{"id":1871,"date":"2017-08-11T17:57:02","date_gmt":"2017-08-11T09:57:02","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/222010\/?p=1871"},"modified":"2017-08-11T17:57:02","modified_gmt":"2017-08-11T09:57:02","slug":"%e3%80%90%e9%81%8e%e6%95%8f%e5%85%8d%e7%96%ab%e9%a2%a8%e6%bf%95%e7%a7%91%e3%80%91%e5%83%b5%e7%9b%b4%e6%80%a7%e8%84%8a%e6%a4%8e%e7%82%8e%e6%9c%80%e6%96%b0%e8%97%a5%e7%89%a9%e7%99%bc%e5%b1%95%e8%b6%a8-2","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/222010\/?p=1871","title":{"rendered":"\u3010\u904e\u654f\u514d\u75ab\u98a8\u6fd5\u79d1\u3011\u50f5\u76f4\u6027\u810a\u690e\u708e\u6700\u65b0\u85e5\u7269\u767c\u5c55\u8da8\u52e2"},"content":{"rendered":"

<\/p>\n

\u6587\/\u904e\u654f\u514d\u75ab\u98a8\u6fd5\u79d1 \u9b4f\u6b63\u5b97 \u4e3b\u4efb\u3000<\/strong><\/p>\n

\u76ee\u524d\u5df2\u4e0a\u5e02\u6216\u5373\u5c07\u4e0a\u5e02\u7684\u65b0\u85e5\u6709\uff1a<\/p>\n

    \n
  1. \u975e\u985e\u56fa\u9187\u7684\u6d88\u708e\u6b62\u75db\u85e5\uff08<\/strong>NSAID<\/strong>\uff09\uff1a<\/strong>\u70ba\u6700\u57fa\u672c\u7684\u85e5\u7269\u6cbb\u7642\uff0c\u4e0d\u50c5\u80fd\u6e1b\u5c11\u767c\u708e\u53cd\u61c9\uff0c\u6e1b\u8f15\u75be\u75c5\u6240\u5e36\u4f86\u7684\u75bc\u75db\uff0c\u751a\u81f3\u6709\u7814\u7a76\u986f\u793a\u6bcf\u65e5\u898f\u5f8b\u670d\u7528\u6b64\u985e\u85e5\u7269\u53ef\u6e1b\u5c11\u810a\u690e\u7684\u9223\u5316\u53ca\u9ecf\u5408\u3002<\/li>\n
  2. \u514d\u75ab\u8abf\u7bc0\u5291<\/strong>(DMARD) :<\/strong>\u53e6\u5916\u9031\u908a\u578b\u60a3\u8005\u53ef\u642d\u914d\u514d\u75ab\u8abf\u7bc0\u5291<\/strong>(sulfasalazine)<\/strong>\u7684\u4f7f\u7528\uff0c\u4ee5\u8abf\u7bc0\u514d\u75ab\u529f\u80fd\u3002\u514d\u75ab\u8abf\u7bc0\u5291\u53ef\u4ee5\u6539\u5584\u50f5\u76f4\u6027\u810a\u690e\u708e\u7684\u9031\u908a\u95dc\u7bc0\u708e\uff0c\u4f46\u5c0d\u4e2d\u8ef8\u95dc\u7bc0\u7684\u75c7\u72c0\u4e26\u6c92\u6709\u592a\u5927\u7684\u6539\u5584\u3002<\/li>\n
  3. \u6297\u816b\u7624\u58de\u6b7b\u56e0\u5b50\u751f\u7269\u88fd\u5291\uff08<\/strong>TNF-\u03b1<\/strong>\u6291\u5236\u5291\uff09\uff1a<\/strong>\u70ba\u76ee\u524d\u6cbb\u7642\u50f5\u76f4\u6027\u810a\u690e\u708e\u7684\u4e3b\u6d41\uff0c\u6b64\u985e\u85e5\u7269\u662f\u4ee5\u57fa\u56e0\u5de5\u7a0b\u65b9\u5f0f\u88fd\u9020\u51fa\u878d\u5408\u86cb\u767d\u6216\u55ae\u682a\u6297\u9ad4\uff0c\u7cbe\u6e96\u7684\u7784\u6e96\u9019\u4e9b\u7570\u5e38\u7684\u514d\u75ab\u5206\u5b50\uff0c\u4ee5\u6291\u5236\u767c\u708e\u53cd\u61c9\uff0c\u8fd1\u5e7e\u5e74\u570b\u5167\u91dd\u5c0d\u50f5\u76f4\u6027\u810a\u690e\u708e\u5df2\u9678\u7e8c\u4e0a\u5e02\u4e86\u591a\u7a2e\u6b64\u985e\u85e5\u7269\uff0c\u5305\u62ecEtanercept\uff08Enbrel,\u6069\u535a\uff09\u3001Adalimumab\uff08Humira,\u5fa9\u9081\uff09\u3001Golimumab\uff08Simponi,\u8f9b\u666e\u5c3c\uff09\uff0c\u6b64\u985e\u85e5\u7269\u56e0\u5206\u5b50\u91cf\u5927\uff0c\u9808\u4ee5\u76ae\u4e0b\u6ce8\u5c04\u65b9\u5f0f\u6cbb\u7642\u3002<\/li>\n
  4. IL-23<\/strong>\u6291\u5236\u5291\uff1a<\/strong>Ustekinumab (Stelara,\u559c\u9054\u8afe)<\/strong>\u7531\u694a\u68ee\u85e5\u5ee0\u7814\u767c\uff0c\u5df2\u901a\u904e\u53f0\u7063\u5065\u4fdd\uff0c\u7528\u65bc\u4e7e\u766c\u53ca\u4e7e\u766c\u95dc\u7bc0\u708e\u75c5\u4eba\uff0c\u7642\u6548\u6975\u4f73\uff0c\u70ba\u76ee\u524d\u6cbb\u7642\u4e7e\u766c\u6700\u6709\u6548\u7684\u85e5\u7269\u3002\u53e6\u5916\u767e\u9f61\u4f73\u85e5\u5ee0\u7684IL-23\u6291\u5236\u5291<\/strong>\u5728\u521d\u6b65\u7684\u7814\u7a76\u986f\u793a\u5c0d\u4e7e\u766c\u75c5\u4eba\u4e5f\u6709\u5f88\u597d\u7684\u7642\u6548\uff0c\u6cbb\u7642\u4e09\u500b\u6708\u5e73\u5747\u53ef\u4ee5\u964d\u4f4e\u76ae\u819a\u4e7e\u766c\u7684\u56b4\u91cd\u6307\u6a19\uff08PASI\uff09\u905475%\u3002<\/li>\n
  5. IL-17<\/strong>\u6291\u5236\u5291\uff1a<\/strong>\u8afe\u83ef\u85e5\u5ee0\u7684Secukinumab (Cosentyx,\u53ef\u5584\u633a)\u5df2\u65bc2015\u5e74\u5e95\u5728\u53f0\u7063\u4e0a\u5e02\uff0c\u5728\u6b50\u6d32\u53ca\u7f8e\u570b\u90fd\u5df2\u6838\u51c6\u7528\u65bc\u50f5\u76f4\u6027\u810a\u690e\u708e\uff0c\u4e7e\u766c\u53ca\u4e7e\u766c\u95dc\u7bc0\u708e\u3002\u76ee\u524d\u4e2d\u5c71\u91ab\u5b78\u5927\u5b78\u6b63\u53c3\u8207\u6b64\u85e5\u7684\u5168\u7403\u81e8\u5e8a\u8a66\u9a57\uff0c\u6b64\u85e5\u5c0d\u50f5\u76f4\u6027\u810a\u690e\u708e\u6548\u679c\u4e0d\u932f\uff0c\u5b89\u5168\u6027\u66f4\u597d\u3002\u672a\u4f86IL-17\u53caIL-23\u76f8\u95dc\u751f\u7269\u5236\u5291\u53ef\u8aaa\u662f\u6cbb\u7642\u50f5\u76f4\u6027\u810a\u690e\u708e\u3001\u4e7e\u766c\u53ca\u4e7e\u766c\u95dc\u7bc0\u708e\u7684\u6700\u71b1\u9580\u4e4b\u85e5\u7269\u3002<\/li>\n
  6. \u53e3\u670d\u578b\u5c0f\u5206\u5b50\u6a19\u9776\u85e5\u7269\uff1a<\/strong>\u76f8\u5c0d\u65bc\u76ae\u4e0b\u6ce8\u5c04\u578b\u7684TNF-\u03b1\uff0c\u53e3\u670d\u578b\u5c0f\u5206\u5b50\u6a19\u9776\u85e5\u7269<\/strong>\u662f\u672a\u4f86\u5099\u53d7\u77da\u76ee\u7684\u65b0\u85e5\u8da8\u52e2\uff0c\u76ee\u524d\u7531\u8f1d\u745e\u85e5\u5ee0\u6240\u7814\u767c\u7684Tofacitinib\u5df2\u7d93\u901a\u904e\u7f8e\u570bFDA\u5be9\u6838\u4e26\u53ef\u4f7f\u7528\u65bc\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\uff0c\u6b64\u85e5\u7269\u4f5c\u7528\u6a5f\u5236\u662f\u85c9\u7531\u963b\u65b7\u4eba\u9ad4\u5167\u6fc0\u6d3b\u514d\u75ab\u548c\u767c\u708e\u53cd\u61c9\u7684\u8a0a\u865fJAK\u901a\u904e\uff0c\u9032\u800c\u6e1b\u5c11\u76f8\u95dc\u7684\u767c\u708e\u7d30\u80de\u6fc0\u7d20\u7684\u7522\u751f\uff0c\u800c\u9054\u5230\u6cbb\u7642\u95dc\u7bc0\u708e\u7684\u76ee\u7684\u3002\u76ee\u524d\u6709\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\u91dd\u5c0d\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\u60a3\u8005\u6709\u660e\u986f\u7684\u7642\u6548\uff0c\u76f8\u8f03\u65bc\u50b3\u7d71\u53e3\u670d\u85e5\uff0cTofacitinib\u66f4\u80fd\u6e1b\u8f15\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\u7684\u75c7\u72c0\u53ca\u8868\u5fb5\u3001\u9810\u9632\u95dc\u7bc0\u7684\u7d50\u69cb\u6027\u640d\u5bb3\u548c\u6539\u5584\u60a3\u8005\u7684\u751f\u7406\u529f\u80fd\u3002\u526f\u4f5c\u7528\u4ee5\u611f\u67d3\u8f03\u5e38\u898b\uff0c\u4f46\u6a5f\u7387\u4e0d\u9ad8\uff0c\u4ecd\u5c6c\u53ef\u9810\u9632\u53ca\u8655\u7406\u3002\u56e0\u6b64\u570b\u5167\u6b63\u7a4d\u6975\u9032\u884c\u6b64\u85e5\u7269\u5c0d\u65bc\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\u3001\u50f5\u76f4\u6027\u810a\u690e\u708e\u53ca\u4e7e\u766c\u6027\u95dc\u7bc0\u708e\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u671f\u5f85\u672a\u4f86\u67d0\u4e00\u5929\u6b64\u85e5\u7269\u4e5f\u80fd\u5728\u570b\u5167\u88ab\u5ee3\u6cdb\u4f7f\u7528\uff0c\u8b93\u66f4\u591a\u7684\u98a8\u6fd5\u514d\u75ab\u60a3\u8005\u53d7\u76ca\u3002<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":["post-1871","post","type-post","status-publish","format-standard","hentry","category-doc-heaedu"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=\/wp\/v2\/posts\/1871"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1871"}],"version-history":[{"count":1,"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=\/wp\/v2\/posts\/1871\/revisions"}],"predecessor-version":[{"id":1872,"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=\/wp\/v2\/posts\/1871\/revisions\/1872"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1871"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1871"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1871"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}