{"id":1227,"date":"2017-03-14T09:52:23","date_gmt":"2017-03-14T01:52:23","guid":{"rendered":"http:\/\/web.csh.org.tw\/web\/222010\/?p=1227"},"modified":"2017-05-04T14:36:11","modified_gmt":"2017-05-04T06:36:11","slug":"%e9%a1%9e%e9%a2%a8%e6%bf%95%e9%97%9c%e7%af%80%e7%82%8e%e4%b9%8b%e7%94%9f%e7%89%a9%e8%a3%bd%e5%8a%91%e5%85%8d%e7%96%ab%e6%a8%99%e9%9d%b6%e8%97%a5%e7%89%a9","status":"publish","type":"post","link":"https:\/\/web.csh.org.tw\/web\/222010\/?p=1227","title":{"rendered":"\u3010\u904e\u654f\u514d\u75ab\u98a8\u6fd5\u79d1\u3011\u985e\u98a8\u6fd5\u95dc\u7bc0\u708e\u4e4b\u751f\u7269\u88fd\u5291\u514d\u75ab\u6a19\u9776\u85e5\u7269"},"content":{"rendered":"

\u6587\/\u904e\u654f\u514d\u75ab\u98a8\u6fd5\u79d1 \u9b4f\u6b63\u5b97\u4e3b\u4efb<\/h4>\n

\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e(Rheumatoid Arthritis\uff0c\u7c21\u7a31RA)\u70ba\u81ea\u9ad4\u514d\u75ab\u9020\u6210\u7684\u591a\u767c\u6027\u53ca\u6162\u6027\u95dc\u7bc0\u708e\uff1b\u5178\u578b\u75c7\u72c0\u70ba\u5168\u8eab\u591a\u8655\u5c0f\u95dc\u7bc0\u816b\u75db\u6216\u6668\u9593\u50f5\u786c\uff0c\u82e5\u4e0d\u6cbb\u7642\uff0c\u53ef\u80fd\u9020\u6210\u95dc\u7bc0\u7684\u7834\u58de\u53ca\u8b8a\u5f62\u3002
\n
\n\u76ee\u524d\u53f0\u7063\u4e14\u5065\u4fdd\u7d66\u4ed8\u5df2\u4e0a\u5e02\u751f\u7269\u88fd\u5291<\/span><\/p>\n

1.\u6297\u816b\u7624\u58de\u6b7b\u56e0\u5b50\u751f\u7269\u88fd\u5291\uff1a\u76ee\u524d\u5065\u4fdd\u7d66\u4ed8\u65bc\u56b4\u91cd\u9811\u56fa\u578b\u4e4b\u985e\u98a8\u6ebc\u6027\u95dc\u7bc0\u708e\u3001\u50f5\u76f4\u6027\u810a\u690e\u708e\u3001\u4e7e\u766c\u3001\u4e7e\u766c\u95dc\u7bc0\u708e\uff0c\u9700\u5148\u5831\u5065\u4fdd\u5c40\u5be9\u67e5\u3002<\/p>\n

I. Etanercept\uff08\u5546\u54c1\u540dEnbrel\u6069\u535a\uff09\u7531\u4e2d\u570b\u5009\u9f20\u5375\u5de2\u7d30\u80de\u7d44\u7e54\u57f9\u990a\u800c\u4f86\u5c0d\u6297\u816b\u7624\u58de\u6b7b\u56e0\u5b50\u7684\u878d\u5408\u86cb\u767d\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u5468\u5169\u6b21\u3002<\/p>\n

II.\u00a0Adalimumab\uff08\u5546\u54c1\u540dHumira\u5fa9\u9081\uff09\u4e00\u7a2e\u5168\u4eba\u7684\u816b\u7624\u58de\u6b7b\u56e0\u5b50\u7684\u55ae\u682a\u6297\u9ad4\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u5169\u5468\u4e00\u6b21\u3002<\/p>\n

III. Golimumab\uff08\u5546\u54c1\u540dSimponi\u8f9b\u666e\u5c3c\uff09\u4e00\u7a2e\u5168\u4eba\u7684\u816b\u7624\u58de\u6b7b\u56e0\u5b50\u7684\u55ae\u682a\u6297\u9ad4\uff0c\u6bcf\u56db\u5468\u76ae\u4e0b\u6ce8\u5c04\u4e00\u6b21\u5373\u53ef\uff0c\u4f7f\u7528\u8f03\u65b9\u4fbf\u3002<\/p>\n

2.\u00a0Rituxtimab\uff08\u5546\u54c1\u540dMabTheRa\u83ab\u9808\u7624\uff09\uff1a\u80fd\u8207B\u6dcb\u5df4\u7d30\u80de\u4e0aCD20\u6297\u539f\u7d50\u5408\uff0c\u7528\u4f86\u6cbb\u7642\u9aa8\u9ad3\u7624\u53ca\u985e\u98a8\u6ebc\u6027\u95dc\u7bc0\u708e\uff0c\u4e5f\u6709\u5831\u544a\u5c0d\u7d05\u6591\u72fc\u7621\u53ca\u4e7e\u71e5\u75c7\u6709\u6548\u3002\u53f0\u7063\u5065\u4fdd\u5373\u5c07\u7d66\u4ed8\u5c0d\u6297\u816b\u7624\u58de\u6b7b\u56e0\u5b50\u88fd\u5291\u7121\u6548\u7684\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\u3002\u6bcf\u5e74\u82b1\u8cbb\u7d0416-32\u842c\u3002\u975c\u8108\u8f38\u6ce8\uff0c\u5291\u91cf\u6bcf\u6b21500-1000mg\uff0c\u9593\u969414\u5929\u518d\u8f38\u6ce8\uff0c\u51712\u6b21\u3002<\/p>\n

3.\u00a0Abatacept\uff08\u5546\u54c1\u540dOrencia \u6069\u745e\u8212\uff09\u900f\u904eT\u7d30\u80de\u6d3b\u5316\u7684\u6291\u5236\u56e0\u5b50CTLA4\uff0c\u800c\u9054\u5230\u8abf\u7bc0\u514d\u75ab\u76ee\u7684\uff0c\u9069\u61c9\u75c7\u70ba\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\uff0c\u975c\u8108\u8f38\u6ce8\uff0c\u6bcf\u6708\u4e00\u6b21\u3002<\/p>\n

4.\u00a0Tocilizumab\uff08\u5546\u54c1\u540dActemra\u5b89\u633a\u6a02\uff09\u4e00\u7a2eIL-6\u55ae\u682a\u6297\u9ad4\uff0c\u53ef\u5e6b\u52a9\u75c7\u72c0\u9032\u6b65\u53ca\u6e1b\u5c11\u95dc\u7bc0\u7834\u58de\uff0c\u4e5f\u80fd\u6539\u5584\u8ca7\u8840\u53ca\u75b2\u5026\u75c7\u72c0\u3002\u975c\u8108\u8f38\u6ce8\uff0c\u6bcf\u6708\u4e00\u6b21\u3002<\/p>\n

\u5c0f\u5206\u5b50\u53e3\u670d\u6a19\u9776\u85e5\u7269<\/p>\n

\u7531\u8f1d\u745e(Pfizer)\u85e5\u5ee0\u7814\u767c\u7684\u300e\u5c0f\u5206\u5b50\u53e3\u670d\u6a19\u9776\u85e5\u7269\u300fTofacitinib\uff08\u5546\u54c1\u540dXeljanz\u6377\u6291\u708e\uff09\uff0c\u6a5f\u8f49\u662f\u6291\u5236\u7d30\u80de\u5167\u8a0a\u606f\u50b3\u905e\u5206\u5b50JAK-3\uff0c\u6548\u679c\u4e0d\u4e9e\u65bc\u751f\u7269\u88fd\u5291\uff0c\u5df2\u5728\u7f8e\u570b\u53ca\u53f0\u7063\u4e0a\u5e02\uff0c\u7528\u65bc\u50b3\u7d71\u514d\u75ab\u8abf\u7bc0\u5291\u7121\u6548\u4e4b\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\u3002<\/p>\n

\u53f0\u7063\u672a\u4e0a\u5e02\u4f46\u5df2\u9032\u884c\u81e8\u5e8a\u8a66\u9a57\u7684\u65b0\u85e5<\/span><\/p>\n

1. \u00a0Baricitinib\/Peficitinib\/ABT-494\uff1a\u300e\u5c0f\u5206\u5b50\u53e3\u670d\u6a19\u9776\u85e5\u7269\u300f\uff0c\u6a5f\u8f49\u662f\u6291\u5236\u7d30\u80de\u5167\u8a0a\u606f\u50b3\u905e\u5206\u5b50JAK-3\uff0c\u76ee\u524d\u5c1a\u672a\u4e0a\u5e02\uff0c\u9032\u884c\u8de8\u570b\u81e8\u5e8a\u8a66\u9a57\u4e2d\u3002<\/p>\n

2. \u751f\u7269\u76f8\u4f3c\u6027\u85e5\u54c1Biosimilars\uff1a\u4ee5\u751f\u7269\u6280\u8853\u884d\u751f\u4e4b\u751f\u7269\u85e5\u54c1\uff0c\u65bc\u54c1\u8cea\u3001\u5b89\u5168\u53ca\u7642\u6548\u4e0a\u8207\u539f\u672c\u53c3\u8003\u85e5\u54c1\u4e14\u7372\u5f97\u4e0a\u5e02\u8a31\u53ef\u4e4b\u539f\u958b\u767c\u751f\u7269\u85e5\u54c1\u76f8\u4f3c\u8005\u3002\u76ee\u524d\u8a31\u591a\u570b\u5916\u5927\u85e5\u5ee0\u53ca\u570b\u5167\u6771\u751f\u83ef\u85e5\u5ee0\u7686\u6709\u7522\u54c1\u9032\u884c\u81e8\u5e8a\u8a66\u9a57\u4e2d\u3002<\/p>\n

\u7d50\u8ad6<\/span><\/p>\n

\u6a19\u9776\u85e5\u7269\u7684\u597d\u8655\u662f\u7642\u6548\u5927\u65bc\u50b3\u7d71\u85e5\u7269\uff0c\u767c\u751f\u526f\u4f5c\u7528\u7684\u6a5f\u6703\u4e5f\u4f4e\uff0c\u4f46\u50f9\u683c\u6602\u8cb4\uff0c\u5e73\u5747\u6bcf\u4eba\u6bcf\u5e74\u7684\u82b1\u8cbb\u7d0440\u842c\uff0c\u53ea\u6709\u5c11\u6578\u56b4\u91cd\u578b\u75c5\u4eba\u5f97\u4ee5\u901a\u904e\u5065\u4fdd\u7d66\u4ed8\u3002<\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u6587\/\u904e\u654f\u514d\u75ab\u98a8\u6fd5\u79d1 \u9b4f\u6b63\u5b97\u4e3b\u4efb \u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e(Rheumatoid Arthritis\uff0c\u7c21\u7a31RA)… <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":["post-1227","post","type-post","status-publish","format-standard","hentry","category-doc-heaedu"],"_links":{"self":[{"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=\/wp\/v2\/posts\/1227"}],"collection":[{"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1227"}],"version-history":[{"count":9,"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=\/wp\/v2\/posts\/1227\/revisions"}],"predecessor-version":[{"id":1691,"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=\/wp\/v2\/posts\/1227\/revisions\/1691"}],"wp:attachment":[{"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1227"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1227"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.csh.org.tw\/web\/222010\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1227"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}