\u7d30\u80de\u7684\u7814\u7a76\uff0c\u7d93\u904e\u9ad4\u5916\u57f9\u990a\u6216\u52a0\u5de5\u7a0b\u5e8f\u4e4b\u5f8c\uff0c\u518d\u5c07\u9019\u4e9b\u8655\u7406\u904e\u5177\u6709\u9ad8\u500d\u7684\u5206\u5316\u80fd\u529b\u5e79\u7d30\u80de\u5f15\u9032\u60a3\u8005\u9ad4\u5167\uff0c\u904e\u53bb\u675f\u624b\u7121\u7b56\u7684\u963f\u8332\u6d77\u9ed8\u75c7\u3001\u7cd6\u5c3f\u75c5\u3001\u5668\u5b98\u7d30\u80de\u8001\u5316\u554f\u984c\uff0c\u73fe\u5728\u6709\u6a5f\u6703\u7372\u5f97\u89e3\u6c7a\u3002<\/p>\n
\u80da\u80ce\u5e79\u7d30\u80de\u96d6\u7136\u597d\u7528\uff0c\u4f46\u53d6\u5f97\u904e\u7a0b\u6d89\u53ca\u300c\u6bba\u4eba\u300d\u7684\u722d\u8b70\uff0c\u57fa\u65bc\u9053\u5fb7\u7684\u8003\u91cf\uff0c\u76ee\u524d\u904b\u7528\u4e0a\u4ecd\u6709\u5f88\u5927\u9650\u5236\uff1b\u8fd1\u4f86\u91ab\u754c\u767c\u73fe\u53d6\u81ea\u6210\u5e74\u4eba\u7684\u6210\u9ad4\u9593\u8cea\u5e79\u7d30\u80de\uff0c\u5728\u9ad4\u5916\u53ef\u4ee5\u4eba\u5de5\u65b9\u6cd5\u8a98\u5c0e\u6210\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff08induced pluripotent stem cells\uff0ciPS\uff09\u5177\u5099\u81ea\u6211\u66f4\u65b0\u3001\u589e\u751f\u548c\u5206\u5316\u6210\u4e0d\u540c\u7d44\u7e54\u7d30\u80de\u7684\u529f\u80fd\u4ee5\u5916\uff0c\u9593\u8cea\u5e79\u7d30\u80de\u4e5f\u53ef\u4ee5\u81ea\u884c\u9a45\u52d5\u81f3\u7d44\u7e54\u53d7\u640d\u7684\u5730\u65b9\u9032\u884c\u4fee\u88dc\u3002\u6210\u9ad4\u9593\u8cea\u5e79\u7d30\u80de\u53ef\u7531\u9aa8\u9ad3\u3001\u81cd\u5e36\u3001\u80ce\u76e4\u3001\u8102\u80aa\u7b49\u4e0d\u540c\u7d44\u7e54\u4f86\u6e90\u53d6\u5f97\uff0c\u6bd4\u8d77\u5176\u4ed6\u53ef\u4ee5\u53d6\u5f97\u6210\u9ad4\u5e79\u7d30\u80de\u7684\u9014\u5f91\uff0c\u8102\u80aa\u7d44\u7e54\u5e7e\u4e4e\u7b49\u65bc\u662f\u53d6\u4e4b\u4e0d\u76e1\u3001\u7528\u4e4b\u4e0d\u7aed\uff0c\u904e\u7a0b\u7c21\u55ae\uff0c\u6c92\u6709\u6392\u65a5\u7684\u554f\u984c\uff0c\u4e00\u8209\u6578\u5f97\u3002\u56e0\u6b64\u8102\u80aa\u5e79\u7d30\u80de(adipose tissue stem cell; ADSC)\u88ab\u8a8d\u5b9a\u70ba\u662f\u6210\u9ad4\u5e79\u7d30\u80de\u6700\u4f73\u7684\u4f86\u6e90\uff0c\u5728\u7d30\u80de\u6cbb\u7642\u3001\u7d44\u7e54\u5de5\u7a0b\u8207\u518d\u751f\u91ab\u5b78\u4e0a\u7684\u61c9\u7528\uff0c\u5177\u6709\u76f8\u7576\u5927\u7684\u6f5b\u529b\u3002<\/p>\n
\u5e79\u7d30\u80de\u6cbb\u7642\u76ee\u524d\u7814\u7a76\u9818\u57df\u5305\u62ec\u8166\u4e2d\u98a8\u3001\u963f\u8332\u6d77\u9ed8\u75c7\u3001\u810a\u9ad3\u640d\u50b7\u3001\u809d\u786c\u5316\u3001\u5fc3\u81df\u8870\u7aed\u3001\u7cd6\u5c3f\u75c5\u3001\u8001\u5316\u7b49\u591a\u500b\u75be\u75c5\u9818\u57df\u3002\u885b\u798f\u90e8\u76ee\u524d\u7d30\u80de\u6cbb\u7642\u7e3d\u5171\u958b\u653e\u56db\u9805\u81ea\u9ad4\u7d30\u80de\u6cbb\u7642\u9805\u76ee\uff0c\u7686\u5c6c\u570b\u5916\u5df2\u65bd\u884c\u3001\u98a8\u96aa\u6027\u4f4e\uff0c\u6216\u5df2\u7d93\u65bc\u570b\u5167\u5be6\u65bd\u4eba\u9ad4\u8a66\u9a57\u7d2f\u7a4d\u9054\u4e00\u5b9a\u500b\u6848\u6578\uff0c\u5b89\u5168\u6027\u53ef\u78ba\u5b9a\u3001\u6210\u6548\u53ef\u9810\u671f\u4e4b\u300c\u81ea\u9ad4\u7d30\u80de\u300d\u7642\u6cd5\u4ee5\u5e6b\u52a9\u7d44\u7e54\u518d\u751f\u6216\u4fee\u5fa9\u70ba\u76ee\u6a19\uff0c\u5c0d\u75c5\u4eba\u4f86\u8aaa\u662f\u591a\u4e00\u500b\u6cbb\u7642\u7684\u9078\u64c7\u548c\u6a5f\u6703\u3002<\/p>\n
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